YRC Public Data Repository - Protein Complex GO Analysis

Complex Overview

From Publication:	Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes:	Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size:	21 proteins

Complex Member Proteins

Protein	GO Cellular Component	GO Biological Process	GO Molecular Function
POL4	nucleus	base-excision repair, gap-filling double-strand break repair via nonhomologous end joining double-strand break repair	DNA binding DNA-directed DNA polymerase activity nucleotidyltransferase activity catalytic activity metal ion binding transferase activity
RPN1	nucleus proteasome regulatory particle, base subcomplex cytoplasm endoplasmic reticulum	ubiquitin-dependent protein catabolic process	endopeptidase activity protein binding, bridging
RPN10	proteasome regulatory particle, base subcomplex proteasome complex	ubiquitin-dependent protein catabolic process	endopeptidase activity
RPN11	nucleus proteasome regulatory particle, lid subcomplex	ubiquitin-dependent protein catabolic process	endopeptidase activity
RPN12	proteasome regulatory particle, lid subcomplex	ubiquitin-dependent protein catabolic process	endopeptidase activity
RPN13	proteasome regulatory particle, lid subcomplex	proteolysis	endopeptidase activity
RPN2	nucleus proteasome regulatory particle, base subcomplex	ubiquitin-dependent protein catabolic process	endopeptidase activity protein binding, bridging
RPN5	proteasome regulatory particle, lid subcomplex	ubiquitin-dependent protein catabolic process	molecular_function
RPN6	proteasome regulatory particle, lid subcomplex	ubiquitin-dependent protein catabolic process	structural molecule activity
RPN8	proteasome regulatory particle, lid subcomplex	ubiquitin-dependent protein catabolic process	molecular_function
RPN9	proteasome regulatory particle, lid subcomplex	ubiquitin-dependent protein catabolic process	structural molecule activity
RPT1	proteasome regulatory particle, base subcomplex	ubiquitin-dependent protein catabolic process	ATPase activity endopeptidase activity
RPT2	nucleus proteasome regulatory particle, base subcomplex	ubiquitin-dependent protein catabolic process	ATPase activity endopeptidase activity
RPT3	proteasome regulatory particle, base subcomplex	ubiquitin-dependent protein catabolic process	ATPase activity endopeptidase activity
RPT4	nucleus proteasome regulatory particle, base subcomplex	ubiquitin-dependent protein catabolic process	ATPase activity endopeptidase activity
RPT5	proteasome regulatory particle, base subcomplex	ubiquitin-dependent protein catabolic process	ATPase activity endopeptidase activity
RPT6	nucleus proteasome regulatory particle, base subcomplex	ubiquitin-dependent protein catabolic process	ATPase activity endopeptidase activity
SEM1	nucleus microsome cytosol proteasome regulatory particle, lid subcomplex	filamentous growth proteasomal ubiquitin-dependent protein catabolic process telomere maintenance exocytosis ubiquitin-dependent protein catabolic process	molecular_function
SLX5	cellular_component	protein sumoylation telomere maintenance response to DNA damage stimulus	molecular_function
SPG5	cellular_component	biological_process	molecular_function
UBP6	proteasome regulatory particle	protein deubiquitination	ubiquitin-specific protease activity

Cellular Component Analysis

Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
proteasome accessory complex	1.2262E-45	21	23	18	6292
proteasome regulatory particle	1.2262E-45	21	23	18	6292
proteasome complex	2.6336E-37	21	48	18	6292
proteasome regulatory particle, base subcomplex	6.9406E-24	21	9	9	6292
proteasome regulatory particle, lid subcomplex	1.5042E-19	21	10	8	6292
protein complex	2.8849E-11	21	1137	18	6292
macromolecular complex	1.5644E-8	21	1635	18	6292

Biological Process Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
proteolysis	3.1524E-23	21	188	17	6292
modification-dependent protein catabolic process	1.7155E-22	21	156	16	6292
ubiquitin-dependent protein catabolic process	1.7155E-22	21	156	16	6292
proteolysis involved in cellular protein catabolic process	2.3578E-22	21	159	16	6292
modification-dependent macromolecule catabolic process	3.9508E-22	21	164	16	6292
cellular protein catabolic process	7.9187E-22	21	171	16	6292
protein catabolic process	4.1582E-21	21	189	16	6292
cellular macromolecule catabolic process	1.059E-18	21	265	16	6292
macromolecule catabolic process	5.7127E-18	21	294	16	6292
cellular catabolic process	1.4583E-15	21	415	16	6292
catabolic process	2.4863E-14	21	496	16	6292
protein metabolic process	9.6066E-13	21	1136	19	6292
cellular protein metabolic process	1.0614E-11	21	1074	18	6292
macromolecule metabolic process	3.5684E-8	21	2349	20	6292
cellular macromolecule metabolic process	3.7885E-7	21	2285	19	6292
primary metabolic process	2.0783E-6	21	2896	20	6292
metabolic process	1.0912E-5	21	3157	20	6292
cellular metabolic process	5.7449E-5	21	3033	19	6292
base-excision repair, gap-filling	6.6645E-3	21	2	1	6292

Molecular Function Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
endopeptidase activity	1.1988E-20	21	54	12	6292
peptidase activity, acting on L-amino acid peptides	1.6763E-19	21	95	13	6292
peptidase activity	2.1827E-15	21	192	13	6292
hydrolase activity	7.4517E-7	21	911	13	6292
ATPase activity	4.713E-5	21	211	6	6292
nucleoside-triphosphatase activity	5.4257E-4	21	329	6	6292
hydrolase activity, acting on acid anhydrides	7.8937E-4	21	353	6	6292
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	7.8937E-4	21	353	6	6292
pyrophosphatase activity	7.8937E-4	21	353	6	6292
protein binding, bridging	1.9443E-3	21	20	2	6292
catalytic activity	2.3546E-3	21	2150	14	6292

View Protein Complex Details

Complex Overview

Complex Member Proteins

Cellular Component Analysis

Biological Process Analysis

Molecular Function Analysis