YRC Public Data Repository - Protein Structure Prediction

Protein:	HIS7_SHEON
Organism:	Shewanella oneidensis MR-1
Length:	363 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HIS7_SHEON.

Description	E-value	Query Range	Subject Range
gi\|82543399, gi\|... - gi\|82543399\|ref\|YP_407346.1\| imidazole glycerol-phosphate dehydratase/histidinol phosphatase [Shigel...	434.0	[0..9]	[363..1]
gi\|194436088, gi... - gi\|83588023\|ref\|ZP_00926648.1\| COG0131: Imidazoleglycerol-phosphate dehydratase [Escherichia coli 10...	433.0	[0..9]	[363..1]
gi\|187430368, gi... - gi\|75177149\|ref\|ZP_00697247.1\| COG0131: Imidazoleglycerol-phosphate dehydratase [Shigella boydii BS5...	433.0	[0..9]	[363..1]
gi\|83571264, gi\|... - gi\|83571264\|ref\|ZP_00922705.1\| COG0131: Imidazoleglycerol-phosphate dehydratase [Shigella dysenteria...	433.0	[0..9]	[363..1]
gi\|117624225, gi... - gi\|117624225\|ref\|YP_853138.1\| imidazole glycerol-phosphate dehydratase/histidinol phosphatase [Esche... gi\|227887071, gi... - gi\|227887071\|ref\|ZP_04004876.1\| imidazole glycerol-phosphate dehydratase/histidinol phosphatase [Esc... gi\|237704478, gi... - gi\|237704478\|ref\|ZP_04534959.1\| imidazole glycerol-phosphate dehydratase/histidinol phosphatase [Esc...	433.0	[0..9]	[363..1]
gi\|254593204, gi... - gi\|254793804\|ref\|YP_003078641.1\| bifunctional histidinol-phosphatase [Escherichia coli O157:H7 str. ... gi\|189365859, gi... - gi\|189365859\|gb\|EDU84275.1\| histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase [Escheric... gi\|168757564, gi... - gi\|189355448\|gb\|EDU73867.1\| histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase [Escheric... gi\|168751652, gi... - gi\|188014323\|gb\|EDU52445.1\| histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase [Escheric... gi\|161367583 - gi\|161367583\|ref\|NP_288527.2\| imidazole glycerol-phosphate dehydratase/histidinol phosphatase [Esche... gi\|4867934 - gi\|4867934\|dbj\|BAA77743.1\| histidinol-phosphatase and imidazoleglycerol-phosphate dehydratase [Esche... gi\|38704042 - gi\|38704042\|ref\|NP_310850.2\| imidazole glycerol-phosphate dehydratase/histidinol phosphatase [Escher... gi\|217329712, gi... - gi\|217329712\|ref\|ZP_03445791.1\| histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase [Esch... HIS7_ECO57 - Histidine biosynthesis bifunctional protein HisB OS=Escherichia coli O157:H7 GN=hisB PE=1 SV=1 gi\|209162125, gi... - gi\|209400725\|ref\|YP_002271263.1\| histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase [Esc... gi\|208821181, gi... - gi\|208821181\|ref\|ZP_03261501.1\| histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase [Esch... gi\|168788688, gi... - gi\|189371558\|gb\|EDU89974.1\| histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase [Escheric... gi\|168782303, gi... - gi\|189000070\|gb\|EDU69056.1\| histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase [Escheric... gi\|168775532, gi... - gi\|187768978\|gb\|EDU32822.1\| histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase [Escheric... gi\|189361247, gi... - gi\|189361247\|gb\|EDU79666.1\| histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase [Escheric... gi\|208730819, gi... - gi\|208817200\|ref\|ZP_03258292.1\| histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase [Esch... gi\|208727751, gi... - gi\|208807950\|ref\|ZP_03250287.1\| histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase [Esch... gi\|195939360 - gi\|195939360\|ref\|ZP_03084742.1\| imidazole glycerol-phosphate dehydratase/histidinol phosphatase [Esc... gi\|168799098, gi... - gi\|189378402\|gb\|EDU96818.1\| histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase [Escheric...	433.0	[0..9]	[363..1]
EG10445 - histidinol-phosphatase and imidazoleglycerol-phosphate dehydratase / Imidazoleglycerolphosphate dehy... HIS7_ECOLI - Histidine biosynthesis bifunctional protein hisB [Includes: Histidinol-phosphatase (EC 3.1.3.15); Im... EG10445 - histidinol-phosphatase and imidazoleglycerol-phosphate dehydratase / Imidazoleglycerolphosphate dehy... gi\|238861198, gi... - gi\|238901213\|ref\|YP_002927009.1\| fused histidinol-phosphatase/imidazoleglycerol-phosphate dehydratas... gi\|89108843, gi\|... - gi\|89108843\|ref\|AP_002623.1\| fused histidinol-phosphatase and imidazoleglycerol-phosphate dehydratas... gi\|169889488, gi... - gi\|170081653\|ref\|YP_001730973.1\| fused histidinol-phosphatase; imidazoleglycerol-phosphate dehydrata...	433.0	[0..9]	[363..1]
gi\|25291876, gi\|... - gi\|25291876\|pir\|\|E85827 hypothetical protein hisB [imported] - Escherichia coli (strain O157:H7, su... gi\|12516203, gi\|... - gi\|15802501\|ref\|NP_288527.1\| imidazole glycerol-phosphate dehydratase/histidinol phosphatase [Escher... gi\|13362291 - gi\|13362291\|dbj\|BAB36246.1\| imidazoleglycerolphosphate dehydratase / histidinol-phosphate phosphatas... gi\|13362291 - gi\|13362291\|dbj\|BAB36246.1\| imidazoleglycerolphosphate dehydratase / histidinol-phosphate phosphatas...	433.0	[0..9]	[363..2]
gi\|75514063, gi\|... - gi\|75514063\|ref\|ZP_00736393.1\| COG0131: Imidazoleglycerol-phosphate dehydratase [Escherichia coli 53...	433.0	[0..9]	[363..1]
gi\|157161515, gi... - gi\|75196089\|ref\|ZP_00706159.1\| COG0131: Imidazoleglycerol-phosphate dehydratase [Escherichia coli HS...	432.0	[0..9]	[363..1]

