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View Structure Prediction Details

Protein: eps-8
Organism: Caenorhabditis elegans
Length: 740 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for eps-8.

Description E-value Query
Range
Subject
Range
eps-8 - status:Confirmed UniProt:Q6IZD5 protein_id:CAJ44243.1
649.0 [0..1] [729..1]

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Predicted Domain #1
Region A:
Residues: [1-79]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRRGGSMGPP SGDPYQSRPS PGGYYYNRST PGGQPAPSPS HSQQSASSHH PRGVPMSQPI  60
   61 ARRSDYRTGS EQMTPRSDH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [80-252]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RGPSMGYGNG GSVDQRVDDV TPSYYVEHLA TFAVGRQFGL TFPADGIRKL KQMEKNSAIW  60
   61 AQPLILRFRH NAVTVEDDNG ELVEQFPLEL IEQPTAHVSN DSRETYNNVL LFVVREDRKR 120
  121 MSTPTEMHIF QCIRVSATDV AEDLKNYVQG QFRRVRNGRR TAAPTHLQAQ QQQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 55.0
Match: 2cy4A
Description: Crystal structure of phosphotyrosine binding (PTB) domain of epidermal growth factor receptor pathway substrate-8 (EPS8) related protein 1 from Mus musculus (form-1 crystal)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.597587183571285 bayes_pls_golite062009
protein binding 0.29116370406325 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [253-559]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPFYPPDDAS ISSETSEMFE RDVNTLNRCF DDIERFVARI QSAALAQREI EQQNHRYRTA  60
   61 NRRDKKNQQP PDPNGILFMR AQLPLESEFV DILKKFKLSF NLLAKLKNHI HEPNAPELLH 120
  121 FLFTPLAVIL EACHWGLGRN VAPTVASPLL SLEARELMQN CLTSHESDIW MSLGEAWRTP 180
  181 PEDWTKPLPP PYRPIFNDGF APYGVADRAM ATPNQIHRGH SAPPEHFRQP PPRERNMVDT 240
  241 APNTPQSMQR TPKSRPPHRN MSVDNLEFDR LTLERERLEF EKAKIMERES RLRHEEKQIE 300
  301 DEKRRMH

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.02
Match: 2eyzA
Description: No description for 2eyzA was found.

Predicted Domain #4
Region A:
Residues: [560-740]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AEKDLITKET TQPVPPPAAV VTHQPITKRY DPPISISPPP QRNNYSHVKV TVDSDTSPRQ  60
   61 QAFIDDIVAK GGKLAVVTYD RGGQNTKELT VHKGEYLEVI FDERNWWECK NMHQRVGYVP 120
  121 HTILSMVPFE QQQYASPNHH NNSSSTGGYN NGHHQGPGML PEDAPSYVKE RQGKRGEFRY 180
  181 F

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 28.221849
Match: 2h8hA
Description: No description for 2h8hA was found.

Predicted functions:

Term Confidence Notes
binding 0.375837873453985 bayes_pls_golite062009
protein binding 0.25580402341401 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle