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Protein Overview: his2

General Information:
Name(s) found: his2 / SPBC1711.13 [Sanger Pombe]
Description(s) found:
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  • gi|7630171|emb|CAB88243.1| histidinol dehydrogenase His2 (predicted) [Schizosaccharomyces pombe] [NCBI NR]
  • gi|29428033|sp|Q9P777.1|HISX_SCHPO RecName: Full=Histidinol dehydrogenase; Short=HDH [NCBI NR]
  • gi|19112678|ref|NP_595886.1| histidinol dehydrogenase His2 (predicted) [Schizosaccharomyces pombe 972h-] [NCBI NR]
  • histidinol dehydrogenase His2 [Sanger Pombe]
  • Histidinol dehydrogenase OS=Schizosaccharomyces pombe GN=his2 PE=2 SV=1 [Swiss-Prot]
  • PUTATIVE HISTIDINOL DEHYDROGENASE; SIMILAR TO S. CEREVISIAE HIS4: Q9P777; [pompepVF.fasta]
  • HISTIDINOL DEHYDROGENASE: Q9P777; [pompepV13]
  • Histidinol dehydrogenase (EC 1.1.1.23) (HDH) [pompep4896]
  • |his2||putative histidinol dehydrogenase [pompepnew.fasta]
  • |his2||histidinol dehydrogenase (predicted)|Schizosaccharomyces pombe|chr 2|||Manual [pombe041504.fasta]
  • histidinol dehydrogenase [Schizosaccharomyces pombe]gi|7630171|emb|CAB88243.1| his2 [Schizosaccharomyces pombe]gi|29428033|sp|Q9P777|HISX_SCHPO Histidinol dehydrogenase (HDH) [nrdb_11152004_Chlamydomonas]
  • |his2||histidinol dehydrogenase |Schizosaccharomyces pombe|chr 2|||Manual [pompep2242005.fasta]
  • (Q9P777) Histidinol dehydrogenase (EC 1.1.1.23) (HDH) [pompep4896_normal_reversed]
  • |his2||histidinol dehydrogenase His2 |Schizosaccharomyces pombe|chr 2|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • hypothetical protein SPBC1711.13 [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • SPBC1711.13 [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • Histidinol dehydrogenase (HDH) [nr-271106-contam.fasta]
  • Histidinol dehydrogenase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=his2 PE=3 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 439 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: histidine biosynthetic process [IMPLink to PubMed article]
    Molecular Function: zinc ion binding [IEA]
    NAD or NADH binding [IEA]
    histidinol dehydrogenase activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPEYEIQVPS YRAAALTAEE RTRLLARPIQ NTQKIRTIVQ PIIEDVKSRG EASLIDYASK  60
   61 FEKVQLKSAV LKAPFDDDLM KISPMIKEDI DIAFNNIFAF HSSQLRPTIA VQTMRGVVCQ 120
  121 RMSRPINRVG LYIPGGTAVL PSTALMLGVP AKVAGCPHVV ISTPVRKDGT VAPEIVYIAN 180
  181 KIGAEAIILA GGAQAIAAMA YGISGVPKVN KIFGPGNQFV TAAKMHVQND YGALVAIDLP 240
  241 AGPSEVLVIA DETCNPESVA LDLLSQAEHG LDSQIILLTV SLSPEMFDRI QKAINDHALR 300
  301 LSRSYIIKHA IKKSVIVQVD NVDQAFEWSN LYGPEHLVLH LKNASSYIPK IDNAGSVFVG 360
  361 PWSPVSMGDY ASGTNHTLPT YGYASSYSGV STDSFLKYIT TQELTEEGIQ RLGPTVIRLA 420
  421 ELEGLTAHAD AVRVRGVRL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..439] PSI-BLAST 170.0 L-histidinol dehydrogenase HisD

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • catalytic activity
    		•  2.80804701752928 bayes_pls_golite062009
  • histidinol dehydrogenase activity
    		•  2.32012109012499 bayes_pls_golite062009
  • oxidoreductase activity
    		•  2.31275077585879 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  2.24875477727877 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
    		•  2.22720948878196 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.50

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle