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View Protein Complex Details

Complex Overview

From Publication: Mewes, H. W. et al. MIPS: Analysis and annotation of proteins from whole genomes. Nucleic Acids Res. 32, D41-D44
Notes: MIPS hand-curated complex set. MIPS complex ID: 510.40.20
Complex Size: 21 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CSE2
  • nucleus
  • mediator complex
  • mitotic sister chromatid segregation
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • DMC1
  • nucleus
  • condensed nuclear chromosome
  • meiotic joint molecule formation
  • reciprocal meiotic recombination
  • meiosis
  • double-stranded DNA binding
  • single-stranded DNA binding
  • GAL11
  • nucleus
  • mediator complex
  • telomere maintenance
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • MED11
  • mediator complex
  • transcription from RNA polymerase II promoter
  • structural molecule activity
  • RNA polymerase II transcription mediator activity
  • MED2
  • nucleus
  • mediator complex
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • MED4
  • nucleus
  • mediator complex
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • MED6
  • mediator complex
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • MED7
  • nucleus
  • mediator complex
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • MED8
  • mediator complex
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • NUT1
  • nucleus
  • mitochondrion
  • regulation of transcription from RNA polymerase II promoter
  • molecular_function
  • NUT2
  • nucleus
  • mediator complex
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • PGD1
  • nucleus
  • mediator complex
  • response to drug
  • telomere maintenance
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • RGR1
  • nucleus
  • mediator complex
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • ROX3
  • nucleus
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • SIN4
  • nucleus
  • mediator complex
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • SRB2
  • mediator complex
  • telomere maintenance
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • SRB4
  • mediator complex
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • SRB5
  • mediator complex
  • telomere maintenance
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • SRB6
  • mediator complex
  • transcription from RNA polymerase II promoter
  • structural molecule activity
  • RNA polymerase II transcription mediator activity
  • SRB7
  • nucleus
  • mediator complex
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • TAF14
  • SWI/SNF complex
  • transcription factor TFIID complex
  • Ino80 complex
  • transcription factor TFIIF complex
  • histone acetyltransferase complex
  • chromatin remodeling
  • regulation of transcription involved in G1 phase of mitotic cell cycle
  • transcription initiation from RNA polymerase II promoter
  • general RNA polymerase II transcription factor activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    mediator complex 1.0307E-45 21 18 17 6292
    nucleoplasm part 2.7407E-23 21 245 18 6292
    nucleoplasm 1.0923E-22 21 264 18 6292
    nuclear lumen 2.1324E-18 21 453 18 6292
    organelle lumen 1.8776E-15 21 660 18 6292
    intracellular organelle lumen 1.8776E-15 21 660 18 6292
    membrane-enclosed lumen 5.3789E-15 21 700 18 6292
    nuclear part 5.5277E-13 21 1103 19 6292
    protein complex 2.8849E-11 21 1137 18 6292
    nucleus 5.0329E-11 21 2041 21 6292
    macromolecular complex 1.5644E-8 21 1635 18 6292
    organelle part 3.6998E-7 21 2282 19 6292
    intracellular organelle part 3.6998E-7 21 2282 19 6292
    membrane-bounded organelle 2.0956E-5 21 3771 21 6292
    intracellular membrane-bounded organelle 2.0956E-5 21 3771 21 6292
    intracellular organelle 1.0447E-4 21 4070 21 6292
    organelle 1.0501E-4 21 4071 21 6292
    intracellular part 6.1098E-3 21 4938 21 6292
    intracellular 7.149E-3 21 4975 21 6292
    transcription factor TFIIF complex 9.9809E-3 21 3 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    transcription from RNA polymerase II promoter 3.8721E-25 21 335 20 6292
    transcription, DNA-dependent 1.5547E-21 21 503 20 6292
    RNA biosynthetic process 1.9005E-21 21 508 20 6292
    transcription 1.0245E-20 21 552 20 6292
    RNA metabolic process 6.2665E-16 21 954 20 6292
    nucleic acid metabolic process 2.1931E-14 21 1415 21 6292
    cellular macromolecule biosynthetic process 4.9429E-14 21 1187 20 6292
    macromolecule biosynthetic process 5.1116E-14 21 1189 20 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.871E-13 21 1566 21 6292
    gene expression 2.328E-13 21 1283 20 6292
    cellular nitrogen compound metabolic process 2.4869E-12 21 1770 21 6292
    nitrogen compound metabolic process 3.1903E-12 21 1791 21 6292
    cellular biosynthetic process 1.2353E-11 21 1567 20 6292
    biosynthetic process 1.9133E-11 21 1602 20 6292
    cellular macromolecule metabolic process 5.4516E-10 21 2285 21 6292
    macromolecule metabolic process 9.7623E-10 21 2349 21 6292
    primary metabolic process 8.0566E-8 21 2896 21 6292
    cellular metabolic process 2.1337E-7 21 3033 21 6292
    metabolic process 4.9632E-7 21 3157 21 6292
    cellular process 6.1031E-4 21 4426 21 6292
    meiotic joint molecule formation 6.6645E-3 21 2 1 6292
    chromosome organization 7.8714E-3 21 555 6 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    RNA polymerase II transcription mediator activity 2.6668E-46 21 22 18 6292
    general RNA polymerase II transcription factor activity 1.5022E-37 21 64 19 6292
    RNA polymerase II transcription factor activity 5.0907E-31 21 130 19 6292
    transcription regulator activity 9.2157E-23 21 339 19 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle