YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|24376202, gi\|...
Organism:	Shewanella oneidensis MR-1
Length:	458 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|24376202, gi|....

Description	E-value	Query Range	Subject Range
gi\|26111062, gi\|... - gi\|26250631\|ref\|NP_756671.1\| coproporphyrinogen III oxidase [Escherichia coli CFT073], gi\|26111062\|g...	403.0	[0..6]	[458..7]
gi\|161486044 - gi\|161486044\|ref\|NP_756671.2\| coproporphyrinogen III oxidase [Escherichia coli CFT073] gi\|40889237 - gi\|40889237\|pdb\|1OLT\|A Chain A, Coproporphyrinogen Iii Oxidase (Hemn) From Escherichia Coli Is A Rad... gi\|227837656, gi... - gi\|227885398\|ref\|ZP_04003203.1\| coproporphyrinogen dehydrogenase [Escherichia coli 83972], gi\|227837...	403.0	[0..6]	[458..5]
gi\|226902834, gi... - gi\|237702897\|ref\|ZP_04533378.1\| oxygen-independent coproporphyrinogen III oxidase [Escherichia sp. 3... gi\|115515264, gi... - gi\|117626140\|ref\|YP_859463.1\| coproporphyrinogen III oxidase [Escherichia coli APEC O1], gi\|11551526... gi\|91074987, gi\|... - gi\|91213413\|ref\|YP_543399.1\| coproporphyrinogen III oxidase [Escherichia coli UTI89], gi\|91074987\|gb...	403.0	[0..6]	[458..7]
gi\|16131707, gi\|... - gb\|AAC76864.1\| O2-independent coproporphyrinogen III oxidase [Escherichia coli K12], gi\|16131707\|re... gi\|226838515, gi... - gi\|254039079\|ref\|ZP_04873129.1\| O2-independent coproporphyrinogen III oxidase [Escherichia sp. 1_1_4... gi\|81247622, gi\|... - gi\|82546211\|ref\|YP_410158.1\| O2-independent coproporphyrinogen III oxidase [Shigella boydii Sb227], ... gi\|74314372, gi\|... - gi\|74314372\|ref\|YP_312791.1\| O2-independent coproporphyrinogen III oxidase [Shigella sonnei Ss046], ... gi\|13364265 - gi\|13364265\|dbj\|BAB38212.1\| O2-independent coproporphyrinogen III oxidase [Escherichia coli O157:H7 ... gi\|7427735, gi\|2... - pir\|\|F65191 coproporphyrinogen oxidase (EC 1.3.3.3) III, oxygen-independent - Escherichia coli (stra... gi\|13364265 - gi\|13364265\|dbj\|BAB38212.1\| O2-independent coproporphyrinogen III oxidase [Escherichia coli O157:H7]	401.0	[0..6]	[458..7]
gi\|238902934, gi... - gi\|238902934\|ref\|YP_002928730.1\| coproporphyrinogen III oxidase, SAM and NAD(P)H dependent, oxygen-i... gi\|251787131, gi... - gi\|251787131\|ref\|YP_003001435.1\| hypothetical protein B21_03701 [Escherichia coli BL21], gi\|24237940... gi\|161984816 - gi\|161984816\|ref\|YP_410158.2\| coproporphyrinogen III oxidase [Shigella boydii Sb227] gi\|254290568, gi... - gi\|254290568\|ref\|YP_003056316.1\| coproporphyrinogen III oxidase [Escherichia coli BL21(DE3)], gi\|253... gi\|161986407 - gi\|161986407\|ref\|YP_312791.2\| coproporphyrinogen III oxidase [Shigella sonnei Ss046] gi\|254163818, gi... - gi\|254163818\|ref\|YP_003046926.1\| coproporphyrinogen III oxidase [Escherichia coli B str. REL606], gi... gi\|168748853, gi... - gi\|188016759\|gb\|EDU54881.1\| oxygen-independent coproporphyrinogen III oxidase [Escherichia coli O157... gi\|254595258, gi... - gi\|254795858\|ref\|YP_003080695.1\| coproporphyrinogen III oxidase, SAM and NAD(P)H dependent, oxygen-i... gi\|168755535, gi... - gi\|189357108\|gb\|EDU75527.1\| oxygen-independent coproporphyrinogen III oxidase [Escherichia coli O157... gi\|168761767, gi... - gi\|189367897\|gb\|EDU86313.1\| oxygen-independent coproporphyrinogen III oxidase [Escherichia coli O157... gi\|208728252, gi... - gi\|208808451\|ref\|ZP_03250788.1\| oxygen-independent coproporphyrinogen III oxidase [Escherichia coli ... gi\|208734247, gi... - gi\|208812970\|ref\|ZP_03254299.1\| oxygen-independent coproporphyrinogen III oxidase [Escherichia coli ... gi\|208741095, gi... - gi\|208820972\|ref\|ZP_03261292.1\| oxygen-independent coproporphyrinogen III oxidase [Escherichia coli ... gi\|209157787, gi... - gi\|209396387\|ref\|YP_002273383.1\| oxygen-independent coproporphyrinogen III oxidase [Escherichia coli... gi\|217322657, gi... - gi\|217326436\|ref\|ZP_03442520.1\| oxygen-independent coproporphyrinogen III oxidase [Escherichia coli ... gi\|218556426, gi... - gi\|218556426\|ref\|YP_002389340.1\| coproporphyrinogen III oxidase [Escherichia coli IAI1], gi\|21836319... gi\|218697580, gi... - gi\|218697580\|ref\|YP_002405247.1\| coproporphyrinogen III oxidase [Escherichia coli 55989], gi\|2183543... gi\|168768152, gi... - gi\|189362689\|gb\|EDU81108.1\| oxygen-independent coproporphyrinogen III oxidase [Escherichia coli O157... gi\|168775317, gi... - gi\|187769143\|gb\|EDU32987.1\| oxygen-independent coproporphyrinogen III oxidase [Escherichia coli O157... gi\|189001408, gi... - gi\|189001408\|gb\|EDU70394.1\| oxygen-independent coproporphyrinogen III oxidase [Escherichia coli O157... gi\|189373340, gi... - gi\|189373340\|gb\|EDU91756.1\| oxygen-independent coproporphyrinogen III oxidase [Escherichia coli O157... gi\|168799571, gi... - gi\|189378080\|gb\|EDU96496.1\| oxygen-independent coproporphyrinogen III oxidase [Escherichia coli O157... gi\|169757047, gi... - gi\|170022119\|ref\|YP_001727073.1\| coproporphyrinogen III oxidase [Escherichia coli ATCC 8739], gi\|169... gi\|169891174, gi... - gi\|170083339\|ref\|YP_001732659.1\| coproporphyrinogen III oxidase, SAM and NAD(P)H dependent, oxygen-i... gi\|195937504 - gi\|195937504\|ref\|ZP_03082886.1\| coproporphyrinogen III oxidase [Escherichia coli O157:H7 str. EC4024... gi\|124501232, gi... - gi\|124527530\|ref\|ZP_01698995.1\| oxygen-independent coproporphyrinogen III oxidase [Escherichia coli ... EG11836 - coproporphyrinogen III oxidase, SAM and NAD(P)H dependent, oxygen-independent / Coproporphyrinogen I... gi\|89110161, gi\|... - gi\|89110161\|ref\|AP_003941.1\| coproporphyrinogen III oxidase, SAM and NAD(P)H dependent, oxygen-indep... gi\|192929369, gi... - gi\|75258151\|ref\|ZP_00729612.1\| COG0635: Coproporphyrinogen III oxidase and related Fe-S oxidoreducta... gi\|193068087, gi... - gi\|75238309\|ref\|ZP_00722308.1\| COG0635: Coproporphyrinogen III oxidase and related Fe-S oxidoreducta... EG11836 - coproporphyrinogen III oxidase, SAM and NAD(P)H dependent, oxygen-independent / Coproporphyrinogen I... gi\|188494005, gi... - gi\|75513984\|ref\|ZP_00736337.1\| COG0635: Coproporphyrinogen III oxidase and related Fe-S oxidoreducta... gi\|38704208 - gi\|38704208\|ref\|NP_312816.2\| coproporphyrinogen III oxidase [Escherichia coli O157:H7 str. Sakai] gi\|75197742, gi\|... - gi\|75197742\|ref\|ZP_00707812.1\| COG0635: Coproporphyrinogen III oxidase and related Fe-S oxidoreducta... gi\|157081165, gi... - gi\|75188601\|ref\|ZP_00701868.1\| COG0635: Coproporphyrinogen III oxidase and related Fe-S oxidoreducta... gi\|75230387, gi\|... - gi\|75230387\|ref\|ZP_00716873.1\| COG0635: Coproporphyrinogen III oxidase and related Fe-S oxidoreducta... gi\|194428658, gi... - gi\|75210116\|ref\|ZP_00710295.1\| COG0635: Coproporphyrinogen III oxidase and related Fe-S oxidoreducta... gi\|38704208 - gi\|38704208\|ref\|NP_312816.2\| coproporphyrinogen III oxidase [Escherichia coli O157:H7] gi\|194435183, gi... - gi\|83568941\|ref\|ZP_00920407.1\| COG0635: Coproporphyrinogen III oxidase and related Fe-S oxidoreducta... HEMN_ECOLI - Oxygen-independent coproporphyrinogen III oxidase (EC 1.3.99.22) (Coproporphyrinogenase) (Coprogen o... gi\|187730229, gi... - gi\|75176748\|ref\|ZP_00696876.1\| COG0635: Coproporphyrinogen III oxidase and related Fe-S oxidoreducta... gi\|194422729, gi... - gi\|83586284\|ref\|ZP_00924920.1\| COG0635: Coproporphyrinogen III oxidase and related Fe-S oxidoreducta...	401.0	[0..6]	[458..5]
gi\|82778959, gi\|... - gi\|82778959\|ref\|YP_405308.1\| O2-independent coproporphyrinogen III oxidase [Shigella dysenteriae Sd1...	401.0	[0..6]	[458..7]
gi\|75237832, gi\|... - gi\|75237832\|ref\|ZP_00721847.1\| COG0635: Coproporphyrinogen III oxidase and related Fe-S oxidoreducta... gi\|110644206, gi... - gi\|110644206\|ref\|YP_671936.1\| coproporphyrinogen III oxidase [Escherichia coli 536], gi\|110345798\|gb...	401.0	[0..6]	[458..5]
gi\|15804452, gi\|... - gi\|15804452\|ref\|NP_290492.1\| coproporphyrinogen III oxidase [Escherichia coli O157:H7 EDL933], gi\|12... gi\|25284558 - pir\|\|D86074 O2-independent coproporphyrinogen III oxidase [imported] - Escherichia coli (strain O157...	401.0	[0..6]	[458..7]
gi\|62182466, gi\|... - gi\|62182466\|ref\|YP_218883.1\| coproporphyrinogen III oxidase [Salmonella enterica subsp. enterica ser...	400.0	[0..4]	[458..3]

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Predicted Domain #1

Region A:
Residues: [1-458]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKQPTQISWD QSMIEKYNYS GPRYTSYPTA LEFDDSFTEQ NLLTAIENSK SDKLSLYIHI  60
   61 PFCAKLCYYC GCNKVITRHA HKADQYIEYL SHEIIKRAPL FKHYSVTQMH WGGGTPTFLN 120
  121 PEQIIKLTAL IKANFNFADE GEFSIEVDPR EIELSMLDTL KEAGFNRISI GVQDFNKEVQ 180
  181 VAVNREQDEQ FIFDLMAKAK AMGFVSTNID LIYGLPHQTP ETFAATMQRV LDLSPDRLSV 240
  241 FNYAHLPARF AAQRKIKDEH LPSPKQKLEM LHQTIETLTG AGYQYIGMDH FAKPDDELAK 300
  301 LQREGKLHRN FQGYTTQEEC DLLGLGVSSI SQIGDCYAQN QKDIRPYYEA IDKDGHALWK 360
  361 GCSLNRDDEI RRVVIKQLIC HFDLDMAKID EKLGIKFEEY FAEDLKLLQT FIDDKLVEVA 420
  421 DRKITISPTG RLLIRNICMC FDLYYRQKAR QQQFSRVI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	113.0
Match:	1oltA
Description:	Coproporphyrinogen III oxidase (HemN) from Escherichia coli is a Radical SAM enzyme.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
coproporphyrinogen oxidase activity	2.62711845981655	bayes_pls_golite062009
biotin synthase activity	2.22585029668171	bayes_pls_golite062009
radical SAM enzyme activity	2.08127882819276	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor	1.93818807823452	bayes_pls_golite062009
catalytic activity	1.85375915825216	bayes_pls_golite062009
sulfurtransferase activity	1.26112752511053	bayes_pls_golite062009
transferase activity, transferring sulfur-containing groups	0.35292941647096	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: