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View Protein Complex Details

Complex Overview

From Publication: Mewes, H. W. et al. MIPS: Analysis and annotation of proteins from whole genomes. Nucleic Acids Res. 32, D41-D44
Notes: MIPS hand-curated complex set. MIPS complex ID: 420.60
Complex Size: 14 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
AIM45
  • mitochondrion
  • biological_process
  • electron carrier activity
  • ALD4
  • mitochondrion
  • mitochondrial nucleoid
  • ethanol metabolic process
  • aldehyde dehydrogenase (NAD) activity
  • CIR1
  • mitochondrion
  • biological_process
  • molecular_function
  • CIR2
  • mitochondrion
  • NAD catabolic process
  • oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor
  • CIT1
  • mitochondrial matrix
  • mitochondrion
  • glutamate biosynthetic process
  • citrate metabolic process
  • tricarboxylic acid cycle
  • citrate (Si)-synthase activity
  • CYB2
  • mitochondrial intermembrane space
  • mitochondrion
  • electron transport
  • L-lactate dehydrogenase (cytochrome) activity
  • DLD1
  • mitochondrion
  • mitochondrial inner membrane
  • carbohydrate metabolic process
  • aerobic respiration
  • D-lactate dehydrogenase (cytochrome) activity
  • FUM1
  • mitochondrial matrix
  • mitochondrion
  • cytosol
  • tricarboxylic acid cycle
  • fumarate metabolic process
  • fumarate hydratase activity
  • GUT2
  • integral to mitochondrial outer membrane
  • mitochondrion
  • carbohydrate metabolic process
  • NADH oxidation
  • glycerol-3-phosphate dehydrogenase activity
  • MDH1
  • mitochondrial matrix
  • mitochondrion
  • malate metabolic process
  • tricarboxylic acid cycle
  • L-malate dehydrogenase activity
  • NDE1
  • mitochondrion
  • NADH oxidation
  • glucose catabolic process to ethanol
  • chronological cell aging
  • NADH dehydrogenase activity
  • NDE2
  • mitochondrion
  • NADH oxidation
  • glucose catabolic process to ethanol
  • NADH dehydrogenase activity
  • NDI1
  • mitochondrial matrix
  • mitochondrion
  • mitochondrial electron transport, NADH to ubiquinone
  • positive regulation of apoptosis
  • NADH oxidation
  • chronological cell aging
  • NADH dehydrogenase (ubiquinone) activity
  • SDH1
  • mitochondrial respiratory chain complex II
  • mitochondrion
  • tricarboxylic acid cycle
  • mitochondrial electron transport, succinate to ubiquinone
  • succinate dehydrogenase (ubiquinone) activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    mitochondrion 3.1923E-11 14 1125 14 6292
    mitochondrial part 1.0523E-7 14 475 9 6292
    cytoplasmic part 2.1603E-6 14 2482 14 6292
    mitochondrial matrix 2.6392E-5 14 176 5 6292
    mitochondrial lumen 2.6392E-5 14 176 5 6292
    cytoplasm 3.3016E-4 14 3552 14 6292
    membrane-bounded organelle 7.6409E-4 14 3771 14 6292
    intracellular membrane-bounded organelle 7.6409E-4 14 3771 14 6292
    intracellular organelle 2.2276E-3 14 4070 14 6292
    organelle 2.2353E-3 14 4071 14 6292
    membrane-enclosed lumen 2.5376E-3 14 700 6 6292
    mitochondrial envelope 3.9958E-3 14 312 4 6292
    mitochondrial respiratory chain complex II 8.8726E-3 14 4 1 6292
    succinate dehydrogenase complex (ubiquinone) 8.8726E-3 14 4 1 6292
    respiratory chain complex II 8.8726E-3 14 4 1 6292
    fumarate reductase complex 8.8726E-3 14 4 1 6292
    succinate dehydrogenase complex 8.8726E-3 14 4 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    coenzyme metabolic process 4.5625E-13 14 120 9 6292
    cofactor metabolic process 4.5032E-12 14 154 9 6292
    energy derivation by oxidation of organic compounds 2.1836E-10 14 149 8 6292
    coenzyme catabolic process 3.7158E-10 14 20 5 6292
    cofactor catabolic process 6.2964E-10 14 22 5 6292
    NAD metabolic process 1.2658E-9 14 25 5 6292
    generation of precursor metabolites and energy 1.89E-9 14 195 8 6292
    NADH oxidation 7.5177E-9 14 12 4 6292
    acetyl-CoA catabolic process 2.0652E-8 14 15 4 6292
    tricarboxylic acid cycle 2.0652E-8 14 15 4 6292
    NADH metabolic process 2.0652E-8 14 15 4 6292
    nicotinamide nucleotide metabolic process 2.2444E-8 14 43 5 6292
    cellular respiration 3.1236E-8 14 97 6 6292
    pyridine nucleotide metabolic process 3.1846E-8 14 46 5 6292
    acetyl-CoA metabolic process 7.2836E-8 14 20 4 6292
    oxidoreduction coenzyme metabolic process 1.1451E-7 14 59 5 6292
    aerobic respiration 6.4522E-7 14 83 5 6292
    monohydric alcohol metabolic process 1.4322E-6 14 11 3 6292
    ethanol metabolic process 1.4322E-6 14 11 3 6292
    nucleotide metabolic process 5.5689E-6 14 128 5 6292
    nucleoside phosphate metabolic process 5.5689E-6 14 128 5 6292
    small molecule metabolic process 5.956E-6 14 760 9 6292
    nucleobase, nucleoside and nucleotide metabolic process 1.5149E-5 14 157 5 6292
    catabolic process 3.8171E-5 14 496 7 6292
    glucose catabolic process to ethanol 9.5944E-5 14 7 2 6292
    glycolytic fermentation 1.2776E-4 14 8 2 6292
    chronological cell aging 4.1207E-4 14 14 2 6292
    fermentation 8.5383E-4 14 20 2 6292
    ATP synthesis coupled electron transport 1.3396E-3 14 25 2 6292
    mitochondrial ATP synthesis coupled electron transport 1.3396E-3 14 25 2 6292
    respiratory electron transport chain 1.3396E-3 14 25 2 6292
    electron transport chain 1.3396E-3 14 25 2 6292
    oxidation reduction 1.4494E-3 14 26 2 6292
    cellular catabolic process 1.4823E-3 14 415 5 6292
    dicarboxylic acid metabolic process 1.9301E-3 14 30 2 6292
    pyridine nucleotide catabolic process 2.225E-3 14 1 1 6292
    mitochondrial electron transport, NADH to ubiquinone 2.225E-3 14 1 1 6292
    NAD catabolic process 2.225E-3 14 1 1 6292
    organophosphate catabolic process 2.225E-3 14 1 1 6292
    fumarate metabolic process 2.225E-3 14 1 1 6292
    small molecule catabolic process 2.3739E-3 14 125 3 6292
    carbohydrate metabolic process 2.7315E-3 14 281 4 6292
    glucose catabolic process 4.1234E-3 14 44 2 6292
    vitamin catabolic process 4.4455E-3 14 2 1 6292
    water-soluble vitamin catabolic process 4.4455E-3 14 2 1 6292
    oxidative phosphorylation 4.4999E-3 14 46 2 6292
    hexose catabolic process 5.0935E-3 14 49 2 6292
    cell aging 5.0935E-3 14 49 2 6292
    aging 5.5083E-3 14 51 2 6292
    monosaccharide catabolic process 6.1587E-3 14 54 2 6292
    positive regulation of programmed cell death 6.6614E-3 14 3 1 6292
    positive regulation of cell death 6.6614E-3 14 3 1 6292
    positive regulation of apoptosis 6.6614E-3 14 3 1 6292
    alcohol catabolic process 6.8428E-3 14 57 2 6292
    regulation of programmed cell death 8.8726E-3 14 4 1 6292
    regulation of cell death 8.8726E-3 14 4 1 6292
    mitochondrial electron transport, succinate to ubiquinone 8.8726E-3 14 4 1 6292
    regulation of apoptosis 8.8726E-3 14 4 1 6292
    citrate metabolic process 8.8726E-3 14 4 1 6292
    malate metabolic process 8.8726E-3 14 4 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    oxidoreductase activity 2.3062E-11 14 281 10 6292
    NADH dehydrogenase activity 8.7719E-9 14 3 3 6292
    oxidoreductase activity, acting on NADH or NADPH 1.1394E-5 14 21 3 6292
    oxidoreductase activity, acting on CH-OH group of donors 2.3136E-5 14 81 4 6292
    lactate dehydrogenase activity 2.7517E-5 14 4 2 6292
    oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor 2.7517E-5 14 4 2 6292
    catalytic activity 1.0638E-4 14 2150 12 6292
    oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor 2.225E-3 14 1 1 6292
    L-lactate dehydrogenase (cytochrome) activity 2.225E-3 14 1 1 6292
    glycerol-3-phosphate dehydrogenase activity 2.225E-3 14 1 1 6292
    NADH dehydrogenase (quinone) activity 2.225E-3 14 1 1 6292
    NADH dehydrogenase (ubiquinone) activity 2.225E-3 14 1 1 6292
    fumarate hydratase activity 2.225E-3 14 1 1 6292
    aldehyde dehydrogenase (NAD) activity 2.225E-3 14 1 1 6292
    oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor 4.4455E-3 14 2 1 6292
    D-lactate dehydrogenase (cytochrome) activity 6.6614E-3 14 3 1 6292
    citrate (Si)-synthase activity 6.6614E-3 14 3 1 6292
    L-malate dehydrogenase activity 8.8726E-3 14 4 1 6292

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