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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Ygl004c. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 16 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
RPN1
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • cytoplasm
  • endoplasmic reticulum
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • protein binding, bridging
  • RPN10
  • proteasome regulatory particle, base subcomplex
  • proteasome complex
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • RPN11
  • nucleus
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • RPN13
  • proteasome regulatory particle, lid subcomplex
  • proteolysis
  • endopeptidase activity
  • RPN14
  • cytoplasm
  • proteasome regulatory particle
  • proteolysis
  • ubiquitin-dependent protein catabolic process
  • molecular_function
  • RPN3
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • molecular_function
  • RPN5
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • molecular_function
  • RPN6
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • structural molecule activity
  • RPN7
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • structural molecule activity
  • RPN8
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • molecular_function
  • RPN9
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • structural molecule activity
  • RPT1
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • RPT2
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • RPT3
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • RPT4
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • RPT5
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    proteasome accessory complex 8.6643E-43 16 23 16 6292
    proteasome regulatory particle 8.6643E-43 16 23 16 6292
    proteasome complex 7.9691E-36 16 48 16 6292
    proteasome regulatory particle, lid subcomplex 9.5269E-21 16 10 8 6292
    proteasome regulatory particle, base subcomplex 5.3211E-18 16 9 7 6292
    protein complex 1.1852E-12 16 1137 16 6292
    macromolecular complex 4.0924E-10 16 1635 16 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    proteolysis 2.1332E-25 16 188 16 6292
    ubiquitin-dependent protein catabolic process 6.5366E-24 16 156 15 6292
    modification-dependent protein catabolic process 6.5366E-24 16 156 15 6292
    proteolysis involved in cellular protein catabolic process 8.8129E-24 16 159 15 6292
    modification-dependent macromolecule catabolic process 1.4315E-23 16 164 15 6292
    cellular protein catabolic process 2.7523E-23 16 171 15 6292
    protein catabolic process 1.3102E-22 16 189 15 6292
    cellular macromolecule catabolic process 2.4344E-20 16 265 15 6292
    macromolecule catabolic process 1.1983E-19 16 294 15 6292
    cellular catabolic process 2.3032E-17 16 415 15 6292
    catabolic process 3.4399E-16 16 496 15 6292
    protein metabolic process 1.1685E-12 16 1136 16 6292
    cellular protein metabolic process 3.7773E-11 16 1074 15 6292
    macromolecule metabolic process 1.379E-7 16 2349 16 6292
    cellular macromolecule metabolic process 2.5883E-6 16 2285 15 6292
    primary metabolic process 3.9666E-6 16 2896 16 6292
    metabolic process 1.5832E-5 16 3157 16 6292
    cellular metabolic process 1.5217E-4 16 3033 15 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    endopeptidase activity 1.373E-15 16 54 9 6292
    peptidase activity, acting on L-amino acid peptides 2.9102E-13 16 95 9 6292
    peptidase activity 1.8119E-10 16 192 9 6292
    hydrolase activity 1.1792E-4 16 911 9 6292
    ATPase activity 1.3059E-4 16 211 5 6292
    nucleoside-triphosphatase activity 1.0264E-3 16 329 5 6292
    hydrolase activity, acting on acid anhydrides 1.4107E-3 16 353 5 6292
    hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1.4107E-3 16 353 5 6292
    pyrophosphatase activity 1.4107E-3 16 353 5 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle