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Protein Overview: skap-PB, skap-PA

General Information:
Name(s) found: skap-PB / FBpp0112118 [FlyBase]
skap-PA / FBpp0081437 [FlyBase]
Description(s) found:
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  • gi|24645208|ref|NP_649846.2| CG11963, isoform A [Drosophila melanogaster] [NCBI NR]
  • gi|23170752|gb|AAF54308.2| CG11963, isoform A [Drosophila melanogaster] [NCBI NR]
  • gi|161078106|ref|NP_001097713.1| CG11963, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|158030193|gb|ABW08624.1| CG11963, isoform B [Drosophila melanogaster] [NCBI NR]
  • The gene skpA associated protein is referred to in FlyBase by the symbol Dmel\skap (CG11963, FBgn0037643). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:4764405..4768749. It has the cytological map location 85B7. Based on sequence similarity, it is predicted to have molecular function</span>: succinate-CoA ligase (ADP-forming) activity. There is experimental evidence that it is involved in the biological process</span>: regulation of centrosome duplication; mitotic spindle organization. 5 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
  • >CG11963-PA translation from_gene[CG11963 CG11963 FBgn0037643] seq_release:3 mol_weight=54808 cds_boundaries:(3R:4,764,557..4,768,568[+]) aa_length:502 transcript_info:[CG11963-RA seq_release:3] gene_info:[gene symbol:CG11963 FBgn0037643 gene_boundarie [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9VHJ8) CG11963-PA [DrosMelano7227.FASTAC.txt]
  • CG11963-PA [Drosophila melanogaster]gi|24645208|ref|NP_649846.2| CG11963-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3R:join(4764542..4764610,4765391..4765494,4766204..4766356,4766421..4766583,4766644..4766911,4767130..4767554,4767623..4767792,4768400..4768556); ID=FBpp0081437; name=CG11963-PA; parent=FBgn0037643,FBtr0081957; dbxref=FlyBase:FBpp0081437 [fly-100309-contam.fasta]
  • type=protein; loc=3R:join(4764542..4764610,4765391..4765494,4766204..4766356,4766421..4766583,4766644..4766911,4767130..4767554,4767623..4767792,4768400..4768556); ID=FBpp0112118; name=CG11963-PB; parent=FBgn0037643,FBtr0113206; dbxref=FlyBase:FBpp0112118 [fly-100309-contam.fasta]
  • CG11963-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=3R:join(4764542..4764610,4765391..4765494,4766204..4766356,4766421..4766583,4766644..4766911,4767130..4767554,4767623..4767792,4768400..4768556); ID=FBpp0081437; name=CG11963-PA; parent=FBgn0037643,FBtr0081957; dbxref=FlyBase:FBpp0081437,FlyBase_Annotation_IDs:CG11963-PA,GB_protein:AAF54308.2,REFSEQ:NP_649846,GB_protein:AAF54308; MD5=7e5ddbffee9e9084f399559b8dbcd651; length=502; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:join(4764542..4764610,4765391..4765494,4766204..4766356,4766421..4766583,4766644..4766911,4767130..4767554,4767623..4767792,4768400..4768556); ID=FBpp0112118; name=CG11963-PB; parent=FBgn0037643,FBtr0113206; dbxref=FlyBase:FBpp0112118,FlyBase_Annotation_IDs:CG11963-PB,REFSEQ:NP_001097713,GB_protein:ABW08624; MD5=7e5ddbffee9e9084f399559b8dbcd651; length=502; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:join(4764542..4764610,4765391..4765494,4766204..4766356,4766421..4766583,4766644..4766911,4767130..4767554,4767623..4767792,4768400..4768556); ID=FBpp0081437; name=skap-PA; parent=FBgn0037643,FBtr0081957; dbxref=FlyBase:FBpp0081437,FlyBase_Annotation_IDs:CG11963-PA,GB_protein:AAF54308.2,REFSEQ:NP_649846,GB_protein:AAF54308; MD5=7e5ddbffee9e9084f399559b8dbcd651; length=502; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=3R:join(4764542..4764610,4765391..4765494,4766204..4766356,4766421..4766583,4766644..4766911,4767130..4767554,4767623..4767792,4768400..4768556); ID=FBpp0112118; name=skap-PB; parent=FBgn0037643,FBtr0113206; dbxref=FlyBase:FBpp0112118,FlyBase_Annotation_IDs:CG11963-PB,REFSEQ:NP_001097713,GB_protein:ABW08624; MD5=7e5ddbffee9e9084f399559b8dbcd651; length=502; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • SkpA associated protein, isoform A OS=Drosophila melanogaster GN=skap PE=1 SV=2 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=3R:join(4764542..4764610,4765391..4765494,4766204..4766356,4766421..4766583,4766644..4766911,4767130..4767554,4767623..4767792,4768400..4768556); ID=FBpp0081437; name=skap-PA; parent=FBgn0037643,FBtr0081957; dbxref=FlyBase:FBpp0081437,FlyBase_Annotation_IDs:CG11963-PA,GB_protein:AAF54308.2,REFSEQ:NP_649846,GB_protein:AAF54308,FlyMine:FBpp0081437,modMine:FBpp0081437; MD5=7e5ddbffee9e9084f399559b8dbcd651; length=502; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=3R:join(4764542..4764610,4765391..4765494,4766204..4766356,4766421..4766583,4766644..4766911,4767130..4767554,4767623..4767792,4768400..4768556); ID=FBpp0112118; name=skap-PB; parent=FBgn0037643,FBtr0113206; dbxref=FlyBase:FBpp0112118,FlyBase_Annotation_IDs:CG11963-PB,REFSEQ:NP_001097713,GB_protein:ABW08624; MD5=7e5ddbffee9e9084f399559b8dbcd651; length=502; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • SkpA associated protein, isoform A OS=Drosophila melanogaster GN=skap PE=2 SV=2 [UniProt_D_Melanogaster_07132012_07-13-2012_reversed.fasta]
  • type=protein; loc=3R:join(8938820..8938888,8939669..8939772,8940482..8940634,8940699..8940861,8940922..8941189,8941408..8941832,8941901..8942070,8942678..8942834); ID=FBpp0081437; name=skap-PA; parent=FBgn0037643,FBtr0081957; dbxref=FlyBase:FBpp0081437,FlyBase_Annotation_IDs:CG11963-PA,GB_protein:AAF54308.2,REFSEQ:NP_649846,GB_protein:AAF54308,FlyMine:FBpp0081437,modMine:FBpp0081437; MD5=7e5ddbffee9e9084f399559b8dbcd651; length=502; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:join(8938820..8938888,8939669..8939772,8940482..8940634,8940699..8940861,8940922..8941189,8941408..8941832,8941901..8942070,8942678..8942834); ID=FBpp0112118; name=skap-PB; parent=FBgn0037643,FBtr0113206; dbxref=FlyBase:FBpp0112118,FlyBase_Annotation_IDs:CG11963-PB,REFSEQ:NP_001097713,GB_protein:ABW08624; MD5=7e5ddbffee9e9084f399559b8dbcd651; length=502; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:join(8938820..8938888,8939669..8939772,8940482..8940634,8940699..8940861,8940922..8941189,8941408..8941832,8941901..8942070,8942678..8942834); ID=FBpp0081437; name=skap-PA; parent=FBgn0037643,FBtr0081957; dbxref=FlyBase:FBpp0081437,FlyBase_Annotation_IDs:CG11963-PA,GB_protein:AAF54308.2,REFSEQ:NP_649846,GB_protein:AAF54308,FlyMine:FBpp0081437,modMine:FBpp0081437; MD5=7e5ddbffee9e9084f399559b8dbcd651; length=502; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • type=protein; loc=3R:join(8938820..8938888,8939669..8939772,8940482..8940634,8940699..8940861,8940922..8941189,8941408..8941832,8941901..8942070,8942678..8942834); ID=FBpp0112118; name=skap-PB; parent=FBgn0037643,FBtr0113206; dbxref=FlyBase:FBpp0112118,FlyBase_Annotation_IDs:CG11963-PB,REFSEQ:NP_001097713,GB_protein:ABW08624; MD5=7e5ddbffee9e9084f399559b8dbcd651; length=502; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Isoform of Q95U38, Succinyl-CoA ligase subunit beta OS=Drosophila melanogaster GN=skap PE=1 SV=2 [DROME.fasta.20160308]
  • FBpp0081437 type=protein; loc=3R:join(8938820..8938888,8939669..8939772,8940482..8940634,8940699..8940861,8940922..8941189,8941408..8941832,8941901..8942070,8942678..8942834); ID=FBpp0081437; name=skap-PA; parent=FBgn0037643,FBtr0081957; dbxref=FlyBase:FBpp0081437,FlyBase_Annotation_IDs:CG11963-PA,GB_protein:AAF54308.2,REFSEQ:NP_649846,GB_protein:AAF54308,FlyMine:FBpp0081437,modMine:FBpp0081437; MD5=7e5ddbffee9e9084f399559b8dbcd651; length=502; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • FBpp0112118 type=protein; loc=3R:join(8938820..8938888,8939669..8939772,8940482..8940634,8940699..8940861,8940922..8941189,8941408..8941832,8941901..8942070,8942678..8942834); ID=FBpp0112118; name=skap-PB; parent=FBgn0037643,FBtr0113206; dbxref=FlyBase:FBpp0112118,FlyBase_Annotation_IDs:CG11963-PB,REFSEQ:NP_001097713,GB_protein:ABW08624; MD5=7e5ddbffee9e9084f399559b8dbcd651; length=502; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3R:join(8938820..8938888,8939669..8939772,8940482..8940634,8940699..8940861,8940922..8941189,8941408..8941832,8941901..8942070,8942678..8942834); ID=FBpp0081437; name=skap-PA; parent=FBgn0037643,FBtr0081957; dbxref=FlyBase:FBpp0081437,FlyBase_Annotation_IDs:CG11963-PA,GB_protein:AAF54308.2,REFSEQ:NP_649846,GB_protein:AAF54308,UniProt/TrEMBL:Q9VHJ8,FlyMine:FBpp0081437,modMine:FBpp0081437; MD5=7e5ddbffee9e9084f399559b8dbcd651; length=502; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
  • type=protein; loc=3R:join(8938820..8938888,8939669..8939772,8940482..8940634,8940699..8940861,8940922..8941189,8941408..8941832,8941901..8942070,8942678..8942834); ID=FBpp0112118; name=skap-PB; parent=FBgn0037643,FBtr0113206; dbxref=FlyBase:FBpp0112118,FlyBase_Annotation_IDs:CG11963-PB,REFSEQ:NP_001097713,GB_protein:ABW08624,UniProt/TrEMBL:Q9VHJ8; MD5=7e5ddbffee9e9084f399559b8dbcd651; length=502; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 502 amino acids

    Gene Ontology:
    Cellular Component: succinate-CoA ligase complex (ADP-forming) [ISS]
    centrosome [IDA]
    Biological Process: regulation of centrosome duplication [IMP]
    mitotic spindle organization [IMP]
    tricarboxylic acid cycle [ISS]
    Molecular Function: ATP binding [IEA]
    succinate-CoA ligase (ADP-forming) activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASFLARTGG PLIETVRPAA IKKILGLAPI AVQQLRNLNV QEHVSYSLLN EAKIPTPRFA  60
   61 VAKNGKEAND IATKLKTDNL VLKAQVLAGG RGKGTFKNGL KGGVRVVYDP QTAEELSSKM 120
  121 IDQLLVTKQT GAAGRICKKV MVAERKFPRR EFYFAVMMER AFNGPVLIAS KEGGVDIEEV 180
  181 AASSPDAILY EPIDIGTGLT SEQAEKIVKK VGLGGDGEDT HVQMLLNLYD LFVKKDALLV 240
  241 EINPYAEDAM SGFFALDAKL RFDDNAEFRQ KELFALRDWT QEDPKEVEAA KYNLNYIALD 300
  301 GTIGCMVNGA GLAMATMDII KLYGGEPANF LDVGGGATAE AVKAAFKIIT SDPKVLCILV 360
  361 NIFGGIMRCD VIAEGIISAT KDLNLNMPVV VRLQGTKVKE ARELIRTSGL KILARDDLDK 420
  421 AADLAVHLAQ IVKLAREMKM DVNFEIPDAQ KGKGDCKKDQ KQPDSKGGKK SEKKDDKKSD 480
  481 CTKKEEKKKE EKKDICEKKG KK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..502] PSI-BLAST 93.0 Crystal structure of pig GTP-specific succinyl-CoA synthetase in complex with GTP

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • succinate-CoA ligase activity
    		•  11.5979130191209 bayes_pls_golite062009
  • succinate-CoA ligase (GDP-forming) activity
    		•  10.9659410855563 bayes_pls_golite062009
  • CoA-ligase activity
    		•  10.4192804448897 bayes_pls_golite062009
  • acid-thiol ligase activity
    		•  10.243481928473 bayes_pls_golite062009
  • ligase activity, forming carbon-sulfur bonds
    		•  9.48706872092269 bayes_pls_golite062009
  • succinate-CoA ligase (ADP-forming) activity
    		•  9.35325976720833 bayes_pls_golite062009
  • ATP citrate synthase activity
    		•  3.09252003125984 bayes_pls_golite062009
  • transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
    		•  3.07329302783164 bayes_pls_golite062009
  • ligase activity
    		•  2.30626698552338 bayes_pls_golite062009
  • catalytic activity
    		•  1.90735517755117 bayes_pls_golite062009
  • CoA carboxylase activity
    		•  1.75094739650292 bayes_pls_golite062009
  • ligase activity, forming carbon-carbon bonds
    		•  1.59015373957506 bayes_pls_golite062009
  • acetyl-CoA carboxylase activity
    		•  1.29064883699349 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  1.15639517822408 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  0.992008268375695 bayes_pls_golite062009
  • binding
    		•  0.86195116772024 bayes_pls_golite062009
  • protein binding
    		•  0.314199580917925 bayes_pls_golite062009
  • biotin carboxylase activity
    		•  0.0172732430077291 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle