YRC Public Data Repository - Protein Structure Prediction

Protein:	PPAC_STRP4
Organism:	Streptococcus pneumoniae G54
Length:	311 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PPAC_STRP4.

Description	E-value	Query Range	Subject Range
gi\|262283213\|ref... - inorganic pyrophosphatase [Streptococcus sp. 2_1_36FAA] gi\|56966963, gi\|... - gi\|56966964\|pdb\|1WPP\|B Chain B, Structure Of Streptococcus Gordonii Inorganic Pyrophosphatase, gi\|56...	309.0	[0..1]	[311..1]
gi\|16974962, gi\|... - gi\|16974963\|pdb\|1K20\|B Chain B, Inorganic Pyrophosphatase (Family Ii) From Streptococcus Gordonii At...	306.0	[0..2]	[311..1]
PPAC_STRA3 - Probable manganese-dependent inorganic pyrophosphatase OS=Streptococcus agalactiae serotype III GN=p... gi\|77413364, gi\|... - gi\|77413364\|ref\|ZP_00789558.1\| inorganic pyrophosphatase, manganese-dependent [Streptococcus agalact... PPAC_STRA3 - Probable manganese-dependent inorganic pyrophosphatase OS=Streptococcus agalactiae serotype III (str...	304.0	[0..1]	[311..1]
PPAC_STRA1 - Probable manganese-dependent inorganic pyrophosphatase OS=Streptococcus agalactiae serotype Ia (stra... PPAC_STRA5 - Probable manganese-dependent inorganic pyrophosphatase OS=Streptococcus agalactiae serotype V (strai... gi\|76797681, gi\|... - gi\|76797681\|ref\|ZP_00779950.1\| Manganese-dependent inorganic pyrophosphatase(Pyrophosphate phospho-h... gi\|77411519, gi\|... - gi\|77411519\|ref\|ZP_00787863.1\| inorganic pyrophosphatase, manganese-dependent [Streptococcus agalact... PPAC_STRA1 - Probable manganese-dependent inorganic pyrophosphatase OS=Streptococcus agalactiae serotype Ia GN=pp... gi\|77175621, gi\|... - gi\|77405764\|ref\|ZP_00782849.1\| inorganic pyrophosphatase, manganese-dependent [Streptococcus agalact... PPAC_STRA5 - Probable manganese-dependent inorganic pyrophosphatase OS=Streptococcus agalactiae serotype V GN=ppa...	304.0	[0..1]	[311..1]
gi\|77172760, gi\|... - gi\|77408642\|ref\|ZP_00785376.1\| inorganic pyrophosphatase, manganese-dependent [Streptococcus agalact...	303.0	[0..1]	[311..1]
gi\|55738334, gi\|... - gb\|AAV61975.1\| manganese-dependent inorganic pyrophosphatase [Streptococcus thermophilus CNRZ1066],... PPAC_STRT1 - Probable manganese-dependent inorganic pyrophosphatase OS=Streptococcus thermophilus (strain CNRZ 10... PPAC_STRT2 - Probable manganese-dependent inorganic pyrophosphatase OS=Streptococcus thermophilus (strain ATCC BA...	301.0	[0..1]	[310..1]
PPAC_STRTD - Probable manganese-dependent inorganic pyrophosphatase OS=Streptococcus thermophilus (strain ATCC BA...	301.0	[0..1]	[310..1]
gi\|80977000, gi\|... - gi\|81096958\|ref\|ZP_00875279.1\| Inorganic diphosphatase [Streptococcus suis 89/1591], gi\|80977000\|gb\|...	301.0	[0..1]	[311..1]
PPAC_STRPG - Probable manganese-dependent inorganic pyrophosphatase OS=Streptococcus pyogenes serotype M5 (strain... PPAC_STRP8 - Probable manganese-dependent inorganic pyrophosphatase OS=Streptococcus pyogenes serotype M18 (strai... PPAC_STRPQ - Probable manganese-dependent inorganic pyrophosphatase OS=Streptococcus pyogenes serotype M3 (strain... PPAC_STRP3 - Probable manganese-dependent inorganic pyrophosphatase OS=Streptococcus pyogenes serotype M3 GN=ppaC... gi\|13621631, gi\|... - gi\|15674527\|ref\|NP_268701.1\| putative manganese-dependent inorganic pyrophosphatase [Streptococcus p... PPAC_STRP6 - Probable manganese-dependent inorganic pyrophosphatase OS=Streptococcus pyogenes serotype M6 GN=ppaC... gi\|71852915, gi\|... - gi\|71910133\|ref\|YP_281683.1\| putative manganese-dependent inorganic pyrophosphatase [Streptococcus p... PPAC_STRPY - (P65757) Probable manganese-dependent inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-... PPAC_STRP8 - Probable manganese-dependent inorganic pyrophosphatase OS=Streptococcus pyogenes serotype M18 GN=ppa... PPAC_STRP6 - Probable manganese-dependent inorganic pyrophosphatase OS=Streptococcus pyogenes serotype M6 (strain... PPAC_STRP3 - Probable manganese-dependent inorganic pyrophosphatase OS=Streptococcus pyogenes serotype M3 (strain... PPAC_STRP1 - Probable manganese-dependent inorganic pyrophosphatase OS=Streptococcus pyogenes serotype M1 GN=ppaC...	296.0	[0..1]	[311..1]

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Predicted Domain #1

Region A:
Residues: [1-311]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKILVFGHQ NPDSDAIGSS VAFAYLAKEA YGLDTEAVAL GTPNEETAFV LNYFGVEAPR  60
   61 VITSAKAEGA EQVILTDHNE FQQSVSDIAE VEVYGVVDHH RVANFETASP LYMRLEPVGS 120
  121 ASSIVYRMFK EHGVAVPKEI AGLMLSGLIS DTLLLKSPTT HPTDKIIAPE LAELAGVNLE 180
  181 EYGLAMLKAG TNLASKSAEE LIDIDAKTFE LNGNNVRVAQ VNTVDIAEVL ERQAEIEAAM 240
  241 QAANESNGYS DFVLMITDIV NSNSEILALG ANMDKVEAAF NFKLENNHAF LAGAVSRKKQ 300
  301 VVPQLTESFN A

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	84.39794
Match:	1wppA
Description:	Structure of Streptococcus gordonii inorganic pyrophosphatase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.78154379547895	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	1.30887439158217	bayes_pls_golite062009
hydrolase activity	0.85363015434459	bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	0.648027091973004	bayes_pls_golite062009
deoxyribonuclease activity	0.610962701958695	bayes_pls_golite062009
exonuclease activity	0.596639519476561	bayes_pls_golite062009
binding	0.585481144055308	bayes_pls_golite062009
nuclease activity	0.463328502877406	bayes_pls_golite062009
exodeoxyribonuclease activity	0.448568186952831	bayes_pls_golite062009
exodeoxyribonuclease activity, producing 5'-phosphomonoesters	0.436324225363531	bayes_pls_golite062009
single-stranded DNA specific exodeoxyribonuclease activity	0.285695976555125	bayes_pls_golite062009
protein binding	0.0455855311641946	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: