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View Protein Complex Details

Complex Overview

From Publication: Mewes, H. W. et al. MIPS: Analysis and annotation of proteins from whole genomes. Nucleic Acids Res. 32, D41-D44
Notes: MIPS hand-curated complex set. MIPS complex ID: 420.40
Complex Size: 11 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
COX1
  • mitochondrion
  • mitochondrial respiratory chain complex IV
  • mitochondrial electron transport, cytochrome c to oxygen
  • aerobic respiration
  • cytochrome-c oxidase activity
  • COX12
  • mitochondrion
  • mitochondrial respiratory chain complex IV
  • respiratory chain complex IV assembly
  • cytochrome-c oxidase activity
  • COX13
  • mitochondrion
  • mitochondrial respiratory chain complex IV
  • aerobic respiration
  • cytochrome-c oxidase activity
  • enzyme regulator activity
  • COX2
  • mitochondrion
  • mitochondrial respiratory chain complex IV
  • mitochondrial electron transport, cytochrome c to oxygen
  • aerobic respiration
  • cytochrome-c oxidase activity
  • COX3
  • mitochondrion
  • mitochondrial respiratory chain complex IV
  • mitochondrial electron transport, cytochrome c to oxygen
  • aerobic respiration
  • cytochrome-c oxidase activity
  • COX4
  • mitochondrion
  • mitochondrial respiratory chain complex IV
  • mitochondrial electron transport, cytochrome c to oxygen
  • aerobic respiration
  • zinc ion binding
  • cytochrome-c oxidase activity
  • COX5A
  • mitochondrion
  • mitochondrial respiratory chain complex IV
  • mitochondrial electron transport, cytochrome c to oxygen
  • cytochrome-c oxidase activity
  • COX6
  • mitochondrion
  • mitochondrial respiratory chain complex IV
  • mitochondrial electron transport, cytochrome c to oxygen
  • cytochrome-c oxidase activity
  • COX7
  • mitochondrion
  • mitochondrial respiratory chain complex IV
  • mitochondrial electron transport, cytochrome c to oxygen
  • cytochrome-c oxidase activity
  • COX8
  • mitochondrion
  • mitochondrial respiratory chain complex IV
  • mitochondrial electron transport, cytochrome c to oxygen
  • cytochrome-c oxidase activity
  • COX9
  • mitochondrion
  • mitochondrial respiratory chain complex IV
  • mitochondrial electron transport, cytochrome c to oxygen
  • cytochrome-c oxidase activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    mitochondrial respiratory chain complex IV 7.897E-34 11 12 11 6292
    respiratory chain complex IV 7.897E-34 11 12 11 6292
    mitochondrial respiratory chain 5.0844E-28 11 26 11 6292
    respiratory chain 5.0844E-28 11 26 11 6292
    mitochondrial membrane part 9.3204E-21 11 100 11 6292
    mitochondrial inner membrane 5.2849E-18 11 174 11 6292
    organelle inner membrane 1.0577E-17 11 185 11 6292
    mitochondrial membrane 6.3069E-16 11 266 11 6292
    mitochondrial envelope 3.7618E-15 11 312 11 6292
    mitochondrial part 4.0747E-13 11 475 11 6292
    envelope 8.0482E-13 11 505 11 6292
    organelle envelope 8.0482E-13 11 505 11 6292
    membrane part 1.6229E-11 11 662 11 6292
    organelle membrane 2.6521E-11 11 692 11 6292
    mitochondrion 5.7346E-9 11 1125 11 6292
    protein complex 6.4478E-9 11 1137 11 6292
    membrane 1.1486E-8 11 1198 11 6292
    macromolecular complex 3.5578E-7 11 1635 11 6292
    organelle part 1.4064E-5 11 2282 11 6292
    intracellular organelle part 1.4064E-5 11 2282 11 6292
    cytoplasmic part 3.5506E-5 11 2482 11 6292
    cytoplasm 1.8433E-3 11 3552 11 6292
    membrane-bounded organelle 3.5629E-3 11 3771 11 6292
    intracellular membrane-bounded organelle 3.5629E-3 11 3771 11 6292
    intracellular organelle 8.2563E-3 11 4070 11 6292
    organelle 8.2787E-3 11 4071 11 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    mitochondrial electron transport, cytochrome c to oxygen 1.2983E-26 11 10 9 6292
    respiratory electron transport chain 2.6411E-21 11 25 9 6292
    electron transport chain 2.6411E-21 11 25 9 6292
    ATP synthesis coupled electron transport 2.6411E-21 11 25 9 6292
    mitochondrial ATP synthesis coupled electron transport 2.6411E-21 11 25 9 6292
    oxidation reduction 4.0382E-21 11 26 9 6292
    oxidative phosphorylation 1.4157E-18 11 46 9 6292
    cellular respiration 5.1337E-18 11 97 10 6292
    energy derivation by oxidation of organic compounds 4.4219E-16 11 149 10 6292
    generation of precursor metabolites and energy 6.9708E-15 11 195 10 6292
    phosphorylation 5.2391E-13 11 179 9 6292
    phosphorus metabolic process 4.9582E-12 11 229 9 6292
    phosphate metabolic process 4.9582E-12 11 229 9 6292
    aerobic respiration 1.5361E-7 11 83 5 6292
    cellular metabolic process 4.1594E-3 11 3033 10 6292
    metabolic process 6.0149E-3 11 3157 10 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    heme-copper terminal oxidase activity 7.897E-34 11 12 11 6292
    cytochrome-c oxidase activity 7.897E-34 11 12 11 6292
    oxidoreductase activity, acting on heme group of donors 7.897E-34 11 12 11 6292
    oxidoreductase activity, acting on heme group of donors, oxygen as acceptor 7.897E-34 11 12 11 6292
    hydrogen ion transmembrane transporter activity 6.2993E-24 11 54 11 6292
    monovalent inorganic cation transmembrane transporter activity 1.8418E-23 11 59 11 6292
    inorganic cation transmembrane transporter activity 1.046E-20 11 101 11 6292
    cation transmembrane transporter activity 6.2967E-20 11 118 11 6292
    ion transmembrane transporter activity 7.2E-19 11 146 11 6292
    substrate-specific transmembrane transporter activity 6.5779E-16 11 267 11 6292
    oxidoreductase activity 1.1663E-15 11 281 11 6292
    transmembrane transporter activity 3.0275E-15 11 306 11 6292
    substrate-specific transporter activity 8.6102E-15 11 336 11 6292
    transporter activity 6.7247E-14 11 404 11 6292
    catalytic activity 7.2915E-6 11 2150 11 6292

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