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View Structure Prediction Details

Protein: gi|254071455, gi...
Organism: synthetic construct
Length: 227 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|254071455, gi....

Description E-value Query
Range		 Subject
Range
gi|149053384, gi... - gi|62656536|ref|XP_573140.1| PREDICTED: similar to candidate tumor suppressor OVCA2 [Rattus norvegic...
 1.0E-44 [1..227] [1..227]
gi|157169860 - gi|157169860|gb|AAI52881.1| Candidate tumor suppressor in ovarian cancer 2 [synthetic construct]
OVCA2_MOUSE - Esterase OVCA2 OS=Mus musculus GN=Ovca2 PE=1 SV=1
 5.0E-44 [1..227] [1..225]
OVCA2_BOVIN - Esterase OVCA2 OS=Bos taurus GN=OVCA2 PE=2 SV=1
 2.0E-39 [1..226] [1..226]
gi|26996895 - gi|26996895|gb|AAH40696.1| Candidate tumor suppressor in ovarian cancer 2 [Homo sapiens]
 2.0E-38 [1..227] [1..227]
gi|50737613 - gi|50737613|ref|XP_419203.1| PREDICTED: similar to Acyl-protein thioesterase 1 (Lysophospholipase I)...
 3.0E-37 [4..226] [19..225]

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Predicted Domain #1
Region A:
Residues: [1-227] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAQRPLRVL CLAGFRQSER GFREKTGALR KALRGRAELV CLSGPHPVPD PPGPEGARSD  60
   61 FGSCPPEEQP RGWWFSEQEA DVFSALEEPA VCRGLEESLG MVAQALNRLG PFDGLLGFSQ 120
  121 GAALAALVCA LGQAGDPRFP LPRFILLVSG FCPRGIGFKE SILQRPLSLP SLHVFGDTDK 180
  181 VIPSQESVQL ASQFPGAITL THSGGHFIPA AAPQRQAYLK FLDQFAE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 36.522879
Match: 1fj2A
Description: Acyl protein thioesterase 1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
hydrolase activity 0.900012765484033 bayes_pls_golite062009
catalytic activity 0.629869101256762 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 0.475177657121888 bayes_pls_golite062009
binding 0.424949448217625 bayes_pls_golite062009
carboxylesterase activity 0.0264147222103929 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle