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View Protein Complex Details

Complex Overview

From Publication: Krogan N. J. et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30;440(7084):637-43. Epub 2006 Mar 22.
Notes: From the published set of core protein complex predictions.
Complex Size: 17 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
AIM26
  • cellular_component
  • biological_process
  • molecular_function
  • APC9
  • anaphase-promoting complex
  • mitotic spindle elongation
  • cyclin catabolic process
  • mitotic sister chromatid segregation
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • mitotic metaphase/anaphase transition
  • protein ubiquitination
  • ubiquitin-protein ligase activity
  • protein binding
  • BEM3
  • intracellular
  • budding cell isotropic bud growth
  • small GTPase mediated signal transduction
  • pseudohyphal growth
  • invasive growth in response to glucose limitation
  • budding cell apical bud growth
  • Rho GTPase activator activity
  • phosphatidylinositol-3-phosphate binding
  • signal transducer activity
  • FMP27
  • mitochondrion
  • biological_process
  • molecular_function
  • IRA1
  • mitochondrion
  • membrane
  • negative regulation of Ras protein signal transduction
  • regulation of adenylate cyclase activity
  • negative regulation of cAMP biosynthetic process
  • positive regulation of Ras GTPase activity
  • Ras GTPase activator activity
  • MDM36
  • cellular_component
  • mitochondrion organization
  • molecular_function
  • MID1
  • endoplasmic reticulum
  • plasma membrane
  • calcium ion transport
  • stretch-activated, cation-selective, calcium channel activity
  • calcium channel activity
  • NUP42
  • nuclear pore
  • mRNA export from nucleus
  • rRNA export from nucleus
  • nuclear pore organization
  • snRNP protein import into nucleus
  • mRNA-binding (hnRNP) protein import into nucleus
  • snRNA export from nucleus
  • tRNA export from nucleus
  • NLS-bearing substrate import into nucleus
  • protein export from nucleus
  • ribosomal protein import into nucleus
  • structural molecule activity
  • REV1
  • nucleus
  • mitochondrion
  • mutagenesis
  • DNA repair
  • DNA-dependent DNA replication
  • DNA-directed DNA polymerase activity
  • deoxycytidyl transferase activity
  • SEC20
  • endoplasmic reticulum membrane
  • endoplasmic reticulum
  • retrograde vesicle-mediated transport, Golgi to ER
  • vesicle fusion
  • receptor signaling protein serine/threonine kinase activity
  • SML1
  • nucleus
  • cytoplasm
  • response to DNA damage stimulus
  • mitochondrion organization
  • enzyme inhibitor activity
  • TCO89
  • fungal-type vacuole membrane
  • extrinsic to vacuolar membrane
  • extrinsic to internal side of plasma membrane
  • TORC1 complex
  • glycerol metabolic process
  • fungal-type cell wall organization
  • response to salt stress
  • regulation of cell growth
  • molecular_function
  • TOP1
  • nucleus
  • nucleolus
  • mitotic chromosome condensation
  • chromatin silencing at rDNA
  • DNA strand elongation involved in DNA replication
  • nuclear migration
  • regulation of mitotic recombination
  • chromatin assembly or disassembly
  • DNA topological change
  • regulation of transcription from RNA polymerase II promoter
  • RNA elongation from RNA polymerase II promoter
  • DNA topoisomerase type I activity
  • YDR396W
    YGL024W
    ZAP1
  • nucleus
  • cellular zinc ion homeostasis
  • regulation of transcription from RNA polymerase II promoter
  • DNA binding
  • specific RNA polymerase II transcription factor activity
  • ZIM17
  • mitochondrial matrix
  • mitochondrion
  • protein import into mitochondrial matrix
  • protein folding
  • response to unfolded protein
  • mitochondrion organization
  • protein binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    extrinsic to vacuolar membrane 5.3968E-3 17 2 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    positive regulation of Ras GTPase activity 5.3968E-3 17 2 1 6292
    negative regulation of cAMP biosynthetic process 5.3968E-3 17 2 1 6292
    regulation of Ras GTPase activity 5.3968E-3 17 2 1 6292
    negative regulation of cAMP metabolic process 5.3968E-3 17 2 1 6292
    negative regulation of nucleotide biosynthetic process 5.3968E-3 17 2 1 6292
    negative regulation of cyclic nucleotide metabolic process 5.3968E-3 17 2 1 6292
    negative regulation of cyclic nucleotide biosynthetic process 5.3968E-3 17 2 1 6292
    positive regulation of GTPase activity 5.3968E-3 17 2 1 6292
    negative regulation of nucleotide metabolic process 5.3968E-3 17 2 1 6292
    mitochondrion organization 7.874E-3 17 156 3 6292
    regulation of cyclase activity 8.0849E-3 17 3 1 6292
    regulation of adenylate cyclase activity 8.0849E-3 17 3 1 6292
    regulation of lyase activity 8.0849E-3 17 3 1 6292
    positive regulation of hydrolase activity 8.0849E-3 17 3 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    Ras GTPase activator activity 1.2688E-3 17 20 2 6292
    mechanically-gated ion channel activity 2.7018E-3 17 1 1 6292
    stretch-activated, cation-selective, calcium channel activity 2.7018E-3 17 1 1 6292
    mechanically gated channel activity 2.7018E-3 17 1 1 6292
    deoxycytidyl transferase activity 2.7018E-3 17 1 1 6292
    GTPase activator activity 3.2496E-3 17 32 2 6292
    DNA topoisomerase type I activity 5.3968E-3 17 2 1 6292

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