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Predicted Domain #1

Region A:
Residues: [1-171]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNPVFTPNVA QKILFIDRDG TLIEEPVTDK QVDNLAKLVF EPQVIPALLR LQKAGFRLVM  60
   61 VSNQDGLGTP SFPQEDFDAP HNMMMQILSS QGVKFEDVLI CPHFNDENCS CRKPKLGLVK 120
  121 DFLTQGFIDF TQSAVIGDRH TDVELGNAMG IISFQYQRGS LGWNAIADAL L

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	26.522879
Match:	2fprA
Description:	No description for 2fprA was found.

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.55296860681783	bayes_pls_golite062009
binding	0.403742083069476	bayes_pls_golite062009
nucleic acid binding	0.311168802206529	bayes_pls_golite062009
imidazoleglycerol-phosphate dehydratase activity	0.194869838584556	bayes_pls_golite062009
phosphatase activity	0.159899259988948	bayes_pls_golite062009
phosphoric ester hydrolase activity	0.103902756538853	bayes_pls_golite062009
hydrolase activity	0.01837003348146	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [172-363]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKGRSATVVR TTKETDIRVT VDLDNASKGT INTGIGFFDH MLDQIATHGN FKMEVNVDGD  60
   61 LEIDDHHSVE DTALAIGDAL RQALGDKRGI ARFGFSLPMD EAKGECLLDL SGRPFIKFAA 120
  121 QFEREKVGEM ATEMVPHFFR SFADGLRCTL HVAAEGDNDH HKVEALFKVL GRALRQAVKV 180
  181 EGDVLPSSKG VL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	83.39794
Match:	2f1dA
Description:	X-Ray Structure of imidazoleglycerol-phosphate dehydratase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
imidazoleglycerol-phosphate dehydratase activity	1.6337728630325	bayes_pls_golite062009
carbohydrate kinase activity	0.89499871627607	bayes_pls_golite062009
catalytic activity	0.878454819018611	bayes_pls_golite062009
binding	0.806477220933291	bayes_pls_golite062009
nucleic acid binding	0.417420176258912	bayes_pls_golite062009
structural constituent of ribosome	0.325699575011026	bayes_pls_golite062009
transcription regulator activity	0.212099606954236	bayes_pls_golite062009
structural molecule activity	2.19428886088058E-4	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: