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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Rpn5. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 11 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
EMP24
  • integral to membrane
  • endoplasmic reticulum
  • ER to Golgi transport vesicle
  • ER to Golgi vesicle-mediated transport
  • vesicle organization
  • protein retention in ER lumen
  • molecular_function
  • KGD1
  • mitochondrial matrix
  • mitochondrial oxoglutarate dehydrogenase complex
  • mitochondrion
  • mitochondrial nucleoid
  • tricarboxylic acid cycle
  • 2-oxoglutarate metabolic process
  • oxoglutarate dehydrogenase (succinyl-transferring) activity
  • KRE6
  • integral to membrane
  • Golgi cis cisterna
  • cellular cell wall organization
  • 1,6-beta-glucan biosynthetic process
  • glucosidase activity
  • RPN1
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • cytoplasm
  • endoplasmic reticulum
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • protein binding, bridging
  • RPN12
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • RPN5
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • molecular_function
  • RPN6
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • structural molecule activity
  • RPN8
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • molecular_function
  • RPN9
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • structural molecule activity
  • RPT1
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • RPT2
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    proteasome regulatory particle 1.3254E-18 11 23 8 6292
    proteasome accessory complex 1.3254E-18 11 23 8 6292
    proteasome complex 1.0092E-15 11 48 8 6292
    proteasome regulatory particle, lid subcomplex 1.4133E-12 11 10 5 6292
    proteasome regulatory particle, base subcomplex 3.321E-7 11 9 3 6292
    protein complex 7.7426E-6 11 1137 9 6292
    macromolecular complex 1.7215E-4 11 1635 9 6292
    mitochondrial oxoglutarate dehydrogenase complex 5.2364E-3 11 3 1 6292
    oxoglutarate dehydrogenase complex 5.2364E-3 11 3 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    modification-dependent protein catabolic process 1.8506E-11 11 156 8 6292
    ubiquitin-dependent protein catabolic process 1.8506E-11 11 156 8 6292
    proteolysis involved in cellular protein catabolic process 2.16E-11 11 159 8 6292
    modification-dependent macromolecule catabolic process 2.7764E-11 11 164 8 6292
    cellular protein catabolic process 3.8951E-11 11 171 8 6292
    proteolysis 8.3794E-11 11 188 8 6292
    protein catabolic process 8.746E-11 11 189 8 6292
    cellular catabolic process 1.0622E-9 11 415 9 6292
    cellular macromolecule catabolic process 1.3198E-9 11 265 8 6292
    macromolecule catabolic process 3.0226E-9 11 294 8 6292
    catabolic process 5.2311E-9 11 496 9 6292
    cellular protein metabolic process 7.1339E-5 11 1074 8 6292
    protein metabolic process 1.0851E-4 11 1136 8 6292
    cellular macromolecule metabolic process 2.7237E-3 11 2285 9 6292
    macromolecule metabolic process 3.4003E-3 11 2349 9 6292
    2-oxoglutarate metabolic process 3.4937E-3 11 2 1 6292
    cellular metabolic process 4.1594E-3 11 3033 10 6292
    metabolic process 6.0149E-3 11 3157 10 6292
    1,6-beta-glucan biosynthetic process 6.9763E-3 11 4 1 6292
    1,6-beta-glucan metabolic process 8.7135E-3 11 5 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    endopeptidase activity 1.5298E-6 11 54 4 6292
    peptidase activity, acting on L-amino acid peptides 1.4843E-5 11 95 4 6292
    peptidase activity 2.3438E-4 11 192 4 6292
    oxoglutarate dehydrogenase (succinyl-transferring) activity 3.4937E-3 11 2 1 6292
    oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor 8.7135E-3 11 5 1 6292

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