YRC Public Data Repository - Protein Structure Prediction

Protein:	RLMB_COXBU
Organism:	Coxiella burnetii RSA 493
Length:	250 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RLMB_COXBU.

Description	E-value	Query Range	Subject Range
gi\|164601225, gi... - gi\|164685717\|ref\|ZP_01945643.2\| RNA methyltransferase, TrmH family, group 3 [Coxiella burnetii 'MSU ... gi\|165918586, gi... - gi\|165918586\|ref\|ZP_02218672.1\| RNA methyltransferase, TrmH family, group 3 [Coxiella burnetii RSA 3... gi\|212218447, gi... - gi\|212218447\|ref\|YP_002305234.1\| 23S rRNA Gm2251 methyltransferase [Coxiella burnetii CbuK_Q154], gi... gi\|154355379, gi... - gi\|94492068\|ref\|ZP_01299277.1\| hypothetical protein CburD_01000958 [Coxiella burnetii Dugway 7E9-12]...	264.0	[0..1]	[250..21]
gi\|95927296, gi\|... - gi\|95927296\|ref\|ZP_01310056.1\| hypothetical protein CburR_01000902 [Coxiella burnetii RSA 331], gi\|1...	263.0	[0..1]	[250..21]
gi\|25316695 - pir\|\|A83664 tRNA/rRNA methyltransferase BH0113 [imported] - Bacillus halodurans (strain C-125) gi\|15612676, gi\|... - gi\|15612676\|ref\|NP_240979.1\| tRNA/rRNA methyltransferase [Bacillus halodurans C-125], gi\|10172725\|db...	262.0	[0..1]	[245..1]
gi\|77954715, gi\|... - gi\|77954715\|ref\|ZP_00819103.1\| RNA methyltransferase TrmH, group 3 [Marinobacter aquaeolei VT8], gi\|...	261.0	[0..1]	[244..1]
gi\|23104564 - ref\|ZP_00091028.1\| COG0566: rRNA methylases [Azotobacter vinelandii] gi\|226942911, gi... - gi\|67157138\|ref\|ZP_00418500.1\| RNA methyltransferase TrmH, group 3 [Azotobacter vinelandii AvOP], gi...	259.0	[0..1]	[247..1]
gi\|148549961, gi... - gi\|82740155\|ref\|ZP_00902910.1\| RNA methyltransferase TrmH, group 3 [Pseudomonas putida F1], gi\|82712...	259.0	[0..1]	[248..1]
RLMB_PSEPK - 23S rRNA (guanosine-2'-O-)-methyltransferase RlmB OS=Pseudomonas putida (strain KT2440) GN=rlmB PE=3...	257.0	[0..1]	[245..1]
gi\|70734080, gi\|... - gi\|70734080\|ref\|YP_257720.1\| RNA methyltransferase [Pseudomonas fluorescens Pf-5], gi\|68348379\|gb\|AA...	257.0	[0..1]	[245..1]
RLMB_PSESM - 23S rRNA (guanosine-2'-O-)-methyltransferase RlmB OS=Pseudomonas syringae pv. tomato (strain DC3000)... RLMB_PSESM - 23S rRNA (guanosine-2'-O-)-methyltransferase rlmB OS=Pseudomonas syringae pv. tomato GN=rlmB PE=3 SV...	257.0	[0..1]	[249..1]
gi\|218894031, gi... - gi\|218894031\|ref\|YP_002442900.1\| putative rRNA methylase [Pseudomonas aeruginosa LESB58], gi\|2187742... RLMB_PSEAE - 23S rRNA (guanosine-2'-O-)-methyltransferase rlmB OS=Pseudomonas aeruginosa GN=rlmB PE=3 SV=1 RLMB_PSEAE - 23S rRNA (guanosine-2'-O-)-methyltransferase RlmB OS=Pseudomonas aeruginosa (strain ATCC 15692 / PAO... gi\|254244173, gi... - gi\|84323721\|ref\|ZP_00971789.1\| COG0566: rRNA methylases [Pseudomonas aeruginosa 2192], gi\|254244173\|...	257.0	[0..1]	[244..1]

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Predicted Domain #1

Region A:
Residues: [1-250]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKIKSIYGI HAVSGVLDAA PQRIVKLYVQ ENRDDQRLQS LVEKAKALGV KVILLSRTEL  60
   61 NTLSNEKHQG IVADCEEVEN LDESALLSLL KKRETPALLL ILDGVKDPHN LGACLRSANA 120
  121 FGVRAVIAPK DRAVGVTPVV RKVACGAAEM TPFIRVTNLS RTIDWLQKEG VWIVGTAVEA 180
  181 ETLIQEIDLT GDIAIVLGSE GAGLRRLTKE RCDFLAQIPL RGSVESLNVS VACGICLYEV 240
  241 QRQREAPAPS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	65.30103
Match:	1gz0A
Description:	RlmB, C-terminal domain; RlmB, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
RNA methyltransferase activity	4.23455016472464	bayes_pls_golite062009
methyltransferase activity	3.59960278169345	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	3.51722801996622	bayes_pls_golite062009
rRNA methyltransferase activity	3.14976989427746	bayes_pls_golite062009
tRNA methyltransferase activity	2.33123191403389	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	2.23755555119187	bayes_pls_golite062009
tRNA (guanine) methyltransferase activity	2.14623472760939	bayes_pls_golite062009
transferase activity	1.63934797352054	bayes_pls_golite062009
structural constituent of ribosome	1.0137045454994	bayes_pls_golite062009
catalytic activity	0.797300463760338	bayes_pls_golite062009
N-methyltransferase activity	0.736216022000293	bayes_pls_golite062009
structural molecule activity	0.694233763389628	bayes_pls_golite062009
binding	0.650146274744039	bayes_pls_golite062009
nucleic acid binding	0.404179021204849	bayes_pls_golite062009
rRNA (guanine) methyltransferase activity	0.319046095835882	bayes_pls_golite062009
	0.16936231012632	bayes_pls_golite062009
snoRNA binding	0.155192244522672	bayes_pls_golite062009
protein binding	0.031057919963412	bayes_pls_golite062009
rRNA (guanine-N1-)-methyltransferase activity	6.26422903788337E-4	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: