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Protein Overview: ndc80

General Information:
Name(s) found: ndc80 / SPBC11C11.03 [Sanger Pombe]
Description(s) found:
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  • gi|3560194|emb|CAA20685.1| spindle pole body protein Ndc80 [Schizosaccharomyces pombe] [NCBI NR]
  • pir||S67382 hypothetical protein SPBC11C11.03 - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|19113184|ref|NP_596392.1| spindle pole body protein Ndc80 [Schizosaccharomyces pombe 972h-] [NCBI NR]
  • gi|1723267|sp|Q10198.1|NDC80_SCHPO RecName: Full=Kinetochore protein ndc80; AltName: Full=NMS complex subunit ndc80 [NCBI NR]
  • spindle pole body protein Ndc80 [Sanger Pombe]
  • (Q10198) Hypothetical protein C11C11.03 in chromosome II [Swiss-Prot]
  • Kinetochore protein ndc80 OS=Schizosaccharomyces pombe GN=ndc80 PE=1 SV=1 [Swiss-Prot]
  • CENTROMERE-ASSOCIATED SPINDLE COMPONENT; PUTATIVE SPINDLE POLE BODY; POSSIBLY INVOLVED IN CHROMOSOME SEGREGATION; PREDICTED COILED-COIL REGIONS; SIMILAR TO S. CEREVISIAE NDC80: Q10198; [pompepVF.fasta]
  • COILED COIL PROTEIN; PUTATIVE PROTEIN OF THE SPINDLE POLE BODY; BY SIMILARITY TO TID3: Q10198; [pompepV13]
  • Hypothetical protein C11C11.03 in chromosome II [pompep4896]
  • |ndc10|tid3|centromere component (GFP) (PMID 11266451) [pompepnew.fasta]
  • |ndc10|tid3|localization centromere (GFP) (PMID 11266451)|Schizosaccharomyces pombe|chr 2|||Manual [pombe041504.fasta]
  • |ndc80|ndc10, tid3|kinetochore protein Ndc80|Schizosaccharomyces pombe|chr 2|||Manual [pompep2242005.fasta]
  • coiled coil protein [Schizosaccharomyces pombe]gi|3560194|emb|CAA20685.1| SPBC11C11.03 [Schizosaccharomyces pombe]gi|1723267|sp|Q10198|YBY3_SCHPO Hypothetical protein C11C11.03 in chromosome IIgi|2130215|pir||S67382 hypothetical protein SPBC11C11.03 - [nrdb_11152004_Chlamydomonas]
  • |ndc80|ndc10, tid3|spindle pole body protein Ndc80|Schizosaccharomyces pombe|chr 2|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • SPBC11C11.03 [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • hypothetical protein SPBC11C11.03 [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • Kinetochore protein ndc80 [nr-271106-contam.fasta]
  • Kinetochore protein ndc80 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ndc80 PE=1 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 624 amino acids

    Gene Ontology:
    Cellular Component: Ndc80 complex [TASLink to PubMed article]
    NMS complex [IDALink to PubMed article]
    spindle pole body [IDALink to PubMed article]
    condensed nuclear chromosome kinetochore [IDALink to PubMed articleLink to PubMed article]
    Biological Process: attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation [IDALink to PubMed article]
    attachment of spindle microtubules to kinetochore [IDALink to PubMed article]
    chromosome segregation [ICLink to PubMed article]
    response to pheromone [IMPLink to PubMed article]
    Molecular Function: protein binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQDSSSYARR YSQAPSSSNL RTTTFGFNGL GTSRTSLAPQ RTLVNARQSI DPDGLSSRVL  60
   61 TPTMRPSLAP NTRRSSVRVS NASFISQTPN ITSIKDPRPL SDRRYQQECA TQVVNYLLES 120
  121 GFSQPLGLNN RFMPSTREFA AIFKHLYNKL DPNFRFGARY EEDVTTCLKA LNYPFLDSIS 180
  181 RSRLVAIGSP HVWPAILGML HWVVSLIQCT EKAVAMVYTV EQNSLDDHLV DKVLFDYLVR 240
  241 TYHLYLDESP EESEPEKELK ATFNQQNQDL YNQTEALKST NEELINQIKS AEELDSAIQV 300
  301 LEERYRTMQR DEVKFQSAMS GMKSKMESRT NLMKQLQVNI EEKESQLQLL KEKRDSLKYQ 360
  361 VENQDISISE FEKMVSEREQ LDRNLNMIGS KISELRKEVF DTDLLIQASI DSLEKKVQKF 420
  421 NSLAYRIGIV PIAAIRSANN DFELEINPEG PNYINLDLKN KVRPFINEVR RSITLEFHEE 480
  481 QNKSLKLQEH VDTVNDLIAE LQDELRGIES RLTSVLSECN MLRETASEEK NAFDAESDKL 540
  541 ERELQQLKLS SHNSMLQLDQ RIQSINIEAD QIAHACMEYK NNIYKEVAFV LGEIIHFKLH 600
  601 VQDSLEDLKM DYQKELDDLS RSEL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run nuf2 No Comments Liu X, et al. (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..388] PSI-BLAST 18.30103 Heavy meromyosin subfragment
    2 View Details [389..466] PSI-BLAST 10.30103 Tropomyosin
    3 View Details [467..624] PSI-BLAST 6.39794 No description for 2iw5A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  3.3573497204506 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • DNA binding
    		•  3.0205295442286 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.77547609431902 bayes_pls_golite062009
  • transcription factor activity
    		•  2.57014522504183 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.1457670954804 bayes_pls_golite062009
  • chromatin binding
    		•  1.68308196781423 bayes_pls_golite062009
  • actin binding
    		•  1.48871115327078 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.41102023549536 bayes_pls_golite062009
  • centromeric DNA binding
    		•  1.13545283098583 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.06075239560835 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.86319868225781 bayes_pls_golite062009
  • protein binding
    		•  0.830419844171551 bayes_pls_golite062009
  • transcription activator activity
    		•  0.68518521953823 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.526073636025138 bayes_pls_golite062009
  • transcription factor binding
    		•  0.45727836611098 bayes_pls_golite062009
  • telomeric DNA binding
    		•  0.284650049512347 bayes_pls_golite062009
  • actin filament binding
    		•  0.26311995282891 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.08523661344413 bayes_pls_golite062009
  • histone binding
    		•  0.0391625783266718 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.87

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle