YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|254684127
Organism:	Bacillus anthracis str. CNEVA-9066
Length:	867 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|254684127.

Description	E-value	Query Range	Subject Range
gi\|42739428, gi\|... - gi\|42783499\|ref\|NP_980746.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Bacillus cereus AT...	0.0	[1..867]	[1..867]
gi\|49476825, gi\|... - gi\|49476825\|ref\|YP_038422.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Bacillus thuringie...	0.0	[15..867]	[15..867]
gi\|30022446, gi\|... - gi\|30022446\|ref\|NP_834077.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Bacillus cereus AT... gi\|228653768, gi... - gi\|229129651\|ref\|ZP_04258619.1\| Alcohol dehydrogenase, iron-containing [Bacillus cereus BDRD-Cer4], ...	0.0	[18..867]	[18..867]
gi\|51974605, gi\|... - gi\|52141136\|ref\|YP_085694.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Bacillus cereus E3...	0.0	[15..867]	[15..867]
gi\|114845300, gi... - gi\|167039286\|ref\|YP_001662271.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Thermoanaeroba...	0.0	[15..864]	[24..870]
gi\|241903602, gi... - gi\|241903602\|ref\|ZP_04788323.1\| iron-containing alcohol dehydrogenase [Thermoanaerobacter brockii su... gi\|76588428, gi\|... - gi\|76796158\|ref\|ZP_00778525.1\| Iron-containing alcohol dehydrogenase [Thermoanaerobacter ethanolicus...	0.0	[15..864]	[24..870]
gi\|52005783, gi\|... - gi\|52787967\|ref\|YP_093796.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Bacillus lichenifo...	0.0	[18..866]	[18..866]
gi\|111143367 - gi\|111143367\|gb\|ABH06551.1\| alcohol/aldehyde dehydrogenase [Thermoanaerobacter ethanolicus]	0.0	[17..864]	[26..872]
gi\|89210581, gi\|... - gi\|89210581\|ref\|ZP_01188969.1\| Iron-containing alcohol dehydrogenase:Aldehyde dehydrogenase [Halothe...	0.0	[15..866]	[27..875]
gi\|163942121, gi... - gi\|89206333\|ref\|ZP_01184893.1\| Iron-containing alcohol dehydrogenase:Aldehyde dehydrogenase [Bacillu...	0.0	[15..866]	[15..866]

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Predicted Domain #1

Region A:
Residues: [1-455]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVVKEKVVNE MQEVKEMIDT LVNNGRKALQ ALESFTQEQI DNIVHEMALA GVDQHMPLAK  60
   61 LAVEETGRGV YEDKCIKNIF ATEYIWHSIK KDKTVGIIHE DPHEEIIEIA EPVGVVAGVT 120
  121 PVTNPTSTTM FKALIAIKTR NPIIFAFHPS AQNCSVAAAK TVYDAAVKAG APKHCIQWIE 180
  181 KPSVEATKQL MNHEGVALVL ATGGAGMVKS AYSTGKPALG VGPGNVPCYI EKSAHIKRAV 240
  241 NDLILSKTFD NGMICASEQA IIVDKEIYDD VKTEMITNDC YFVTEEERRK LEKLVINENT 300
  301 CAVNSDIVGK SAQYIAELVG ITVPKNTKML VAEIQGIGAA YPLSREKLSP VLACVKANSL 360
  361 EEGFTYCEEM LNLGGLGHSA VIHSVNKEVQ KQFGLRMKAC RLIVNAPSSQ GGIGDIYNGF 420
  421 IPSLTLGCGS YGKNSVSQNV TATHLLNIKR LANRK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	139.0
Match:	1bxsA
Description:	Aldehyde reductase (dehydrogenase), ALDH
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity	4.47226217021998	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	4.34495776828926	bayes_pls_golite062009
3-chloroallyl aldehyde dehydrogenase activity	3.37049090049734	bayes_pls_golite062009
succinate-semialdehyde dehydrogenase [NAD(P)+] activity	3.30681232755737	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	3.2867555127991	bayes_pls_golite062009
aldehyde dehydrogenase (NAD) activity	2.81851373615334	bayes_pls_golite062009
catalytic activity	2.80804701752928	bayes_pls_golite062009
succinate-semialdehyde dehydrogenase activity	2.25908515251731	bayes_pls_golite062009
benzaldehyde dehydrogenase activity	1.80313175632526	bayes_pls_golite062009
methylmalonate-semialdehyde dehydrogenase (acylating) activity	1.59279206536309	bayes_pls_golite062009
1-pyrroline-5-carboxylate dehydrogenase activity	1.15620590715864	bayes_pls_golite062009
binding	0.637403449596354	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [456-867]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KNMQWFKLPP KIYFEKHATA YLANMPNISR AFIVTDPGMV EHGYVDTVAH YLRKHANDVK  60
   61 VEVFFEVEPD PSDETVFKGA EMMRSFQPDV IIALGGGSAM DAAKGMWLFY EYPETTFYGI 120
  121 KQKFLDIRKR TCKYPELGSK AQFVAIPTTS GTGSEVTPFA VITDKKNNIK YPLADYELTP 180
  181 DVAIVDPQFV MTVPPHVTAD TGMDVLTHAI EAYVSVLAND YTDGLALKAI DLVFKYLPRA 240
  241 FKDGHDEEAR EKMHNASAIA GMAFANAFLG INHSLAHKIG PEFHIPHGRA NAILMPHVIR 300
  301 YNAIKPRKHA LFPKYEHFVA DERYAHIARM LGLPASSVAE GVESLDKAII DLGKSLNINM 360
  361 SIAGQGVAKD QFEEVVGLLA ERAFEDQCTT ANPKLPLISE LKEIYMKAYK GE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	91.30103
Match:	1rrmA
Description:	Crystal Structure of Lactaldehyde reductase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
hydroxyacid-oxoacid transhydrogenase activity	8.51876704052427	bayes_pls_golite062009
alcohol dehydrogenase (NAD) activity	5.26400058766942	bayes_pls_golite062009
oxidoreductase activity	3.07409531087588	bayes_pls_golite062009
alcohol dehydrogenase activity, metal ion-independent	3.05722501802075	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	2.83823088483915	bayes_pls_golite062009
catalytic activity	2.37357608468991	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	2.10085302216488	bayes_pls_golite062009
binding	1.15096180564234	bayes_pls_golite062009
3-chloroallyl aldehyde dehydrogenase activity	0.831155115586418	bayes_pls_golite062009
cation binding	0.319000821544479	bayes_pls_golite062009
metal ion binding	0.319000821544479	bayes_pls_golite062009
ion binding	0.313606245452103	bayes_pls_golite062009
protein binding	0.295023706645045	bayes_pls_golite062009
transition metal ion binding	0.259889634539407	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	0.0904828025133766	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: