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View Structure Prediction Details

Protein: gi|6729850, gi|6...
Organism: Escherichia coli
Length: 213 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|6729850, gi|6....

Description E-value Query
Range
Subject
Range
gi|1246364 - gi|1246364|gb|AAA93513.1| thymidylate:zeocin resistance protein:NDP kinase fusion protein [Cloning v...
188.0 [0..2] [213..3]
gi|1246361 - gi|1246361|gb|AAA93511.1| thymidine:thymidylate kinase:zeocin resistance fusion protein [Cloning vec...
186.0 [0..2] [213..217]
KTHY_ECOK1 - Thymidylate kinase OS=Escherichia coli O1:K1 / APEC GN=tmk PE=3 SV=1
gi|226898127, gi... - gi|237706917|ref|ZP_04537398.1| thymidylate kinase [Escherichia sp. 3_2_53FAA], gi|226898127|gb|EEH8...
KTHY_ECOUT - Thymidylate kinase OS=Escherichia coli (strain UTI89 / UPEC) GN=tmk PE=3 SV=1
KTHY_ECO45 - Thymidylate kinase OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=tmk PE=3 SV=1
184.0 [0..1] [213..1]
gi|227836750, gi... - gi|227886546|ref|ZP_04004351.1| thymidylate kinase [Escherichia coli 83972], gi|227836750|gb|EEJ4721...
KTHY_ECOL6 - Thymidylate kinase OS=Escherichia coli O6 GN=tmk PE=3 SV=1
KTHY_ECOL6 - Thymidylate kinase OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=tmk PE=3 SV=1
184.0 [0..1] [213..1]
gi|75235726, gi|... - gi|75235726|ref|ZP_00719896.1| COG0125: Thymidylate kinase [Escherichia coli F11], gi|191174621|ref|...
KTHY_ECO27 - Thymidylate kinase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=tmk PE=3 SV=1
KTHY_ECOL5 - Thymidylate kinase OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=tmk PE=3 SV=1
KTHY_ECOLU - Thymidylate kinase OS=Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC) GN=tmk PE=3 SV=1
sp|B7UPB4|KTHY_ECO27 - Thymidylate kinase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=tmk PE=3 SV=1
182.0 [0..1] [213..1]
gi|30040878, gi|... - gi|30062632|ref|NP_836803.1| thymidylate kinase [Shigella flexneri 2a str. 2457T], gi|30040878|gb|AA...
KTHY_ECODH - Thymidylate kinase OS=Escherichia coli (strain K12 / DH10B) GN=tmk PE=3 SV=1
EG12302 - thymidylate kinase / Thymidylate kinase
KTHY_ECOSE - Thymidylate kinase OS=Escherichia coli (strain SE11) GN=tmk PE=3 SV=1
KTHY_ECO8A - Thymidylate kinase OS=Escherichia coli O8 (strain IAI1) GN=tmk PE=3 SV=1
KTHY_ECO55 - Thymidylate kinase OS=Escherichia coli (strain 55989 / EAEC) GN=tmk PE=3 SV=1
gi|194433682, gi... - gi|83569580|ref|ZP_00921032.1| COG0125: Thymidylate kinase [Shigella dysenteriae 1012], gi|194433682...
gi|124532327, gi... - gi|124532327|ref|ZP_01702202.1| dTMP kinase [Escherichia coli B], gi|124498066|gb|EAY45596.1| dTMP k...
gi|1244710, gi|8... - gi|89107944|ref|AP_001724.1| thymidylate kinase [Escherichia coli str. K-12 substr. W3110], gi|40626...
KTHY_SHIF8 - Thymidylate kinase OS=Shigella flexneri serotype 5b (strain 8401) GN=tmk PE=3 SV=1
KTHY_SHIFL - Thymidylate kinase OS=Shigella flexneri GN=tmk PE=3 SV=1
gi|24112504, gi|... - gi|24112504|ref|NP_707014.1| thymidylate kinase [Shigella flexneri 2a str. 301], gi|24051393|gb|AAN4...
EG12302 - thymidylate kinase / Thymidylate kinase
gi|253973105, gi... - gi|254161204|ref|YP_003044312.1| thymidylate kinase [Escherichia coli B str. REL606], gi|253973105|g...
gi|253977319, gi... - gi|254288012|ref|YP_003053760.1| thymidylate kinase [Escherichia coli BL21(DE3)], gi|253977319|gb|AC...
gi|251784628, gi... - gi|251784628|ref|YP_002998932.1| hypothetical protein B21_01102 [Escherichia coli BL21], gi|24237690...
KTHY_ECOBW - Thymidylate kinase OS=Escherichia coli (strain K12 / MC4100 / BW2952) GN=tmk PE=3 SV=1
KTHY_ECOLC - Thymidylate kinase OS=Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks) GN=tmk PE=3 SV=1
KTHY_ECOLI - Thymidylate kinase (EC 2.7.4.9) (Thymidine monophosphate kinase) (dTMP kinase) (TMPK) - Escherichia ...
KTHY_ECOHS - Thymidylate kinase OS=Escherichia coli O9:H4 (strain HS) GN=tmk PE=3 SV=1
gi|75208975, gi|... - gi|75208975|ref|ZP_00709245.1| COG0125: Thymidylate kinase [Escherichia coli B171], gi|194429813|ref...
KTHY_SHIB3 - Thymidylate kinase OS=Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) GN=tmk PE=3 SV=1
KTHY_ECO24 - Thymidylate kinase OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=tmk PE=3 SV=1
KTHY_SHIDS - Thymidylate kinase OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=tmk PE=3 SV=1
KTHY_SHIBS - Thymidylate kinase OS=Shigella boydii serotype 4 (strain Sb227) GN=tmk PE=3 SV=1
gi|188495742, gi... - gi|75511413|ref|ZP_00734096.1| COG0125: Thymidylate kinase [Escherichia coli 53638], gi|188495742|re...
KTHY_SHISS - Thymidylate kinase OS=Shigella sonnei (strain Ss046) GN=tmk PE=3 SV=1
182.0 [0..1] [213..1]
KTHY_ECO57 - Thymidylate kinase OS=Escherichia coli O157:H7 GN=tmk PE=3 SV=1
gi|25288287, gi|... - pir||H85672 thymidylate kinase [imported] - Escherichia coli (strain O157:H7, substrain EDL933), pi...
gi|13360940, gi|... - gi|15830730|ref|NP_309503.1| thymidylate kinase [Escherichia coli O157:H7 str. Sakai], gi|13360940|d...
gi|217328521, gi... - gi|217328521|ref|ZP_03444603.1| thymidylate kinase [Escherichia coli O157:H7 str. TW14588], gi|21731...
gi|12514642, gi|... - gi|15801215|ref|NP_287232.1| thymidylate kinase [Escherichia coli O157:H7 EDL933], gi|12514642|gb|AA...
gi|254792480, gi... - gi|254792480|ref|YP_003077317.1| thymidylate kinase [Escherichia coli O157:H7 str. TW14359], gi|2545...
gi|208727593, gi... - gi|208807792|ref|ZP_03250129.1| thymidylate kinase [Escherichia coli O157:H7 str. EC4206], gi|208727...
gi|208732381, gi... - gi|208815733|ref|ZP_03256912.1| thymidylate kinase [Escherichia coli O157:H7 str. EC4045], gi|208732...
gi|208737885, gi... - gi|208822400|ref|ZP_03262719.1| thymidylate kinase [Escherichia coli O157:H7 str. EC4042], gi|208737...
KTHY_ECO5E - Thymidylate kinase OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=tmk PE=3 SV=1
gi|195938857 - gi|195938857|ref|ZP_03084239.1| thymidylate kinase [Escherichia coli O157:H7 str. EC4024]
181.0 [0..1] [213..1]
gi|89074515, gi|... - gi|89074515|ref|ZP_01160987.1| putative thymidylate kinase [Photobacterium sp. SKA34], gi|89049619|g...
180.0 [0..1] [210..1]
gi|84326490 - gi|84326490|ref|ZP_00974517.1| COG0125: Thymidylate kinase [Pseudomonas aeruginosa 2192]
180.0 [0..1] [208..1]
gi|90579079, gi|... - gi|90579079|ref|ZP_01234889.1| putative thymidylate kinase [Vibrio angustum S14], gi|90439912|gb|EAS...
179.0 [0..1] [209..1]

Back

Predicted Domain #1
Region A:
Residues: [1-213]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRSKYIVIEG LEGAGKTTAR NVVVETLEQL GIRDMVFTRE PGGTQLAEKL RSLLLDIKSV  60
   61 GDEVITDKAE VLMFYAARVQ LVETVIKPAL ANGTWVIGDR HDLSTQAYQG GGRGIDQHML 120
  121 ATLRDAVLGD FRPDLTLYLD VTPEVGLKRA RARGELDRIE QESFDFFNRT RARYLELAAQ 180
  181 DKSIHTIDAT QPLEAVMDAI RTTVTHWVKE LDA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 46.09691
Match: 4tmkA
Description: Thymidylate kinase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleobase, nucleoside, nucleotide kinase activity 3.31021342806183 bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism 3.01286198424677 bayes_pls_golite062009
nucleotide kinase activity 2.24094813695083 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 2.06460241490722 bayes_pls_golite062009
substrate-specific transporter activity 2.0114051513686 bayes_pls_golite062009
phosphotransferase activity, phosphate group as acceptor 1.96697952975573 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.92626167278464 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 1.9136419736217 bayes_pls_golite062009
ion transmembrane transporter activity 1.6854386921174 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 1.64467072658718 bayes_pls_golite062009
kinase activity 1.60827037072506 bayes_pls_golite062009
cation transmembrane transporter activity 1.5008821138859 bayes_pls_golite062009
binding 1.25659194713805 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
nucleotide binding 0.828524126097217 bayes_pls_golite062009
purine ribonucleotide binding 0.810407092593521 bayes_pls_golite062009
ribonucleotide binding 0.810379637652019 bayes_pls_golite062009
purine nucleotide binding 0.805605269661092 bayes_pls_golite062009
hydrolase activity 0.420858111948277 bayes_pls_golite062009
adenylate kinase activity 0.373057703057608 bayes_pls_golite062009
nucleic acid binding 0.216266069700019 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle