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View Structure Prediction Details

Protein: unc-44
Organism: Caenorhabditis elegans
Length: 795 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for unc-44.

Description E-value Query
Range
Subject
Range
gi|31873714 - gi|31873714|emb|CAD97827.1| hypothetical protein [Homo sapiens]
894.0 [0..1] [795..972]

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Predicted Domain #1
Region A:
Residues: [1-87]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRGCRHSGVR IIVPPRKASQ PIRVTCRYLR KDKLAHPPPL SEGEELASRI LEMAPAGAKF  60
   61 LGPVILEVPH FASLRDRERE IVILRSD

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 48.49485
Match: PF00791.11
Description: No description for PF00791.11 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [88-190]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DGQHWKEHQL EATEDAVQEV LNESFDAEDL AQLDDLQTPR ITRILTSDFP MYFAVVTRVR  60
   61 QEVHCVGPEG GVIISSVVPR VQAIFPDGSL TKTIKVSVQA QPV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [191-400]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PQEMVTRLHG NRVAVSPIVT VEPRRRKFHK PITLCIPLPQ SNNRGMLTQY SGQQGQEPPT  60
   61 LRLLCSITGG SAPAQWEDIT GTTQLTFTGD EVSFTTTVSA RFWLMDCQTP RDAARMAQEV 120
  121 YNEAISIPYM AKFAVFARRT FPVEGQLRVF CMTDDKEDKT LEKQEHFKLI AKSRDVEVLK 180
  181 GKHQFLEFSG NLVPITKSGD QLSLFFLPFQ 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [401-467]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ENRLAFMVKT RSNDDNEAAT EGRIGFMAEP KIRSDALPPQ QPICTLAISL PEYTGEIKTA  60
   61 PPPKKDL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [468-591]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TPFEQRYGSA LEKDLPEFVH QNVLKGIGAD WPRLGRALEV PHRDIQHIRQ NYPGQECKNT  60
   61 LKIWIHLKKE DANQDNLDQA LRQIGRDDIV RSIAYGEPDA LINYSQADSP SQKREPIRHF 120
  121 EEVP

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.22
Match: 1ddfA
Description: FAS DEATH DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.68614941294654 bayes_pls_golite062009
protein binding 2.15754892228292 bayes_pls_golite062009
transmembrane receptor activity 1.41916116236037 bayes_pls_golite062009
receptor activity 1.39541116892971 bayes_pls_golite062009
signal transducer activity 1.16091953151708 bayes_pls_golite062009
molecular transducer activity 1.16091953151708 bayes_pls_golite062009
protein domain specific binding 0.398139770818158 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [592-795]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AATLVKREVR TEDLVTREPV QPTHHVEQAT TVVQEPSYSA PVHHSPVPEE PEMEEEAPVA  60
   61 EMRTVVRTER HVHDSEDGPV VEERTITTTY EDDVAVNENI VDRTVPLNED EQQKWEELNR 120
  121 LADESSPSPA QRSTIVAEST SEQVPEDVEQ SVESESHRED DGTIVTTTVT TSHISESPSG 180
  181 SPTRRSVEPE EHRHSQHEDH EGST

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle