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Protein Overview: TUS1

General Information:
Name(s) found: TUS1 / YLR425W [SGD]
Description(s) found:
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  • gi|74644962|sp|Q06412.1|TUS1_YEAST RecName: Full=Rho1 guanine nucleotide exchange factor TUS1; AltName: Full=TOR unique function suppressor protein 1 [NCBI NR]
  • gi|664876|gb|AAB67506.1| Ylr425wp [Saccharomyces cerevisiae] [NCBI NR]
  • gi|6323457|ref|NP_013529.1| Guanine nucleotide exchange factor (GEF) that functions to modulate Rho1p activity as part of the cell integrity signaling pathway; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate [NCBI NR]
  • pir||S53412 probable membrane protein YLR425w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • Rho1 guanine nucleotide exchange factor TUS1 OS=Saccharomyces cerevisiae GN=TUS1 PE=1 SV=1 [Swiss-Prot]
  • TUS1 Guanine nucleotide exchange factor (GEF) that functions to modulate Rhop1 activity as part of the cell integrity signaling pathway [mips]
  • Guanine nucleotide exchange factor (GEF) that functions to modulate Rho1p activity as part of the cell integrity signaling pathway; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate [SGD]
  • TUS1, Chr XII from 982889-986812 [yeast_orfs2]
  • Chr XII from 982889-986812 [yeastorf3.fasta]
  • >Q06412 (Q06412) Chromosome XII COSMID 9576 [4932.FASTACCERV.txt]
  • TUS1 SGDID:S0004417, Chr XII from 982890-986813, Verified ORF [yeastflysequest.fasta]
  • Guanine nucleotide exchange factor (GEF) that functions to modulate Rhop1 activity as part of the cell integrity signaling pathway; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate [Saccharomyces cerevisiae] [nrdb_11152004_Chlamydomonas]
  • (Q06412) Ylr425wp [cerv4932.FASTAC]
  • TUS1 SGDID:S000004417, Chr XII from 982890-986813, Verified ORF, "Guanine nucleotide exchange factor (GEF) that functions to modulate Rhop1 activity as part of the cell integrity signaling pathway; multicopy suppressor of tor2 mutation and ypk1 ypk2 doubl [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • TUS1 SGDID:S000004417, Chr XII from 982891-986814, Verified ORF, "Guanine nucleotide exchange factor (GEF) that functions to modulate Rho1p activity as part of the cell integrity signaling pathway; multicopy suppressor of tor2 mutation and ypk1 ypk2 doubl [yeast-contam.fasta]
  • Rho1 guanine nucleotide exchange factor TUS1 (TOR unique function suppressor protein 1) [nr-271106-contam.fasta]
  • Guanine nucleotide exchange factor (GEF) that functions to modulate Rho1p activity as part of the cell integrity signaling pathway; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate; Tus1p [Saccharomyces cerev [nr-271106-contam.fasta]
  • Ylr425wp [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • TUS1 SGDID:S000004417, Chr XII from 982891-986814, Verified ORF, "Guanine nucleotide exchange factor (GEF) that functions to modulate Rho1p activity as part of the cell integrity signaling pathway; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Rho1 guanine nucleotide exchange factor TUS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TUS1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • TUS1 SGDID:S000004417, Chr XII from 982894-986817, Genome Release 64-1-1, Verified ORF, "Guanine nucleotide exchange factor (GEF) that functions to modulate Rho1p activity as part of the cell integrity signaling pathway; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate" [yeast-030211-contam.fasta]
  • TUS1 SGDID:S000004417, Chr XII from 982894-986817, Genome Release 64-2-1, Verified ORF, "Guanine nucleotide exchange factor (GEF) that modulate Rho1p activity; involved in the cell integrity signaling pathway; interacts with Rgl1p; localization of Tus1p to the bed neck is regulated by Rgl1p; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate" [20141208_orf_trans.fasta]
  • YLR425W SGDID:S000004417, Chr XII from 982894-986817, Genome Release 64-1-1, Verified ORF, "Guanine nucleotide exchange factor (GEF) that functions to modulate Rho1p activity as part of the cell integrity signaling pathway; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 1307 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: signal transduction [IGILink to PubMed article][IMPLink to PubMed article]
    cellular cell wall organization [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: Rho guanyl-nucleotide exchange factor activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYRYNRSSPF ERTPEKRVSR QESQRKSIEL PKLPPLNTRN SFLDDSDNGT DNISIGWTPI  60
   61 SDTQQFQSPV PQAFTFTSKH SARGNGTSSS ESTPKSTKYV KERRPPPPPP LLYSTESIRI 120
  121 DSPMVSPSSQ SRERSPNKLS FIGNSEERHH MEYISNHSRI LKSPFANGFS PNSPKSPRDS 180
  181 SKQQAHFSDE SDLRCHEREK ALPPIPFTTT LLLSPFDDED SEFFTKPPPP LSTSRNVSGN 240
  241 SRVSEALESV YSDSDYTFNN SNARQSSFNS LLGAKPLELA PSITAPTQPF SIQSIDEHKL 300
  301 YQCDNVYKLS AIYEWILKVY FEWFNECVFT KIDLFQIVQL LLEFQMPTNF DQDTIDSNVD 360
  361 NIMASFISQK AVRFDIINDE EVAVVVGGLD ITGVFTELLP CYSFIDNTYG STNSLICYSN 420
  421 VCTHGQSSGF RKEIKLSEII NKSVGLWTEY WHLTPDDLAE INPREVQRQS FIFDLIILEE 480
  481 RSLNMATAAV EIYGKRFDKS LLPDEPEFKA LAFDIFEPLI QLHTEFLLTP IFWKLKTRGK 540
  541 FIDGVGKIYS KWCGEAKNIY LNYAKAMATV HEIIMWEKKN KTKFVTWLKE IDNSVEITRS 600
  601 KMYHDVIFFG GFFKSLQNMP VTLRSILKNT DPSMEDYEYL KIVIKEVEKL NFEVNQVHGL 660
  661 AIDHRKLVRF SKQLVLSTNS SNATSYVNVG GSTNANDDDA IQDKLALGLT YPERKLVLSG 720
  721 TVYKKRDLWL DPTPVYIALL DNCLLITEEI SKGETQKYKL IERPIPIDYL SLEKRKIPGT 780
  781 SKQPLRNYSQ KEHKSPMHNF STPINSMRPL LKSSGNHMST AYGDRKTSNT EISNANPNTD 840
  841 EFSFKIRNTA TGESFKFFTE SAEVLNQWID AIMESFKRNA ENHDLNAFEF TVLSSEFAYF 900
  901 DKDAPVNLPV APEGSEIDVA LKAYAQKANK DSCSWSKTTR ILCCEDVKFE GRIYLFVATT 960
  961 DGIYVKYRDD YGSGFVKILE LNDVKRMEAN VKLGLLFVLD NRKLCYFNIS TVVSRYLAQG1020
 1021 NTLDENCIVG TVIRDKVRFF KIADDFGNSK HLFFERKGKI VILTPEFDQL TNQVKYFKFY1080
 1081 KEYKLPSSSN NILNNEIEDI AIFRKSFAVC TKKTVILYQD SFEDNGIVLP SFLNDKDMMA1140
 1141 HLRHPHLNSL PFKSATDSKK RPSIESLTEE AKKDIATCKA IPVNFFQISQ SSFFALVYDE1200
 1201 AVVKINCYGE MSDWRKDILL LDFCCTGASF HGNHLILVGD NLIQIYDLKN VEQNLGELVP1260
 1261 VQIIKGKKIK LASSERREKT ILVLSHPNIL NRQLLVACNP VAMADHQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) TUS1 YPL066W
    View Details Krogan NJ, et al. (2006) TUS1 YPL066W
    View Details Gavin AC, et al. (2002) ACK1 IPP1 PPA2 PRP43 ROM2 TUS1 YPL066W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..304] ab initio 13.25 No description for 1m2vB was found.
    2 View Details [305..442] deduced N/A No confident structure predictions are available.
    3 View Details [443..660] PSI-BLAST 84.68867 GEF of intersectin
    4 View Details [661..827] PSI-BLAST 84.68867 GEF of intersectin
    5 View Details [828..1307] MSA 8.041981 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle