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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Ufd2. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 9 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
DSK2
  • nucleus
  • spindle pole body duplication in nuclear envelope
  • ER-associated protein catabolic process
  • protein binding, bridging
  • HMF1
  • nucleus
  • cytoplasm
  • cytosol
  • biological_process
  • molecular_function
  • NPL4
  • nuclear membrane-endoplasmic reticulum network
  • endoplasmic reticulum
  • ER-associated protein catabolic process
  • molecular_function
  • RAD23
  • nucleotide-excision repair factor 2 complex
  • mitochondrion
  • repairosome
  • proteasome complex
  • nucleotide-excision repair, DNA damage recognition
  • negative regulation of protein catabolic process
  • ER-associated protein catabolic process
  • damaged DNA binding
  • protein binding, bridging
  • SHP1
  • nucleus
  • cytoplasm
  • ascospore formation
  • proteasomal ubiquitin-dependent protein catabolic process
  • glycogen metabolic process
  • telomere maintenance
  • protein phosphatase type 1 regulator activity
  • TSL1
  • alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
  • trehalose biosynthetic process
  • response to stress
  • alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity
  • trehalose-phosphatase activity
  • enzyme regulator activity
  • UBI4
  • cytoplasm
  • protein deubiquitination
  • ascospore formation
  • protein polyubiquitination
  • protein monoubiquitination
  • response to stress
  • protein ubiquitination
  • protein tag
  • ATP-dependent protein binding
  • UFD2
  • nucleus
  • cytoplasm
  • ubiquitin cycle
  • response to stress
  • ubiquitin-dependent protein catabolic process
  • ubiquitin-protein ligase activity
  • YDR049W
  • cytoplasm
  • mitochondrion
  • biological_process
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleotide-excision repair factor 2 complex 2.859E-3 9 2 1 6292
    alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) 5.7106E-3 9 4 1 6292
    repairosome 5.7106E-3 9 4 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    modification-dependent protein catabolic process 1.0222E-6 9 156 5 6292
    ubiquitin-dependent protein catabolic process 1.0222E-6 9 156 5 6292
    proteolysis involved in cellular protein catabolic process 1.1239E-6 9 159 5 6292
    modification-dependent macromolecule catabolic process 1.3111E-6 9 164 5 6292
    proteasomal protein catabolic process 1.6017E-6 9 69 4 6292
    proteasomal ubiquitin-dependent protein catabolic process 1.6017E-6 9 69 4 6292
    cellular protein catabolic process 1.6138E-6 9 171 5 6292
    proteolysis 2.5823E-6 9 188 5 6292
    protein catabolic process 2.651E-6 9 189 5 6292
    cellular macromolecule catabolic process 1.3997E-5 9 265 5 6292
    ER-associated protein catabolic process 1.8029E-5 9 39 3 6292
    macromolecule catabolic process 2.3241E-5 9 294 5 6292
    cellular catabolic process 1.2303E-4 9 415 5 6292
    catabolic process 2.8786E-4 9 496 5 6292
    cellular protein metabolic process 1.283E-3 9 1074 6 6292
    protein metabolic process 1.7457E-3 9 1136 6 6292
    negative regulation of catabolic process 2.859E-3 9 2 1 6292
    negative regulation of protein catabolic process 2.859E-3 9 2 1 6292
    response to stress 3.515E-3 9 497 4 6292
    ubiquitin cycle 5.7106E-3 9 4 1 6292
    trehalose biosynthetic process 8.5551E-3 9 6 1 6292
    glycoside biosynthetic process 8.5551E-3 9 6 1 6292
    disaccharide biosynthetic process 8.5551E-3 9 6 1 6292
    nucleotide-excision repair, DNA damage recognition 9.9746E-3 9 7 1 6292
    regulation of protein catabolic process 9.9746E-3 9 7 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    protein binding, bridging 3.4102E-4 9 20 2 6292
    ATP-dependent protein binding 1.4304E-3 9 1 1 6292
    alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity 4.2857E-3 9 3 1 6292
    trehalose-phosphatase activity 4.2857E-3 9 3 1 6292
    carbohydrate phosphatase activity 9.9746E-3 9 7 1 6292

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