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View Structure Prediction Details

Protein: SKN7_YEAST
Organism: Saccharomyces cerevisiae S288c
Length: 622 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SKN7_YEAST.

Description E-value Query
Range
Subject
Range
SKN7 - Nuclear response regulator and transcription factor, part of a branched two-component signaling syst...
SKN7_YEAST - Transcription factor SKN7 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SKN7 PE=1 SV=1
gi|151944151 - gi|151944151|gb|EDN62444.1| suppressor of kre null [Saccharomyces cerevisiae YJM789]
0.0 [1..622] [1..622]
HSF1_CHICK - Heat shock factor protein 1 OS=Gallus gallus GN=HSF1 PE=2 SV=1
1.0E-89 [65..434] [1..395]
gi|10175779, gi|... - gi|15615719|ref|NP_244023.1| two-component response regulator involved in phosphate regulation [Baci...
gi|25300880 - pir||E84044 two-component response regulator involved in phosphate regulation phoP [imported] - Baci...
4.0E-88 [375..611] [1..239]
HSF1 - heat shock transcription factor 1
gi|61362382, gi|... - gi|61362386|gb|AAX42211.1| heat shock transcription factor 1 [synthetic construct], gi|61362382|gb|A...
3.0E-87 [73..374] [4..293]
gi|447739 - gi|447739|prf||1915304A nylB upstream ORF
3.0E-87 [73..374] [4..293]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
1.0E-86 [378..608] [5..234]
gi|25301054 - pir||AG1955 two-component response regulator alr1194 [imported] - Nostoc sp. (strain PCC 7120)
gi|17130541, gi|... - gi|17228689|ref|NP_485237.1| two-component response regulator [Nostoc sp. PCC 7120], gi|17130541|dbj...
1.0E-86 [375..607] [1..225]
gi|25300922 - pir||G97109 response regulator (CheY-like receiver domain and DNA-binding HTH domain) [imported] - C...
gi|15894977, gi|... - gi|15894977|ref|NP_348326.1| response regulator [Clostridium acetobutylicum ATCC 824], gi|15024664|g...
3.0E-86 [378..604] [5..227]
gi|4982229, gi|1... - gi|4982229|gb|AAD36722.1|AE001807_13 response regulator DrrA [Thermotoga maritima MSB8], gi|15644403...
gi|7444020 - pir||D72228 response regulator DrrA - Thermotoga maritima (strain MSB8)
4.0E-86 [377..607] [12..243]
gi|1575577 - gi|1575577|gb|AAC44436.1| DNA-binding response regulator [Thermotoga maritima]
8.0E-86 [377..607] [4..235]

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Predicted Domain #1
Region A:
Residues: [1-67]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFSTINSNV NKTTGDSNNN TTENSSTADL LGMDLLQSGP RLMNTMQPNN SSDMLHINNK  60
   61 TNNVQQP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.55329976718261 bayes_pls_golite062009
DNA binding 4.84466441605416 bayes_pls_golite062009
nucleic acid binding 4.57954522145536 bayes_pls_golite062009
transcription factor activity 4.12685284895733 bayes_pls_golite062009
binding 3.52874320222492 bayes_pls_golite062009
sequence-specific DNA binding 2.3918869755162 bayes_pls_golite062009
transcription activator activity 2.37668609508629 bayes_pls_golite062009
transcription repressor activity 2.22485867684613 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.70025468248325 bayes_pls_golite062009
transcription factor binding 0.85714789329232 bayes_pls_golite062009
protein binding 0.753698599635855 bayes_pls_golite062009
two-component response regulator activity 0.290986349914258 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [68-201]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AGNTNISSAN AGAKAPANEF VRKLFRILEN NEYPDIVTWT ENGKSFVVLD TGKFTTHILP  60
   61 NHFKHSNFAS FVRQLNKYDF HKVKRSPEER QRCKYGEQSW EFQHPEFRVH YGKGLDNIKR 120
  121 KIPAQRKVLL DESQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 200.9897
Match: 1hks__
Description: Heat-shock transcription factor
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [202-369]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KALLHFNSEG TNPNNPSGSL LNESTTELLL SNTVSKDAFG NLRRRVDKLQ KELDMSKMES  60
   61 YATKVELQKL NSKYNTVIES LITFKTINEN LLNNFNTLCS TLANNGIEVP IFGDNGNRNP 120
  121 TGNTNPATTT AIQSNNNTNN ASPATSTVSL QLPNLPDQNS LTPNAQNN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [370-500]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TVTLRKGFHV LLVEDDAVSI QLCSKFLRKY GCTVQVVSDG LSAISTLEKY RYDLVLMDIV  60
   61 MPNLDGATAT SIVRSFDNET PIIAMTGNIM NQDLITYLQH GMNDILAKPF TRDDLHSILI 120
  121 RYLKDRIPLC E

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 122.232149
Match: 1kgsA_
Description: PhoB; PhoB receiver domain
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [501-622]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QQLPPRNSSP QTHSNTNTAN SNPNTINEQS LAMLPQDNPS TTTPVTPGAS ISSAQHVQQG  60
   61 QQEQQHQIFH AQQQQQHHNA IANARSDVAI PNLEHEINTV PHSSMGSTPQ LPQSTLQENQ 120
  121 LS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 122.232149
Match: 1kgsA_
Description: PhoB; PhoB receiver domain
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle