YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|157830999, gi...
Organism:	Homo sapiens
Length:	105 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|157830999, gi....

Description	E-value	Query Range	Subject Range
gi\|114626146 - gi\|114626146\|ref\|XP_001142154.1\| PREDICTED: similar to Thioredoxin (ATL-derived factor) (ADF) (Surfa...	148.0	[0..1]	[105..219]
gi\|76812139, gi\|... - gi\|76812139\|ref\|YP_333769.1\| thioredoxin 1 [Burkholderia pseudomallei 1710b], gi\|76581592\|gb\|ABA5106...	141.0	[0..2]	[105..43]
gi\|83721362, gi\|... - gi\|83721362\|ref\|YP_442739.1\| thioredoxin [Burkholderia thailandensis E264], gi\|83655187\|gb\|ABC39250....	139.0	[0..2]	[105..43]
gi\|53801490 - gi\|53801490\|gb\|AAU93947.1\| thioredoxin H [Helicosporidium sp. ex Simulium jonesii]	137.0	[0..2]	[104..5]
gi\|73971948 - gi\|73971948\|ref\|XP_532029.2\| PREDICTED: similar to Thioredoxin (ATL-derived factor) (ADF) (Surface a...	136.0	[0..11]	[105..125]
gi\|116057647 - gi\|116057647\|emb\|CAL53850.1\| Thioredoxin (ISS) [Ostreococcus tauri]	136.0	[0..1]	[105..112]
gi\|49076440, gi\|... - gi\|71020991\|ref\|XP_760726.1\| hypothetical protein UM04579.1 [Ustilago maydis 521], ref\|XP_402194.1\| ...	135.0	[0..1]	[104..1]
gi\|25067747 - gi\|25067747\|gb\|AAN65341.1\| thioredoxin/transketolase fusion protein [synthetic construct]	135.0	[0..2]	[105..5]
gi\|52006025, gi\|... - gi\|74316537\|ref\|YP_314277.1\| thioredoxin [Thiobacillus denitrificans ATCC 25259], gi\|74056032\|gb\|AAZ...	135.0	[0..4]	[105..7]
gi\|126097342, gi... - gi\|126208550\|ref\|YP_001053775.1\| thioredoxin [Actinobacillus pleuropneumoniae L20], gi\|126097342\|gb\|... gi\|32035159 - gi\|32035159\|ref\|ZP_00135199.1\| COG0526: Thiol-disulfide isomerase and thioredoxins [Actinobacillus p... gi\|165976501, gi... - gi\|165976501\|ref\|YP_001652094.1\| thioredoxin [Actinobacillus pleuropneumoniae serovar 3 str. JL03], ... gi\|190150405, gi... - gi\|190150405\|ref\|YP_001968930.1\| thioredoxin [Actinobacillus pleuropneumoniae serovar 7 str. AP76], ...	135.0	[0..1]	[105..1]

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Predicted Domain #1

Region A:
Residues: [1-105]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVKQIESKTA FQEALDAAGD KLVVVDFSAT WCGPCKMIKP FFHSLSEKYS NVIFLEVDVD  60
   61 DCQDVASECE VKSMPTFQFF KKGQKVGEFS GANKEKLEAT INELV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	32.522879
Match:	1ervA
Description:	HUMAN THIOREDOXIN MUTANT WITH CYS 73 REPLACED BY SER (REDUCED FORM)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
antioxidant activity	3.8464796631544	bayes_pls_golite062009
peroxidase activity	3.43831566988273	bayes_pls_golite062009
oxidoreductase activity, acting on peroxide as acceptor	3.43831566988273	bayes_pls_golite062009
glutathione peroxidase activity	2.56524997297011	bayes_pls_golite062009
protein disulfide isomerase activity	2.3913606099687	bayes_pls_golite062009
intramolecular oxidoreductase activity, transposing S-S bonds	2.3913606099687	bayes_pls_golite062009
protein-disulfide reductase activity	2.24066563461479	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	2.23310780102446	bayes_pls_golite062009
intramolecular oxidoreductase activity, interconverting keto- and enol-groups	2.18667085747706	bayes_pls_golite062009
peroxiredoxin activity	2.12777217096121	bayes_pls_golite062009
selenium binding	1.97148144306198	bayes_pls_golite062009
thioredoxin peroxidase activity	1.96134566495756	bayes_pls_golite062009
disulfide oxidoreductase activity	1.32811008894503	bayes_pls_golite062009
binding	1.25802922431343	bayes_pls_golite062009
transcription regulator activity	0.96297634785608	bayes_pls_golite062009
catalytic activity	0.672192331361968	bayes_pls_golite062009
hydrolase activity	0.620302638089385	bayes_pls_golite062009
protein disulfide oxidoreductase activity	0.44918717550973	bayes_pls_golite062009
glutathione binding	0.2456976890622	bayes_pls_golite062009
transferase activity	0.245320538630117	bayes_pls_golite062009
protein binding	0.134341907247724	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: