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View Structure Prediction Details

Protein: DRTS2_ARATH
Organism: Arabidopsis thaliana
Length: 565 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DRTS2_ARATH.

Description E-value Query
Range
Subject
Range
gi|7433454, gi|3... - pir||T14315 dihydrofolate reductase (EC 1.5.1.3) / thymidylate synthase (EC 2.1.1.45) - carrot, gi|...
755.0 [0..13] [565..20]

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Predicted Domain #1
Region A:
Residues: [1-565]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRCLQNSAKT LPLAFKSALL PLSQRWFCKF SPKPSSLTNI FKVSISTMAN TLNGNVIMTS  60
   61 KPQSTYQVVV AATKEMGIGK DGKLPWNLPT DLKFFKDLTL STSDSAKKNA VVMGRKTWES 120
  121 IPKKYRPLSG RLNVVLSRSS GFDIANTENV VTCSSIDSAL DLLAAPPFSL SIEKVFVIGG 180
  181 GDILREALNK PSCEAIHITE IDTSIDCDTF IPTVDTSAYQ PWCSSFPICE NGLRFSFTTH 240
  241 VRVKSSSAGE ASDESDGSKV LQVDWKKFSS VLPKMIFDRH EEYLYLNLVK EIISNGNLKD 300
  301 DRTGTGTLSK FGCQMKFNLR RNFPLLTTKR VFWRGVVEEL LWFISGSTNA KVLQEKGIRI 360
  361 WDGNASRAYL DGIGLTEREE GDLGPVYGFQ WRHFGAKYTD MHADYTGQGF DQLLDVINKI 420
  421 KNNPDDRRII MSAWNPSDLK LMALPPCHMF AQFYVANGEL SCQMYQRSAD MGLGVPFNIA 480
  481 SYSLLTCILA HVCDLVPGDF IHVIGDAHVY KNHVRPLQEQ LENPPKPFPV LKINPEKKDI 540
  541 DSFVADDFEL IGYDPHKKID MKMAV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 173.0
Match: 1qzfA
Description: Crystal structure of DHFR-TS from Cryptosporidium hominis
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
thymidylate synthase activity 6.6988475347328 bayes_pls_golite062009
5,10-methylenetetrahydrofolate-dependent methyltransferase activity 6.29181090719132 bayes_pls_golite062009
dihydrofolic acid binding 5.17709559620199 bayes_pls_golite062009
dihydrofolate reductase activity 4.66343252900911 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 4.14137539326183 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH group of donors 3.88025481634404 bayes_pls_golite062009
binding 1.89072001556053 bayes_pls_golite062009
catalytic activity 1.73427871128495 bayes_pls_golite062009
transferase activity 1.72626940963556 bayes_pls_golite062009
methyltransferase activity 0.927096828883487 bayes_pls_golite062009
transferase activity, transferring one-carbon groups 0.91282507161672 bayes_pls_golite062009
oxidoreductase activity 0.63757996555211 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle