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Protein Overview: HRK1

General Information:
Name(s) found: HRK1 / YOR267C [SGD]
Description(s) found:
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  • gi|6324841|ref|NP_014910.1| Protein kinase implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis; Hrk1p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|59799591|sp|Q08732.1|HRK1_YEAST RecName: Full=Serine/threonine-protein kinase HRK1; AltName: Full=Hygromycin resistance kinase 1 [NCBI NR]
  • pir||S67164 probable membrane protein YOR267c - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1420600|emb|CAA99490.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • Serine/threonine-protein kinase HRK1 OS=Saccharomyces cerevisiae GN=HRK1 PE=1 SV=1 [Swiss-Prot]
  • HRK1 Protein kinase with a role in ion homeostasis [mips]
  • Protein kinase implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis [SGD]
  • >Q08732 (Q08732) Chromosome XV reading frame ORF YOR267C [4932.FASTACCERV.txt]
  • Chr XV from 824864-822585, reverse complement [hmr_yeast5_DM3-1_pombe.fasta]
  • Chr XV from 822584-824863, reverse complement [yeastorf3.fasta]
  • Chr XV from 822585-824864, reverse complement [yeastorf4.fasta]
  • YOR267C, Chr XV from 822584-824863, reverse complement [yeast_orfs2]
  • HRK1 SGDID:S0005793, Chr XV from 824864-822585, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Hrk1p [Saccharomyces cerevisiae]gi|1420600|emb|CAA99490.1| unnamed protein product [Saccharomyces cerevisiae]gi|2132931|pir||S67164 probable membrane protein YOR267c - yeast (Saccharomyces cerevisiae) [nrdb_11152004_Chlamydomonas]
  • (Q08732) S.cerevisiae chromosome XV reading frame ORF YOR267c [cerv4932.FASTAC]
  • HRK1 SGDID:S000005793, Chr XV from 824864-822585, reverse complement, Verified ORF, "Protein kinase implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • HRK1 SGDID:S000005793, Chr XV from 824866-822587, reverse complement, Verified ORF, "Protein kinase implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis" [yeast-contam.fasta]
  • Serine/threonine-protein kinase HRK1 (Hygromycin resistance kinase 1) [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Protein kinase implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis; Hrk1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Serine/threonine-protein kinase HRK1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HRK1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • HRK1 SGDID:S000005793, Chr XV from 824867-822588, Genome Release 64-1-1, reverse complement, Verified ORF, "Protein kinase implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis" [yeast-030211-contam.fasta]
  • HRK1 SGDID:S000005793, Chr XV from 824867-822588, Genome Release 64-2-1, reverse complement, Verified ORF, "Protein kinase; implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis; protein abundance increases in response to DNA replication stress" [20141208_orf_trans.fasta]
  • YOR267C SGDID:S000005793, Chr XV from 824867-822588, Genome Release 64-1-1, reverse complement, Verified ORF, "Protein kinase implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 759 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: cellular ion homeostasis [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: protein kinase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPNLLSRNPF HGHHNDHHHD RENSSNNPPQ LIRSSKSFLN FIGRKQSNDS LRSEKSTDSM  60
   61 KSTTTTTNYT TTNLNNNTHS HSNATSISTN NYNNNYETNH HHNISHGLHD YTSPASPKQT 120
  121 HSMAELKRFF RPSVNKKLSM SQLRSKKHST HSPPPSKSTS TVNLNNHYRA QHPHGFTDHY 180
  181 AHTQSAIPPS TDSILSLSNN INIYHDDCIL AQKYGKLGKL LGSGAGGSVK VLVRPTDGAT 240
  241 FAVKEFRPRK PNESVKEYAK KCTAEFCIGS TLHHPNVIET VDVFSDSKQN KYYEVMEYCP 300
  301 IDFFAVVMTG KMSRGEINCC LKQLTEGVKY LHSMGLAHRD LKLDNCVMTS QGILKLIDFG 360
  361 SAVVFRYPFE DGVTMAHGIV GSDPYLAPEV ITSTKSYDPQ CVDIWSIGII YCCMVLKRFP 420
  421 WKAPRDSDDN FRLYCMPDDI EHDYVESARH HEELLKERKE KRQRFLNHSD CSAINQQQPA 480
  481 HESNLKTVQN QVPNTPASIQ GKSDNKPDIV EEETEENKED DSNNDKESTP DNDKESTIDI 540
  541 KISKNENKST VVSANPKKVD ADADADCDAN GDSNGRVDCK ANSDCNDKTD CNANNDCSNE 600
  601 SDCNAKVDTN VNTAANANPD MVPQNNPQQQ QQQQQQQQQQ QQQQQQQHHH HQHQNQDKAH 660
  661 SIASDNKSSQ QHRGPHHKKI IHGPYRLLRL LPHASRPIMS RILQVDPKKR ATLDDIFNDE 720
  721 WFAAIAACTM DSKNKVIRAP GHHHTLVREE NAHLETYKV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) HRK1 SAP185
    View Details Gavin AC, et al. (2006) CDC25 HRK1 MDS3 SAP185 SIT4
    View Details Gavin AC, et al. (2002) ACC1 AVT4 BEM2 CCT2 CDC25 FAB1 HRK1 MDS3 MIA40 MRPL3 SAP155 SAP185 SAP190 SIT4 SWT21
    View Details Ho Y, et al. (2002) GPH1 HRK1 PST2 ROD1 SIP1 SNF4

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data HRK1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..181] deduced N/A No confident structure predictions are available.
    2 View Details [182..298] PSI-BLAST 295.54902 Cyclin-dependent PK, CDK2
    3 View Details [299..380]
    [496..537]    		 PSI-BLAST 295.54902 Cyclin-dependent PK, CDK2
    4 View Details [381..432] PSI-BLAST 295.54902 Cyclin-dependent PK, CDK2
    5 View Details [433..495] PSI-BLAST 295.54902 Cyclin-dependent PK, CDK2
    6 View Details [538..759] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • protein kinase activity
    		•  2.08446867830553 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  2.03708864261503 bayes_pls_golite062009
  • binding
    		•  1.91026430843897 bayes_pls_golite062009
  • kinase activity
    		•  1.80709202193001 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  1.49093744407686 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.35441545960336 bayes_pls_golite062009
  • protein binding
    		•  1.12583111976692 bayes_pls_golite062009
  • transferase activity
    		•  0.876865688160088 bayes_pls_golite062009
  • molecular adaptor activity
    		•  0.461801827875362 bayes_pls_golite062009
  • SH3/SH2 adaptor activity
    		•  0.366024782440962 bayes_pls_golite062009
  • protein binding, bridging
    		•  0.25357576643216 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle