YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|30264969, gi\|...
Organism:	Bacillus anthracis str. Ames
Length:	331 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|30264969, gi|....

Description	E-value	Query Range	Subject Range
gi\|18893541, gi\|... - gi\|18977794\|ref\|NP_579151.1\| thioredoxin reductase [Pyrococcus furiosus DSM 3638], gi\|18893541\|gb\|AA...	7.0E-63	[2..318]	[36..349]
gi\|57642035, gi\|... - gi\|57642035\|ref\|YP_184513.1\| thioredoxin reductase [Thermococcus kodakarensis KOD1], gi\|57160359\|dbj...	7.0E-62	[6..318]	[14..323]
gi\|7431886, gi\|5... - pir\|\|D75116 thioredoxin reductase (trxb) PAB0500 - Pyrococcus abyssi (strain Orsay), gi\|5458156\|emb... gi\|14520939, gi\|... - gi\|5458156\|emb\|CAB49645.1\| trxB thioredoxin reductase [Pyrococcus abyssi GE5], gi\|14520939\|ref\|NP_12...	3.0E-61	[4..317]	[27..337]
gi\|3257849, gi\|1... - gi\|3257849\|dbj\|BAA30532.1\| 336aa long hypothetical thioredoxin reductase [Pyrococcus horikoshii OT3]... gi\|7431883 - pir\|\|D71016 probable thioredoxin reductase - Pyrococcus horikoshii	3.0E-60	[2..317]	[16..328]
FENR2_LISIN - Ferredoxin--NADP reductase 2 OS=Listeria innocua GN=lin2489 PE=3 SV=1 FENR2_LISIN - Ferredoxin--NADP reductase 2 OS=Listeria innocua serovar 6a (strain CLIP 11262) GN=lin2489 PE=3 SV=1	8.0E-60	[3..331]	[1..330]
FENR2_BACSK - Ferredoxin--NADP reductase 2 OS=Bacillus clausii (strain KSM-K16) GN=ABC2925 PE=3 SV=1	8.0E-60	[3..331]	[1..330]
gi\|22295650, gi\|... - gi\|22299467\|ref\|NP_682714.1\| thioredoxin reductase [Thermosynechococcus elongatus BP-1], gi\|22295650...	1.0E-59	[4..326]	[1..322]
gi\|126941011, gi... - gi\|254901148\|ref\|ZP_05261072.1\| hypothetical protein LmonJ_15092 [Listeria monocytogenes J0161], gi\|... gi\|127632036, gi... - gi\|254831186\|ref\|ZP_05235841.1\| hypothetical protein Lmon1_07488 [Listeria monocytogenes 10403S], gi... gi\|254914065, gi... - gi\|254914065\|ref\|ZP_05264077.1\| hypothetical protein LmonJ2_14777 [Listeria monocytogenes J2818], gi... gi\|255028819 - gi\|255028819\|ref\|ZP_05300770.1\| hypothetical protein LmonL_05856 [Listeria monocytogenes LO28] gi\|255026484 - gi\|255026484\|ref\|ZP_05298470.1\| hypothetical protein LmonocytFSL_09373 [Listeria monocytogenes FSL J... gi\|47015746, gi\|... - gi\|47095869\|ref\|ZP_00233473.1\| pyridine nucleotide-disulfide oxidoreductase family protein [Listeria... gi\|254938380 - gi\|254938380\|ref\|ZP_05270077.1\| hypothetical protein LmonF6_14705 [Listeria monocytogenes F6900] FENR2_LISMO - Ferredoxin--NADP reductase 2 OS=Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) GN... FENR2_LISMO - Ferredoxin--NADP reductase 2 OS=Listeria monocytogenes GN=lmo2390 PE=3 SV=1 gi\|224500590 - gi\|224500590\|ref\|ZP_03668939.1\| hypothetical protein LmonF1_13326 [Listeria monocytogenes Finland 19... gi\|224503721 - gi\|224503721\|ref\|ZP_03672028.1\| hypothetical protein LmonFR_14679 [Listeria monocytogenes FSL R2-561...	2.0E-59	[3..331]	[1..330]
gi\|254992246 - gi\|254992246\|ref\|ZP_05274436.1\| thioredoxine reductase [Listeria monocytogenes FSL J2-064] gi\|47018629, gi\|... - gi\|47092975\|ref\|ZP_00230755.1\| pyridine nucleotide-disulfide oxidoreductase family protein [Listeria... gi\|217332774, gi... - gi\|217963504\|ref\|YP_002349182.1\| pyridine nucleotide-disulfide oxidoreductase family protein [Lister... gi\|254873687, gi... - gi\|254873687\|ref\|ZP_05246397.1\| thioredoxine reductase [Listeria monocytogenes FSL N1-017], gi\|15316... gi\|254826348 - gi\|254826348\|ref\|ZP_05231349.1\| thioredoxine reductase [Listeria monocytogenes FSL J1-194] gi\|225877405, gi... - gi\|226224943\|ref\|YP_002759050.1\| thioredoxine reductase [Listeria monocytogenes Clip81459], gi\|22587... gi\|254880405 - gi\|254880405\|ref\|ZP_05253115.1\| thioredoxine reductase [Listeria monocytogenes FSL J2-071] gi\|254933662, gi... - gi\|254933662\|ref\|ZP_05267021.1\| thioredoxine reductase [Listeria monocytogenes HPB2262], gi\|15320396... gi\|254854458 - gi\|254854458\|ref\|ZP_05243806.1\| thioredoxine reductase [Listeria monocytogenes FSL R2-503]	2.0E-59	[3..331]	[1..330]
FENR2_BACLD - Ferredoxin--NADP reductase 2 OS=Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC...	2.0E-59	[3..331]	[1..329]

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Predicted Domain #1

Region A:
Residues: [1-331]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKVAENQKVY DITIIGGGPT GLFTAFYGGM RQASVKIIES LPQLGGQLSA LYPEKYIYDV  60
   61 AGFPKVRAQE LVDNLKEQMK KFDPTVCLEE AVDTLEKQAD GIFKLVTNKQ THYSKSVIIT 120
  121 AGNGAFQPRR LELEGTAKYE KKNLHYFVDD MNKFAGKRVV VFGGGDSAVD WTMMLEPIAD 180
  181 KVTIVHRRDK FRAHEHSVES LMNSRAEVST PYVPVELIGD DKIEQVVLQH VKTEEKIIID 240
  241 VDDVIVNYGF VSSLGPIKNW GLDIQKNSIL VNSKMETNIP GIYAAGDICT YEGKVKLIAC 300
  301 GFGEAPTAVN NAKAYFDPNA KLQPMHSSSM F

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	57.522879
Match:	1tdeA
Description:	CRYSTAL STRUCTURE OF ESCHERICHIA COLI THIOREDOXIN REDUCTASE REFINED AT 2 ANGSTROM RESOLUTION: IMPLICATIONS FOR A LARGE CONFORMATIONAL CHANGE DURING CATALYSIS
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
thioredoxin-disulfide reductase activity	3.42654162439464	bayes_pls_golite062009
antioxidant activity	3.37477730756688	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	3.17769237742078	bayes_pls_golite062009
catalytic activity	1.56773888754354	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor	1.45104542724719	bayes_pls_golite062009
binding	1.4227698123368	bayes_pls_golite062009
oxidoreductase activity	0.44090433301056	bayes_pls_golite062009
oxygen-dependent protoporphyrinogen oxidase activity	0.1498172520052	bayes_pls_golite062009
dihydrolipoyl dehydrogenase activity	0.130601418359425	bayes_pls_golite062009
protein binding	0.116927178396589	bayes_pls_golite062009
disulfide oxidoreductase activity	0.0160065137614933	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: