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Protein Overview: LHS1

General Information:
Name(s) found: LHS1 / YKL073W [SGD]
Description(s) found:
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  • gi|6322777|ref|NP_012850.1| Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; member of the Hsp70 family; localizes to the lumen of the ER; regulated by the unfolded protein response pathway; Lhs1p [NCBI NR]
  • gi|549693|sp|P36016.1|LHS1_YEAST RecName: Full=Heat shock protein 70 homolog LHS1; Flags: Precursor [NCBI NR]
  • pir||S37895 LHS1 protein precursor - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|486103|emb|CAA81910.1| LHS1 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|433627|emb|CAA53401.1| A881; Hsp70 homologue [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1587570|prf||2206496B ORF [NCBI NR]
  • Heat shock protein 70 homolog LHS1 OS=Saccharomyces cerevisiae GN=LHS1 PE=1 SV=1 [Swiss-Prot]
  • LHS1 Chaperone of the ER lumen [mips]
  • Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; regulated by the unfolded protein response pathway [SGD]
  • LHS1, Chr XI from 296072-298717 [yeast_orfs2]
  • Chr XI from 296072-298717 [yeastorf3.fasta]
  • Chr XI from 296071-298716 [yeastorf4.fasta]
  • (P36016) Heat shock protein 70 homolog LHS1 precursor [4932.FASTACCERV.txt]
  • LHS1 SGDID:S0001556, Chr XI from 296075-298720, Verified ORF [yeastflysequest.fasta]
  • Lhs1p [Saccharomyces cerevisiae]gi|433627|emb|CAA53401.1| A881; Hsp70 homologue [Saccharomyces cerevisiae]gi|486103|emb|CAA81910.1| LHS1 [Saccharomyces cerevisiae]gi|539120|pir||S37895 LHS1 protein precursor - yeast (Saccharomyces cerevisiae)gi|549693 [nrdb_11152004_Chlamydomonas]
  • LHS1 SGDID:S000001556, Chr XI from 296074-298719, Verified ORF, "Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; member of the Hsp70 family; localizes to the lumen of the ER; regulated by the unfo [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • ORF [nr-271106-contam.fasta]
  • Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; member of the Hsp70 family; localizes to the lumen of the ER; regulated by the unfolded protein response pathway; Lhs1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • LHS1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • A881; Hsp70 homologue [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Heat shock protein 70 homolog LHS1 precursor [nr-271106-contam.fasta]
  • LHS1 SGDID:S000001556, Chr XI from 296074-298719, Verified ORF, "Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; regulated by t [SGD_S-cerevisiae_na_01-05-2010_reversed.fasta]
  • LHS1 SGDID:S000001556, Chr XI from 296074-298719, Verified ORF, "Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; member of the Hsp70 family; localizes to the lumen of the ER; regulated by the unfolded protein response pathway" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • LHS1 SGDID:S000001556, Chr XI from 296074-298719, Verified ORF, "Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; regulated by the unfolded protein response pathway" [SGDyeast.20101221.fasta]
  • Heat shock protein 70 homolog LHS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LHS1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • LHS1 SGDID:S000001556, Chr XI from 296430-299075, Genome Release 64-1-1, Verified ORF, "Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; regulated by the unfolded protein response pathway" [yeast-030211-contam.fasta]
  • LHS1 SGDID:S000001556, Chr XI from 296430-299075, Genome Release 64-2-1, Verified ORF, "Molecular chaperone of the endoplasmic reticulum lumen; involved in polypeptide translocation and folding; nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; regulated by the unfolded protein response pathway" [20141208_orf_trans.fasta]
  • YKL073W SGDID:S000001556, Chr XI from 296430-299075, Genome Release 64-1-1, Verified ORF, "Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; regulated by the unfolded protein response pathway" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 881 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum lumen [IDALink to PubMed article][ISSLink to PubMed article][TASLink to PubMed article]
    Biological Process: protein transport [IGILink to PubMed article][IMPLink to PubMed article]
    response to unfolded protein [IGILink to PubMed articleLink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: unfolded protein binding [IGILink to PubMed articleLink to PubMed article][IMPLink to PubMed articleLink to PubMed articleLink to PubMed article][IPILink to PubMed article][ISSLink to PubMed articleLink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRNVLRLLFL TAFVAIGSLA AVLGVDYGQQ NIKAIVVSPQ APLELVLTPE AKRKEISGLS  60
   61 IKRLPGYGKD DPNGIERIYG SAVGSLATRF PQNTLLHLKP LLGKSLEDET TVTLYSKQHP 120
  121 GLEMVSTNRS TIAFLVDNVE YPLEELVAMN VQEIANRANS LLKDRDARTE DFVNKMSFTI 180
  181 PDFFDQHQRK ALLDASSITT GIEETYLVSE GMSVAVNFVL KQRQFPPGEQ QHYIVYDMGS 240
  241 GSIKASMFSI LQPEDTTQPV TIEFEGYGYN PHLGGAKFTM DIGSLIENKF LETHPAIRTD 300
  301 ELHANPKALA KINQAAEKAK LILSANSEAS INIESLINDI DFRTSITRQE FEEFIADSLL 360
  361 DIVKPINDAV TKQFGGYGTN LPEINGVILA GGSSRIPIVQ DQLIKLVSEE KVLRNVNADE 420
  421 SAVNGVVMRG IKLSNSFKTK PLNVVDRSVN TYSFKLSNES ELYDVFTRGS AYPNKTSILT 480
  481 NTTDSIPNNF TIDLFENGKL FETITVNSGA IKNSYSSDKC SSGVAYNITF DLSSDRLFSI 540
  541 QEVNCICQSE NDIGNSKQIK NKGSRLAFTS EDVEIKRLSP SERSRLHEHI KLLDKQDKER 600
  601 FQFQENLNVL ESNLYDARNL LMDDEVMQNG PKSQVEELSE MVKVYLDWLE DASFDTDPED 660
  661 IVSRIREIGI LKKKIELYMD SAKEPLNSQQ FKGMLEEGHK LLQAIETHKN TVEEFLSQFE 720
  721 TEFADTIDNV REEFKKIKQP AYVSKALSTW EETLTSFKNS ISEIEKFLAK NLFGEDLREH 780
  781 LFEIKLQFDM YRTKLEEKLR LIKSGDESRL NEIKKLHLRN FRLQKRKEEK LKRKLEQEKS 840
  841 RNNNETESTV INSADDKTTI VNDKTTESNP SSEEDILHDE L

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) AHA1 AHP1 ARF1 ARP2 ATP3 BCK1 BEM2 COP1 CPR6 DUF1 EDE1 EGD2 FOL2 GAL7 GND1 GPG1 HEF3 HTB1 HTB2 IDH1 IDH2 ILV5 IPP1 KIC1 KIN2 LHS1 LYS12 MDN1 MGE1 MGT1 MKK2 MKT1 NAS6 NIP1 OYE2 PDC6 PIL1 PMA1 POR1 QCR2 RCN2 RIP1 RPG1 RPN1 RPN11 RPN12 RPN14 RPN3 RPN5 RPN6 RPN7 RPN8 RPN9 RPT1 RPT2 RPT3 RPT4 RPT5 SEC27 SES1 SIS1 SKG3 SLT2 SMK1 SOF1 SRV2 STI1 TIF1, TIF2 TIF34 TIF35 TMA19 UBC12 UBI4 UBR1 YHR033W
    View Details Qiu et al. (2008) LHS1 SCJ1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ASF1 3912: TAP-tagged, strain background includes hpc2(delta) Green EM, et al (2005)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)
    View Run MLP2 #34 Asynchronous SPB prep Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data LHS1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..209]
    [420..438]    		 PSI-BLAST 1276.9897 Heat shock protein 70kDa, ATPase fragment
    2 View Details [210..276]
    [356..419]    		 PSI-BLAST 1276.9897 Heat shock protein 70kDa, ATPase fragment
    3 View Details [277..355] PSI-BLAST 1276.9897 Heat shock protein 70kDa, ATPase fragment
    4 View Details [439..602] PSI-BLAST 85.0 DnaK
    5 View Details [603..709] PSI-BLAST 85.0 DnaK
    6 View Details [710..881] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle