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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 20 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
GSG1
  • TRAPP complex
  • ER to Golgi vesicle-mediated transport
  • vesicle organization
  • autophagy
  • peroxisome degradation
  • meiosis
  • molecular_function
  • POL4
  • nucleus
  • base-excision repair, gap-filling
  • double-strand break repair via nonhomologous end joining
  • double-strand break repair
  • DNA binding
  • DNA-directed DNA polymerase activity
  • nucleotidyltransferase activity
  • catalytic activity
  • metal ion binding
  • transferase activity
  • RPN1
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • cytoplasm
  • endoplasmic reticulum
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • protein binding, bridging
  • RPN10
  • proteasome regulatory particle, base subcomplex
  • proteasome complex
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • RPN11
  • nucleus
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • RPN12
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • RPN13
  • proteasome regulatory particle, lid subcomplex
  • proteolysis
  • endopeptidase activity
  • RPN2
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • protein binding, bridging
  • RPN5
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • molecular_function
  • RPN6
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • structural molecule activity
  • RPN8
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • molecular_function
  • RPN9
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • structural molecule activity
  • RPT1
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • RPT2
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • RPT3
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • RPT4
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • RPT5
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • RPT6
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • SLX5
  • cellular_component
  • protein sumoylation
  • telomere maintenance
  • response to DNA damage stimulus
  • molecular_function
  • UBP6
  • proteasome regulatory particle
  • protein deubiquitination
  • ubiquitin-specific protease activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    proteasome accessory complex 1.0987E-42 20 23 17 6292
    proteasome regulatory particle 1.0987E-42 20 23 17 6292
    proteasome complex 4.5676E-35 20 48 17 6292
    proteasome regulatory particle, base subcomplex 3.966E-24 20 9 9 6292
    proteasome regulatory particle, lid subcomplex 1.1984E-16 20 10 7 6292
    protein complex 4.9584E-12 20 1137 18 6292
    macromolecular complex 2.9554E-9 20 1635 18 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    proteolysis 9.3096E-22 20 188 16 6292
    modification-dependent protein catabolic process 5.817E-21 20 156 15 6292
    ubiquitin-dependent protein catabolic process 5.817E-21 20 156 15 6292
    proteolysis involved in cellular protein catabolic process 7.8283E-21 20 159 15 6292
    modification-dependent macromolecule catabolic process 1.2677E-20 20 164 15 6292
    cellular protein catabolic process 2.427E-20 20 171 15 6292
    protein catabolic process 1.1427E-19 20 189 15 6292
    cellular macromolecule catabolic process 2.0259E-17 20 265 15 6292
    macromolecule catabolic process 9.7935E-17 20 294 15 6292
    cellular catabolic process 3.6931E-16 20 415 16 6292
    catabolic process 6.3788E-15 20 496 16 6292
    protein metabolic process 4.8817E-12 20 1136 18 6292
    cellular protein metabolic process 5.4081E-11 20 1074 17 6292
    macromolecule metabolic process 9.1608E-8 20 2349 19 6292
    cellular macromolecule metabolic process 9.5116E-7 20 2285 18 6292
    metabolic process 9.9232E-7 20 3157 20 6292
    primary metabolic process 4.3236E-6 20 2896 19 6292
    cellular metabolic process 1.0049E-5 20 3033 19 6292
    base-excision repair, gap-filling 6.3477E-3 20 2 1 6292
    cellular process 8.2259E-3 20 4426 19 6292
    peroxisome degradation 9.5071E-3 20 3 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    endopeptidase activity 5.1698E-21 20 54 12 6292
    peptidase activity, acting on L-amino acid peptides 6.4643E-20 20 95 13 6292
    peptidase activity 8.5411E-16 20 192 13 6292
    hydrolase activity 3.2711E-7 20 911 13 6292
    ATPase activity 3.4625E-5 20 211 6 6292
    nucleoside-triphosphatase activity 4.0518E-4 20 329 6 6292
    hydrolase activity, acting on acid anhydrides 5.9144E-4 20 353 6 6292
    hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 5.9144E-4 20 353 6 6292
    pyrophosphatase activity 5.9144E-4 20 353 6 6292
    catalytic activity 1.143E-3 20 2150 14 6292
    protein binding, bridging 1.7624E-3 20 20 2 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle