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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 21 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
POL4
  • nucleus
  • base-excision repair, gap-filling
  • double-strand break repair via nonhomologous end joining
  • double-strand break repair
  • DNA binding
  • DNA-directed DNA polymerase activity
  • nucleotidyltransferase activity
  • catalytic activity
  • metal ion binding
  • transferase activity
  • RPN1
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • cytoplasm
  • endoplasmic reticulum
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • protein binding, bridging
  • RPN10
  • proteasome regulatory particle, base subcomplex
  • proteasome complex
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • RPN11
  • nucleus
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • RPN12
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • RPN13
  • proteasome regulatory particle, lid subcomplex
  • proteolysis
  • endopeptidase activity
  • RPN2
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • protein binding, bridging
  • RPN5
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • molecular_function
  • RPN6
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • structural molecule activity
  • RPN8
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • molecular_function
  • RPN9
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • structural molecule activity
  • RPT1
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • RPT2
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • RPT4
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • RPT5
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • RPT6
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • SEM1
  • nucleus
  • microsome
  • cytosol
  • proteasome regulatory particle, lid subcomplex
  • filamentous growth
  • proteasomal ubiquitin-dependent protein catabolic process
  • telomere maintenance
  • exocytosis
  • ubiquitin-dependent protein catabolic process
  • molecular_function
  • SLX5
  • cellular_component
  • protein sumoylation
  • telomere maintenance
  • response to DNA damage stimulus
  • molecular_function
  • SPG5
  • cellular_component
  • biological_process
  • molecular_function
  • SWA2
  • endoplasmic reticulum membrane
  • telomere maintenance
  • endoplasmic reticulum organization
  • protein binding
  • UBP6
  • proteasome regulatory particle
  • protein deubiquitination
  • ubiquitin-specific protease activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    proteasome accessory complex 5.7629E-42 21 23 17 6292
    proteasome regulatory particle 5.7629E-42 21 23 17 6292
    proteasome complex 2.3868E-34 21 48 17 6292
    proteasome regulatory particle, base subcomplex 3.0139E-20 21 9 8 6292
    proteasome regulatory particle, lid subcomplex 1.5042E-19 21 10 8 6292
    protein complex 6.0581E-10 21 1137 17 6292
    macromolecular complex 2.0726E-7 21 1635 17 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    proteolysis 3.8092E-21 21 188 16 6292
    modification-dependent protein catabolic process 1.993E-20 21 156 15 6292
    ubiquitin-dependent protein catabolic process 1.993E-20 21 156 15 6292
    proteolysis involved in cellular protein catabolic process 2.681E-20 21 159 15 6292
    modification-dependent macromolecule catabolic process 4.3382E-20 21 164 15 6292
    cellular protein catabolic process 8.2964E-20 21 171 15 6292
    protein catabolic process 3.8954E-19 21 189 15 6292
    cellular macromolecule catabolic process 6.8259E-17 21 265 15 6292
    macromolecule catabolic process 3.2849E-16 21 294 15 6292
    cellular catabolic process 5.7411E-14 21 415 15 6292
    catabolic process 8.0377E-13 21 496 15 6292
    protein metabolic process 2.8408E-11 21 1136 18 6292
    cellular protein metabolic process 2.3882E-10 21 1074 17 6292
    macromolecule metabolic process 3.5684E-8 21 2349 20 6292
    cellular macromolecule metabolic process 3.7885E-7 21 2285 19 6292
    primary metabolic process 2.0783E-6 21 2896 20 6292
    metabolic process 1.0912E-5 21 3157 20 6292
    cellular metabolic process 5.7449E-5 21 3033 19 6292
    base-excision repair, gap-filling 6.6645E-3 21 2 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    endopeptidase activity 2.0862E-18 21 54 11 6292
    peptidase activity, acting on L-amino acid peptides 1.8086E-17 21 95 12 6292
    peptidase activity 1.071E-13 21 192 12 6292
    hydrolase activity 6.5753E-6 21 911 12 6292
    ATPase activity 5.3041E-4 21 211 5 6292
    protein binding, bridging 1.9443E-3 21 20 2 6292
    nucleoside-triphosphatase activity 3.8531E-3 21 329 5 6292
    hydrolase activity, acting on acid anhydrides 5.2116E-3 21 353 5 6292
    hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 5.2116E-3 21 353 5 6292
    pyrophosphatase activity 5.2116E-3 21 353 5 6292
    catalytic activity 8.5084E-3 21 2150 13 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle