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View Structure Prediction Details

Protein: ULP1_YEAST
Organism: Saccharomyces cerevisiae S288c
Length: 621 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ULP1_YEAST.

Description E-value Query
Range
Subject
Range
ULP1_YEAST - Ubiquitin-like-specific protease 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ULP1 ...
ULP1 - Ubl (ubiquitin-like protein)-specific protease that cleaves Smt3p protein conjugates; specifically r...
0.0 [1..621] [1..621]
gi|15217714 - gi|15217714|ref|NP_174099.1| Ulp1 protease family protein [Arabidopsis thaliana]
2.0E-98 [39..618] [583..1187]
SENP2 - SUMO1/sentrin/SMT3 specific peptidase 2
5.0E-97 [66..620] [32..588]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
6.0E-96 [39..618] [583..1187]
SENP2_MOUSE - Sentrin-specific protease 2 OS=Mus musculus GN=Senp2 PE=1 SV=2
3.0E-95 [50..620] [20..587]

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Predicted Domain #1
Region A:
Residues: [1-153]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVEVDKHRN TLQYHKKNPY SPLFSPISTY RCYPRVLNNP SESRRSASFS GIYKKRTNTS  60
   61 RFNYLNDRRV LSMEESMKDG SDRASKAGFI GGIRETLWNS GKYLWHTFVK NEPRNFDGSE 120
  121 VEASGNSDVE SRSSGSRSSD VPYGLRENYS SDT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [154-263]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RKHKFDTSTW ALPNKRRRIE SEGVGTPSTS PISSLASQKS NCDSDNSITF SRDPFGWNKW  60
   61 KTSAIGSNSE NNTSDQKNSY DRRQYGTAFI RKKKVAKQNI NNTKLVSRAQ 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.431 0.234 nuclear pore a.118.1 ARM repeat
View Download 0.317 0.179 SUMO-specific protease activity b.40.4 Nucleic acid-binding proteins
View Download 0.389 0.139 SUMO-specific protease activity a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.433 0.095 SUMO-specific protease activity a.138.1 Multiheme cytochromes
View Download 0.353 0.038 SUMO-specific protease activity a.77.1 DEATH domain
View Download 0.242 N/A N/A d.217.1 SAND domain-like
View Download 0.238 N/A N/A d.79.3 L30e-like
View Download 0.234 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.233 N/A N/A a.39.1 EF-hand
View Download 0.232 N/A N/A a.3.1 Cytochrome c
View Download 0.216 N/A N/A a.92.1 Carbamoyl phosphate synthetase, large subunit connection domain
View Download 0.212 N/A N/A a.5.3 N-terminal domain of phosphatidylinositol transfer protein sec14p

Predicted Domain #3
Region A:
Residues: [264-391]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SEEVTYLRQI FNGEYKVPKI LKEERERQLK LMDMDKEKDT GLKKSIIDLT EKIKTILIEN  60
   61 NKNRLQTRNE NDDDLVFVKE KKISSLERKH KDYLNQKLKF DRSILEFEKD FKRYNEILNE 120
  121 RKKIQEDL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.586 0.009 SUMO-specific protease activity a.118.8 TPR-like
View Download 0.554 0.009 SUMO-specific protease activity a.24.3 Cytochromes
View Download 0.626 0.009 SUMO-specific protease activity a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.905 0.009 SUMO-specific protease activity f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.743 0.009 SUMO-specific protease activity a.90.1 Transcription factor STAT-4 N-domain
View Download 0.494 0.009 SUMO-specific protease activity a.47.2 t-snare proteins
View Download 0.465 0.009 SUMO-specific protease activity a.24.4 Hemerythrin
View Download 0.375 0.009 SUMO-specific protease activity a.25.1 Ferritin-like
View Download 0.374 0.009 SUMO-specific protease activity a.24.9 alpha-catenin/vinculin
View Download 0.362 0.009 SUMO-specific protease activity a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.358 0.009 SUMO-specific protease activity a.25.1 Ferritin-like
View Download 0.342 0.009 SUMO-specific protease activity a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.337 0.009 SUMO-specific protease activity a.118.1 ARM repeat
View Download 0.322 0.009 SUMO-specific protease activity a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.318 0.009 SUMO-specific protease activity a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.313 0.009 SUMO-specific protease activity i.11.1 Computational models partly based on NMR data
View Download 0.276 0.009 SUMO-specific protease activity c.23.8 N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)
View Download 0.266 0.009 SUMO-specific protease activity a.25.1 Ferritin-like
View Download 0.261 0.009 SUMO-specific protease activity a.3.1 Cytochrome c
View Download 0.257 0.009 SUMO-specific protease activity c.59.1 MurD-like peptide ligases, peptide-binding domain
View Download 0.220 0.009 SUMO-specific protease activity a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.202 0.009 SUMO-specific protease activity f.14.1 Voltage-gated potassium channels

Predicted Domain #4
Region A:
Residues: [392-621]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKKKEQLAKK KLVPELNEKD DDQVQKALAS RENTQLMNRD NIEITVRDFK TLAPRRWLND  60
   61 TIIEFFMKYI EKSTPNTVAF NSFFYTNLSE RGYQGVRRWM KRKKTQIDKL DKIFTPINLN 120
  121 QSHWALGIID LKKKTIGYVD SLSNGPNAMS FAILTDLQKY VMEESKHTIG EDFDLIHLDC 180
  181 PQQPNGYDCG IYVCMNTLYG SADAPLDFDY KDAIRMRRFI AHLILTDALK 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1309.30103
Match: 1euvA_
Description: Ulp1 protease C-terminal domain
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle