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The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER. Any process by which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere. A process by which a protein is transported to, or maintained in, a location within the endoplasmic reticulum. Any process by which a protein is maintained in the endoplasmic reticulum and prevented from moving elsewhere. These include sequestration within the endoplasmic reticulum, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the endoplasmic reticulum.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: protein retention in ER lumen
Acc: GO:0006621
Aspect: Biological Process
Desc: The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER.
Synonyms:
  • maintenance of protein location in ER lumen
Proteins in PDR annotated with:
   This term: 42 [Search]
   Term or descendants: 42 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0006621 - protein retention in ER lumen (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle