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Protein Overview: DED1

General Information:
Name(s) found: DED1 / YOR204W [SGD]
Description(s) found:
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  • pir||S13653 ATP-dependent RNA helicase DED1 - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|6324778|ref|NP_014847.1| ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, required for translation initiation of all yeast mRNAs; mutations in human DEAD-box DBY are a frequent cause of male infertility; Ded1p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|3647|emb|CAA40546.1| Ded1p (Spp81p) [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1420479|emb|CAA99419.1| DED1 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|118411|sp|P06634.2|DED1_YEAST RecName: Full=ATP-dependent RNA helicase DED1; AltName: Full=DEAD box protein 1 [NCBI NR]
  • ATP-dependent RNA helicase DED1 OS=Saccharomyces cerevisiae GN=DED1 PE=1 SV=2 [Swiss-Prot]
  • DED1 ATP-dependent RNA helicase [mips]
  • ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, required for translation initiation of all yeast mRNAs; mutations in human DEAD-box DBY are a frequent cause of male infertility [SGD]
  • (P06634) Probable ATP-dependent RNA helicase DED1 [4932.FASTACCERV.txt]
  • Chr XV from 722911-724725 [hmr_yeast5_DM3-1_pombe.fasta]
  • Chr XV from 722910-724724 [yeastorf3.fasta]
  • DED1, Chr XV from 722910-724724 [yeast_orfs2]
  • DED1 SGDID:S0005730, Chr XV from 722911-724725, Verified ORF [yeastflysequest.fasta]
  • ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, required for translation initiation of all yeast mRNAs [Saccharomyces cerevisiae]gi|1420479|emb|CAA99419.1| DED1 [Saccharomyces cerevisiae]gi|3647|emb|CAA40546.1| Ded1p (Spp81p) [Saccharomyces cerev [nrdb_11152004_Chlamydomonas]
  • DED1 SGDID:S000005730, Chr XV from 722911-724725, Verified ORF, "ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, required for translation initiation of all yeast mRNAs; mutations in human DEAD-box DBY are a frequent cause of male infertility" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • DED1 SGDID:S000005730, Chr XV from 722912-724726, Verified ORF, "ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, required for translation initiation of all yeast mRNAs; mutations in human DEAD-box DBY are a frequent cause of male infertility" [yeast-contam.fasta]
  • Ded1p (Spp81p) [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • ATP-dependent RNA helicase DED1 (DEAD box protein 1) [nr-271106-contam.fasta]
  • DED1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, required for translation initiation of all yeast mRNAs; mutations in human DEAD-box DBY are a frequent cause of male infertility; Ded1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • ATP-dependent RNA helicase DED1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DED1 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • DED1 SGDID:S000005730, Chr XV from 722911-724725, Genome Release 64-1-1, Verified ORF, "ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, required for translation initiation of all yeast mRNAs; mutations in human DEAD-box DBY are a frequent cause of male infertility" [yeast-030211-contam.fasta]
  • DED1 SGDID:S000005730, Chr XV from 722911-724725, Genome Release 64-2-1, Verified ORF, "ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase; required for translation initiation of all yeast mRNAs; binds to mRNA cap-associated factors, and binding stimulates Ded1p RNA-dependent ATPase activity; mutation in human homolog DBY is associated with male infertility; human homolog DDX3X complements ded1 null mutation; DED1 has a paralog, DBP1, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
  • YOR204W SGDID:S000005730, Chr XV from 722911-724725, Genome Release 64-1-1, Verified ORF, "ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, required for translation initiation of all yeast mRNAs; mutations in human DEAD-box DBY are a frequent cause of male infertility" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 604 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [ICLink to PubMed article]
    Biological Process: RNA splicing [IDALink to PubMed article]
    translational initiation [IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: RNA helicase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAELSEQVQN LSINDNNENG YVPPHLRGKP RSARNNSSNY NNNNGGYNGG RGGGSFFSNN  60
   61 RRGGYGNGGF FGGNNGGSRS NGRSGGRWID GKHVPAPRNE KAEIAIFGVP EDPNFQSSGI 120
  121 NFDNYDDIPV DASGKDVPEP ITEFTSPPLD GLLLENIKLA RFTKPTPVQK YSVPIVANGR 180
  181 DLMACAQTGS GKTGGFLFPV LSESFKTGPS PQPESQGSFY QRKAYPTAVI MAPTRELATQ 240
  241 IFDEAKKFTY RSWVKACVVY GGSPIGNQLR EIERGCDLLV ATPGRLNDLL ERGKISLANV 300
  301 KYLVLDEADR MLDMGFEPQI RHIVEDCDMT PVGERQTLMF SATFPADIQH LARDFLSDYI 360
  361 FLSVGRVGST SENITQKVLY VENQDKKSAL LDLLSASTDG LTLIFVETKR MADQLTDFLI 420
  421 MQNFRATAIH GDRTQSERER ALAAFRSGAA TLLVATAVAA RGLDIPNVTH VINYDLPSDV 480
  481 DDYVHRIGRT GRAGNTGLAT AFFNSENSNI VKGLHEILTE ANQEVPSFLK DAMMSAPGSR 540
  541 SNSRRGGFGR NNNRDYRKAG GASAGGWGSS RSRDNSFRGG SGWGSDSKSS GWGNSGGSNN 600
  601 SSWW

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) ADH2 AIR1 AIR2 DED1 GYP5 HRB1 IDH1 ILV5 IMD4 LYS12 MET18 MRPS35 NPL3 PAP2 PHO84 PRE10 QCR2 RVS167 SES1 SRP1 URA7 YLR243W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run TOR1 No Comments Reinke A, et al. (2004)
    View Run HSL7 No Comments McCusker D, et al (2007)
    View Run TOR2 No Comments Reinke A, et al. (2004)
    View Run LST8 No Comments Reinke A, et al. (2004)
    View Run TOR2 No Comments Reinke A, et al. (2004)
    View Run KOG1 No Comments Reinke A, et al. (2004)
    View Run SEC10 No Comments De Craene, J., et al. (2006)
    View Run BIR1 No Comments Widlund PO, et al. (2005)
    View Run BIR1 No Comments Widlund PO, et al. (2005)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run MIH1 control 1 McCusker D, et al (2007)
    View Run MIH1 control 2 McCusker D, et al (2007)
    View Run MIH1 experimental1 - mih1-1 McCusker D, et al (2007)
    View Run MIH1 experimental2 - mih1-2 McCusker D, et al (2007)
    View Run RLF2 cac1: TAP-tagged Green EM, et al (2005)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)
    View Run RLF2 identification data - first search in cascade Green EM, et al (2005)
    View Run ASF1 sample 3928 - Asf1-S-TEV-ZZ (in hir3delta mutant) Green EM, et al (2005)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi1 with gst from october 2005 McCusker D, et al (2007)
    View Run BOI1 Sample bob1 (2nd set) from october 2005 McCusker D, et al (2007)
    View Run BOI2 Boi 2 gst control McCusker D, et al (2007)
    View Run VAM3 Sample: HX11 - both fusion and trans-SNARE complex formation take place. Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX14 - mixture in detergent (control). Hao Xu, et al. (2010)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #13 Mitotic Prep2-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #02 Alpha Factor Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run MLP2 #06 Alpha Factor Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #08 Alpha Factor Prep4-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..142] ORFEUS 7.22 Fibrinogen
    2 View Details [143..369] PSI-BLAST 672.218487 Putative DEAD box RNA helicase
    3 View Details [370..544] PSI-BLAST 672.218487 Putative DEAD box RNA helicase
    4 View Details [545..604] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle