Protein Overview: HUB1

General Information:
Name(s) found:	HUB1 / YNR032C-A [SGD]
Description(s) found: SHOW ONLY BEST	gi\|83305829\|sp\|Q6Q546.2\|HUB1_YEAST RecName: Full=Ubiquitin-like modifier HUB1 [NCBI NR] gi\|7493880\|pir\|\|S78735 protein YNR032c-a - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|6324360\|ref\|NP_014430.1\| Ubiquitin-like protein modifier, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear; Hub1p [Saccharomyces cerevisiae] [NCBI NR] Ubiquitin-like modifier HUB1 OS=Saccharomyces cerevisiae GN=HUB1 PE=1 SV=2 [Swiss-Prot] HUB1 Ubiquitin-like protein modifier, may function in modification of Sph1p and Hbt1p [mips] Ubiquitin-like protein modifier, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear [SGD] Chr XIV from 687461-687240, reverse complement [hmr_yeast5_DM3-1_pombe.fasta] Chr XIV from 687240-687461, reverse complement [yeastorf3.fasta] HUB1, Chr XIV from 687240-687461, reverse complement [yeast_orfs2] HUB1 SGDID:S0007251, Chr XIV from 687463-687242, reverse complement, Verified ORF [yeastflysequest.fasta] HUB1 SGDID:S0007251, Chr XIV from 687464-687243, reverse complement, Verified ORF [10112005cervSGD.fasta] Hub1p [Saccharomyces cerevisiae]gi\|7493880\|pir\|\|S78735 protein YNR032c-a - yeast (Saccharomyces cerevisiae) [nrdb_11152004_Chlamydomonas] HUB1 SGDID:S000007251, Chr XIV from 687466-687245, reverse complement, Verified ORF, "Ubiquitin-like protein modifier, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] protein YNR032c-a - yeast (Saccharomyces cerevisiae) [nr-271106-contam.fasta] Ubiquitin-like protein modifier, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear; Hub1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Ubiquitin-like modifier HUB1 [nr-271106-contam.fasta] HUB1 SGDID:S000007251, Chr XIV from 687467-687246, reverse complement, Verified ORF, "Ubiquitin-like protein modifier, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct [SGD_S-cerevisiae_na_01-05-2010_reversed.fasta] HUB1 SGDID:S000007251, Chr XIV from 687466-687245, reverse complement, Verified ORF, "Ubiquitin-like protein modifier, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear" [yeast-bovrabprots.fasta] [chemostatdb.fasta] HUB1 SGDID:S000007251, Chr XIV from 687467-687246, reverse complement, Verified ORF, "Ubiquitin-like protein modifier, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear" [SGDyeast.20101221.fasta] Ubiquitin-like modifier HUB1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HUB1 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] HUB1 SGDID:S000007251, Chr XIV from 687464-687243, Genome Release 64-1-1, reverse complement, Verified ORF, "Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear" [yeast-030211-contam.fasta] HUB1 SGDID:S000007251, Chr XIV from 687464-687243, Genome Release 64-2-1, reverse complement, Verified ORF, "Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear" [20141208_orf_trans.fasta] YNR032C-A SGDID:S000007251, Chr XIV from 687464-687243, Genome Release 64-1-1, reverse complement, Verified ORF, "Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	73 amino acids
Gene Ontology:
Cellular Component:	mating projection [IPI]
Biological Process:	protein modification process [IDA] cell morphogenesis involved in conjugation with cellular fusion [IMP] nuclear mRNA splicing, via spliceosome [IPI][ISS]
Molecular Function:	protein tag [IDA][ISS]

Sequence:
Sequence: [PDR BLAST] [ProtParam]	1 11 21 31 41 51 \| \| \| \| \| \| 1 MIEVVVNDRL GKKVRVKCLA EDSVGDFKKV LSLQIGTQPN KIVLQKGGSV LKDHISLEDY 60 61 EVHDQTNLEL YYL

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	HUB1	SNU66	2	Unpublished Fields Lab Data
View Screen	HUB1	SNU66	2	Unpublished Fields Lab Data
View Screen	HUB1	SNU66	2	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..73]	PSI-BLAST	2.045757	Ubiquitin

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
small conjugating protein ligase activity	3.47895265760328	bayes_pls_golite062009
ubiquitin-protein ligase activity	2.99122127270119	bayes_pls_golite062009
binding	2.5881743465274	bayes_pls_golite062009
acid-amino acid ligase activity	2.56275248067993	bayes_pls_golite062009
protein tag	2.15059229834935	bayes_pls_golite062009
protein binding	1.76858817153382	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	1.25223828115784	bayes_pls_golite062009
transcription regulator activity	1.11533445164506	bayes_pls_golite062009
RNA binding	1.00651240292915	bayes_pls_golite062009
nucleic acid binding	0.896431097217265	bayes_pls_golite062009
DNA binding	0.859811565165317	bayes_pls_golite062009
SUMO ligase activity	0.80391127659342	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.536856055841234	bayes_pls_golite062009
kinase activity	0.506057697290914	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.410719674374641	bayes_pls_golite062009
protein kinase activity	0.325253662829604	bayes_pls_golite062009
transferase activity	0.236208643697075	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2