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Protein Overview: PAPOLA

General Information:
Name(s) found: PAPOLA [HGNC (HUGO)]
Description(s) found:
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  • gi|59803092|sp|P51003.4|PAPOA_HUMAN RecName: Full=Poly(A) polymerase alpha; Short=PAP-alpha; AltName: Full=Polynucleotide adenylyltransferase alpha [NCBI NR]
  • gi|32490557|ref|NP_116021.2| poly(A) polymerase alpha [Homo sapiens] [NCBI NR]
  • gi|23271194|gb|AAH36014.1| Poly(A) polymerase alpha [Homo sapiens] [NCBI NR]
  • gi|119602050|gb|EAW81644.1| poly(A) polymerase alpha, isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|119602048|gb|EAW81642.1| poly(A) polymerase alpha, isoform CRA_a [Homo sapiens] [NCBI NR]
  • poly(A) polymerase alpha [HGNC (HUGO)]
  • Poly(A) polymerase alpha OS=Homo sapiens GN=PAPOLA PE=1 SV=4 [Swiss-Prot]
  • poly(A) polymerase alpha [Homo sapiens]gi|23271194|gb|AAH36014.1| Poly(A) polymerase alpha [Homo sapiens] [nrdb_11152004_Chlamydomonas]
  • Poly(A) polymerase alpha (PAP) (Polynucleotide adenylyltransferase alpha) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 poly(A) polymerase alpha [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • poly(A) polymerase alpha [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • Tax_Id=9606 Poly(A) Polymerase alPha [EBI-IPI_human_3.12_11-03-2005_con_reversed.fasta]
  • Tax_Id=9606 Poly(A) Polymerase alPha [EBI-IPI_human_3.04_03-07-2005_reverse.fasta]
  • Poly(A) polymerase alpha (PAP-alpha) (Polynucleotide adenylyltransferase alpha) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • poly(A) polymerase alpha, isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Poly(A) polymerase alpha [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 Isoform 1 of Poly(A) polymerase alpha [IPI_human_3.26.fasta]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=PAPOLA Isoform 1 of Poly(A) polymerase alpha ENSG00000090060 IPI00384028 IPI00384154 [drosphohumanreversed.fasta]
  • Tax_Id=9606 Gene_Symbol=PAPOLA Isoform 1 of Poly(A) polymerase alpha [EBI-IPI_human_3.30_06-28-2007_con_reversed.fasta]
  • P51003;Q86SX4;Q86TV0;Q8IYF5;Q9BVU2; RecName: Full=Poly(A) polymerase alpha; AltName: Full=Polynucleotide adenylyltransferase alpha; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Isoform 1 of Poly(A) polymerase alpha OS=Homo sapiens GN=PAPOLA [011711_HMR.fasta]
  • GeneSymbol=PAPOLA Synonyms=MGC5378|PAP poly(A) polymerase alpha [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • Poly(A) polymerase alpha GN=PAPOLA [Doctor+uniprot-HUMAN-120911.fasta]
  • Poly(A) polymerase alpha, isoform CRA_a OS=Homo sapiens GN=PAPOLA PE=4 SV=1 [uniprot-human-031015-contam.fasta]
    • Organism: Homo sapiens
    Length: 745 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPFPVTTQGS QQTQPPQKHY GITSPISLAA PKETDCVLTQ KLIETLKPFG VFEEEEELQR  60
   61 RILILGKLNN LVKEWIREIS ESKNLPQSVI ENVGGKIFTF GSYRLGVHTK GADIDALCVA 120
  121 PRHVDRSDFF TSFYDKLKLQ EEVKDLRAVE EAFVPVIKLC FDGIEIDILF ARLALQTIPE 180
  181 DLDLRDDSLL KNLDIRCIRS LNGCRVTDEI LHLVPNIDNF RLTLRAIKLW AKRHNIYSNI 240
  241 LGFLGGVSWA MLVARTCQLY PNAIASTLVH KFFLVFSKWE WPNPVLLKQP EECNLNLPVW 300
  301 DPRVNPSDRY HLMPIITPAY PQQNSTYNVS VSTRMVMVEE FKQGLAITDE ILLSKAEWSK 360
  361 LFEAPNFFQK YKHYIVLLAS APTEKQRLEW VGLVESKIRI LVGSLEKNEF ITLAHVNPQS 420
  421 FPAPKENPDK EEFRTMWVIG LVFKKTENSE NLSVDLTYDI QSFTDTVYRQ AINSKMFEVD 480
  481 MKIAAMHVKR KQLHQLLPNH VLQKKKKHST EGVKLTALND SSLDLSMDSD NSMSVPSPTS 540
  541 ATKTSPLNSS GSSQGRNSPA PAVTAASVTN IQATEVSVPQ VNSSESSGGT SSESIPQTAT 600
  601 QPAISPPPKP TVSRVVSSTR LVNPPPRSSG NAATSGNAAT KIPTPIVGVK RTSSPHKEES 660
  661 PKKTKTEEDE TSEDANCLAL SGHDKTEAKE QLDTETSTTQ SETIQTAASL LASQKTSSTD 720
  721 LSDIPALPAN PIPVIKNSIK LRLNR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..500] PSI-BLAST 151.0 Poly(A) polymerase, middle domain; Poly(A) polymerase N-terminal, catalytic domain; Poly(A) polymerase, C-terminal domain
    2 View Details [501..645] FFAS03 1.54 No description for 2j63A was found.
    3 View Details [646..745] MSA 2.165995 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • RNA binding
    		•  2.46555984694381 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  1.61922062344227 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.43322212500405 bayes_pls_golite062009
  • polynucleotide adenylyltransferase activity
    		•  1.24026612395993 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.08480919674453 bayes_pls_golite062009
  • DNA binding
    		•  0.920001549206154 bayes_pls_golite062009
  • binding
    		•  0.888087430062829 bayes_pls_golite062009
  • catalytic activity
    		•  0.75232920999699 bayes_pls_golite062009
  • transferase activity
    		•  0.432029324907561 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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