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Protein Overview: NPR2

General Information:
Name(s) found: NPR2 / YEL062W [SGD]
Description(s) found:
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  • gi|84028230|sp|P39923.2|NPR2_YEAST RecName: Full=Nitrogen permease regulator 2 [NCBI NR]
  • gi|37362640|ref|NP_010852.2| Protein with a possible role in regulating expression of nitrogen permeases; transcription is induced in response to proline and urea; contains two PEST sequences; null mutant is resistant to cisplatin and doxorubicin; Npr2p [ [NCBI NR]
  • Nitrogen permease regulator 2 OS=Saccharomyces cerevisiae GN=NPR2 PE=1 SV=2 [Swiss-Prot]
  • NPR2 Nitrogen permease regulator [mips]
  • Component of an evolutionarily conserved Npr2/3 complex that mediates downregulation of TORC1 activity in response to amino acid limitation; homolog of human NPRL2; target of Grr1p (E3 ligase); required for growth on urea and proline [SGD]
  • Chr V from 34407-36254 [yeastorf5.fasta]
  • NPR2 SGDID:S0000788, Chr V from 34407-36254, Verified ORF [yeastflysequest.fasta]
  • Npr2p [Saccharomyces cerevisiae] [nrdb_11152004_Chlamydomonas]
  • NPR2 SGDID:S000000788, Chr V from 34407-36254, Verified ORF, "Regulator of nitrogen permeases; transcription is induced in response to proline and urea; contains two PEST sequences" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • NPR2 SGDID:S000000788, Chr V from 34407-36254, Verified ORF, "Protein with a possible role in regulating expression of nitrogen permeases; transcription is induced in response to proline and urea; contains two PEST sequences; null mutant is resistant to c [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • Nitrogen permease regulator 2 [nr-271106-contam.fasta]
  • Regulator of nitrogen permeases; transcription is induced in response to proline and urea; contains two PEST sequences; Npr2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • NPR2 SGDID:S000000788, Chr V from 34407-36254, Verified ORF, "Component, with Npr3p, of an evolutionarily conserved complex that mediates downregulation of TOR Complex 1 activity in response to amino acid limitation; transcription is induced in response t [SGD_S-cerevisiae_na_01-05-2010_reversed.fasta]
  • NPR2 SGDID:S000000788, Chr V from 34407-36254, Verified ORF, "Protein with a possible role in regulating expression of nitrogen permeases; transcription is induced in response to proline and urea; contains two PEST sequences; null mutant is resistant to cisplatin and doxorubicin" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • NPR2 SGDID:S000000788, Chr V from 34407-36254, Verified ORF, "Component, with Npr3p, of an evolutionarily conserved complex that mediates downregulation of TOR Complex 1 activity in response to amino acid limitation; transcription is induced in response to proline and urea" [SGDyeast.20101221.fasta]
  • Nitrogen permease regulator 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NPR2 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • NPR2 SGDID:S000000788, Chr V from 34407-36254, Genome Release 64-1-1, Verified ORF, "Subunit of the conserved Npr2/3 complex that mediates downregulation of TORC1 activity upon amino acid limitation; subunit of SEA (Seh1-associated) complex; homolog of human NPRL2; target of Grr1p; required for growth on urea and proline" [yeast-030211-contam.fasta]
  • NPR2 SGDID:S000000788, Chr V from 34407-36254, Genome Release 64-2-1, Verified ORF, "Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex is required for non-nitrogen-starvation (NNS)-induced autophagy; Iml1p interacts primarily with phosphorylated Npr2p; homolog of human tumor suppressor NPRL2; target of Grr1p; required for growth on urea and proline" [20141208_orf_trans.fasta]
  • YEL062W SGDID:S000000788, Chr V from 34407-36254, Genome Release 64-1-1, Verified ORF, "Subunit of the conserved Npr2/3 complex that mediates downregulation of TORC1 activity upon amino acid limitation; subunit of SEA (Seh1-associated) complex; homolog of human NPRL2; target of Grr1p; required for growth on urea and proline" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 615 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: urea transport [IMPLink to PubMed article]
    response to drug [IMPLink to PubMed article]
    proline transport [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSYFQGFVP IHTIFYSVFH PTEGSKIKYE FPPNNLKNHG INFNTFKNYI IPKPILCHKL  60
   61 ITFKYGTYRI VCYPVTINSP IYARNFFSFN FVFVFPYDCE TSPYEPAITR LGKMFKVLEE 120
  121 QNQLLSKSER DPVFFDLKVL ENSTTTPSTA GPSSTPNPSS NTTPTHPTSE KDTKDMRSSR 180
  181 YSDLIKDLGL PQSAFSIQDL LMRIFQDLNN YSECLIPIDE GNAVDIKIFP LLRPPTTCVS 240
  241 LEDVPLSSVN LKKIIDVNWD PTMMSIVPYI DGLNSIAKIS KLSNSDPGLV IECIRHLIYY 300
  301 KCVTLSDIFQ FSNIYAPSSL IRNFLTDPLM ASDCQSYVTF PEVSKISNLP LNKSLGSGDQ 360
  361 DSPSFSVRRK SKSSSIPSNP DSRTTSFSST SRVSQNSSLN SSFSSIYKDW RQSQTSCSSS 420
  421 NIHVINNRNR FLPTRSCLFD LYRSLSQGQT LKTWYESKYM ILKENNIDIR RFITFGLEKR 480
  481 IIYRCYSFPV MINAGSREPK EMTPIITKDL VNNDKLLEKR NHNHLLSATG SRNTAQSGNL 540
  541 KPERPSKVSF EMQRVSSLAT GKSTMPKLSD EEEGILEESI RNAETFDKIC VLLSKPKLEV 600
  601 ESYLNELGEF KVINS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BOS1 NPR2
    View Details Ho Y, et al. (2002) CCT6 CDC33 CPR6 FMP10 MDJ1 MTC5 NPR2 POX1 RNQ1 SEH1 THI21 YHR033W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data NPR2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..78] deduced N/A No confident structure predictions are available.
    2 View Details [79..174] MSA 2.02899 View MSA. No confident structure predictions are available.
    3 View Details [175..342] MSA 1.029987 View MSA. No confident structure predictions are available.
    4 View Details [343..426] deduced N/A No confident structure predictions are available.
    5 View Details [427..521] deduced N/A No confident structure predictions are available.
    6 View Details [522..615] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle