Protein Overview: YPK2

General Information:
Name(s) found:	YPK2 / YMR104C [SGD]
Description(s) found: SHOW ONLY BEST	pir\|\|JS0178 protein kinase YKR2 (EC 2.7.1.-) - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|817862\|emb\|CAA89740.1\| Ypk2p [Saccharomyces cerevisiae] [NCBI NR] gi\|6323751\|ref\|NP_013822.1\| Protein kinase with similarityto serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian k [NCBI NR] gi\|295681\|gb\|AAA78259.1\| protein kinase [Saccharomyces cerevisiae] [NCBI NR] gi\|140977\|sp\|P18961.1\|YPK2_YEAST RecName: Full=Serine/threonine-protein kinase YPK2/YKR2 [NCBI NR] Serine/threonine-protein kinase YPK2/YKR2 OS=Saccharomyces cerevisiae GN=YPK2 PE=1 SV=1 [Swiss-Prot] YPK2 Ser/thr protein kinase [mips] Protein kinase with similarity to serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK [SGD] YPK2, Chr XIII from 473419-475452, reverse complement [yeast_orfs2] Chr XIII from 473419-475452, reverse complement [yeastorf3.fasta] Chr XIII from 475452-473419, reverse complement [yeastorf5.fasta] (P18961) Serine/threonine-protein kinase YPK2/YKR2 (EC 2.7.1.37) [4932.FASTACCERV.txt] YPK2 SGDID:S0004710, Chr XIII from 475452-473419, reverse complement, Verified ORF [yeastflysequest.fasta] Ypk2p [Saccharomyces cerevisiae]gi\|817862\|emb\|CAA89740.1\| Ypk2p [Saccharomyces cerevisiae]gi\|140977\|sp\|P18961\|YPK2_YEAST Serine/threonine-protein kinase YPK2/YKR2gi\|83415\|pir\|\|JS0178 protein kinase YKR2 (EC 2.7.1.-) - yeast (Saccharomyces cerevisiae)g [nrdb_11152004_Chlamydomonas] YPK2 SGDID:S000004710, Chr XIII from 475452-473419, reverse complement, Verified ORF, "Protein kinase with similarityto serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway requi [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] YPK2 SGDID:S000004710, Chr XIII from 475452-473419, reverse complement, Verified ORF, "Protein kinase with similarity to serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway requ [yeast-200209-contam.fasta] Ypk2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] protein kinase [nr-271106-contam.fasta] Protein kinase with similarityto serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK; Ypk2p [Saccharomy [nr-271106-contam.fasta] Serine/threonine-protein kinase YPK2/YKR2 [nr-271106-contam.fasta] YPK2 SGDID:S000004710, Chr XIII from 475452-473419, reverse complement, Verified ORF, "Protein kinase with similarity to serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK" [yeast-bovrabprots.fasta] YPK2 SGDID:S000004710, Chr XIII from 475452-473419, reverse complement, Verified ORF, "Protein kinase with similarityto serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK" [yeast-contam_custom.fasta] [chemostatdb.fasta] Serine/threonine-protein kinase YPK2/YKR2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YPK2 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] YPK2 SGDID:S000004710, Chr XIII from 475453-473420, Genome Release 64-1-1, reverse complement, Verified ORF, "Protein kinase with similarity to serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK" [yeast-030211-contam.fasta] YPK2 SGDID:S000004710, Chr XIII from 475453-473420, Genome Release 64-2-1, reverse complement, Verified ORF, "Protein kinase similar to serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK; YPK2 has a paralog, YPK1, that arose from the whole genome duplication" [20141208_orf_trans.fasta] YMR104C SGDID:S000004710, Chr XIII from 475453-473420, Genome Release 64-1-1, reverse complement, Verified ORF, "Protein kinase with similarity to serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	677 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] cytoplasm [IDA]
Biological Process:	protein amino acid phosphorylation [ISS]
Molecular Function:	protein kinase activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHSWRISKFK LGRSKEDDGS SEDENEKSWG NGLFHFHHGE KHHDGSPKNH NHEHEHHIRK  60
   61 INTNETLPSS LSSPKLRNDA SFKNPSGIGN DNSKASERKA SQSSTETQGP SSESGLMTVK 120
  121 VYSGKDFTLP FPITSNSTIL QKLLSSGILT SSSNDASEVA AIMRQLPRYK RVDQDSAGEG 180
  181 LIDRAFATKF IPSSILLPGS TNSSPLLYFT IEFDNSITTI SPDMGTMEQP VFNKISTFDV 240
  241 TRKLRFLKID VFARIPSLLL PSKNWQQEIG EQDEVLKEIL KKINTNQDIH LDSFHLPLNL 300
  301 KIDSAAQIRL YNHHWISLER GYGKLNITVD YKPSKNKPLS IDDFDLLKVI GKGSFGKVMQ 360
  361 VRKKDTQKIY ALKALRKAYI VSKCEVTHTL AERTVLARVD CPFIVPLKFS FQSPEKLYLV 420
  421 LAFINGGELF YHLQHEGRFS LARSRFYIAE LLCALDSLHK LDVIYRDLKP ENILLDYQGH 480
  481 IALCDFGLCK LNMKDNDKTD TFCGTPEYLA PEILLGQGYT KTVDWWTLGI LLYEMMTGLP 540
  541 PYYDENVPVM YKKILQQPLL FPDGFDPAAK DLLIGLLSRD PSRRLGVNGT DEIRNHPFFK 600
  601 DISWKKLLLK GYIPPYKPIV KSEIDTANFD QEFTKEKPID SVVDEYLSAS IQKQFGGWTY 660
  661 IGDEQLGDSP SQGRSIS

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		SYP1 YPK2
View Details	Krogan NJ, et al. (2006)		TEC1 YPK1 YPK2
View Details	Ho Y, et al. (2002)		CDC33 PET112 PRB1 SNF1 TFP1 YEL023C YGR016W YPK2

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	UBC6	YPK2	2	Unpublished Fields Lab Data
View Screen	CDC23	YPK2	1	Unpublished Fields Lab Data
View Screen	LIA1	YPK2	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	YPK2	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..151]	deduced	N/A	No confident structure predictions are available.
2	View Details	[152..280]	PSI-BLAST	12.522879	Photoreceptor phy3 flavin-binding domain, lov2
3	View Details	[281..335] [387..407] [423..624]	PSI-BLAST	856.9794	cAMP-dependent PK, catalytic subunit
4	View Details	[336..386] [408..422] [625..677]	PSI-BLAST	856.9794	cAMP-dependent PK, catalytic subunit

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.96

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2