YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|188595820, gi...
Organism:	Homo sapiens
Length:	367 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|188595820, gi....

Description	E-value	Query Range	Subject Range
gi\|114663599 - gi\|114663599\|ref\|XP_001171588.1\| PREDICTED: similar to Chain A, Human Dihydroorotate Dehydrogenase C...	307.0	[0..1]	[367..1]
DHODH - dihydroorotate dehydrogenase	306.0	[0..1]	[367..30]
PYRD_PONAB - Dihydroorotate dehydrogenase (quinone), mitochondrial OS=Pongo abelii GN=DHODH PE=2 SV=1 PYRD_PONPY - Dihydroorotate dehydrogenase, mitochondrial precursor - Pongo pygmaeus (Orangutan)	303.0	[0..1]	[367..29]
gi\|109129102 - gi\|109129102\|ref\|XP_001104448.1\| PREDICTED: similar to dihydroorotate dehydrogenase isoform 1 precur...	302.0	[0..1]	[367..29]
gi\|47169294, gi\|... - gi\|47169294\|pdb\|1UUO\|A Chain A, Rat Dihydroorotate Dehydrogenase (Dhod)in Complex With Brequinar, gi...	300.0	[0..2]	[367..7]
gi\|110665638 - gi\|110665638\|gb\|ABG81465.1\| dihydroorotate dehydrogenase precursor [Bos taurus]	298.0	[0..2]	[367..28]
PYRD_RAT - Dihydroorotate dehydrogenase (quinone), mitochondrial OS=Rattus norvegicus GN=Dhodh PE=1 SV=1 gi\|4379422 - emb\|CAA56765.1\| dihydroorotate dehydrogenase [Rattus rattus]	297.0	[0..2]	[367..30]

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Predicted Domain #1

Region A:
Residues: [1-367]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATGDERFYA EHLMPTLQGL LDPESAHRLA VRFTSLGLLP RARFQDSDML EVRVLGHKFR  60
   61 NPVGIAAGFD KHGEAVDGLY KMGFGFVEIG SVTPKPQEGN PRPRVFRLPE DQAVINRYGF 120
  121 NSHGLSVVEH RLRARQQKQA KLTEDGLPLG VNLGKNKTSV DAAEDYAEGV RVLGPLADYL 180
  181 VVNVSSPNTA GLRSLQGKAE LRRLLTKVLQ ERDGLRRVHR PAVLVKIAPD LTSQDKEDIA 240
  241 SVVKELGIDG LIVTNTTVSR PAGLQGALRS ETGGLSGKPL RDLSTQTIRE MYALTQGRVP 300
  301 IIGVGGVSSG QDALEKIRAG ASLVQLYTAL TFWGPPVVGK VKRELEALLK EQGFGGVTDA 360
  361 IGADHRR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	83.39794
Match:	1d3gA
Description:	Dihydroorotate dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity	2.7385769437489	bayes_pls_golite062009
dihydroorotate dehydrogenase activity	2.73800716363956	bayes_pls_golite062009
dihydroorotate oxidase activity	2.35584458985229	bayes_pls_golite062009
catalytic activity	1.94749091175302	bayes_pls_golite062009
dihydropyrimidine dehydrogenase (NADP+) activity	1.76080169529176	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor	0.962937319088834	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors	0.876786102965635	bayes_pls_golite062009
nucleic acid binding	0.126127705865716	bayes_pls_golite062009
binding	0.100344139383616	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: