Protein Overview: SWE1

General Information:
Name(s) found:	SWE1 / YJL187C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6322274\|ref\|NP_012348.1\| Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate; Swe1p [ [NCBI NR] pir\|\|S40400 protein kinase SWE1 (EC 2.7.1.-) - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|417832\|sp\|P32944.1\|SWE1_YEAST RecName: Full=Mitosis inhibitor protein kinase SWE1; AltName: Full=Wee1 homolog [NCBI NR] gi\|397529\|emb\|CAA52150.1\| SWE1 [Saccharomyces cerevisiae] [NCBI NR] gi\|1008395\|emb\|CAA89482.1\| SWE1 [Saccharomyces cerevisiae] [NCBI NR] Mitosis inhibitor protein kinase SWE1 OS=Saccharomyces cerevisiae GN=SWE1 PE=1 SV=1 [Swiss-Prot] SWE1 Ser/tyr dual-specifity protein kinase [mips] Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate [SGD] SWE1, Chr X from 76802-79261, reverse complement [yeast_orfs2] Chr X from 76802-79261, reverse complement [yeastorf3.fasta] Chr X from 79261-76802, reverse complement [yeastorf5.fasta] (P32944) Mitosis inhibitor protein kinase SWE1 (EC 2.7.1.-) [4932.FASTACCERV.txt] SWE1 SGDID:S0003723, Chr X from 79261-76802, reverse complement, Verified ORF [yeastflysequest.fasta] Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate [Saccharomyces cerevisiae]gi\|100839 [nrdb_11152004_Chlamydomonas] SWE1 SGDID:S000003723, Chr X from 79261-76802, reverse complement, Verified ORF, "Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] SWE1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Mitosis inhibitor protein kinase SWE1 [nr-271106-contam.fasta] Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate; Swe1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] SWE1 SGDID:S000003723, Chr X from 79261-76802, reverse complement, Verified ORF, "Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Mitosis inhibitor protein kinase SWE1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SWE1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] SWE1 SGDID:S000003723, Chr X from 79262-76803, Genome Release 64-1-1, reverse complement, Verified ORF, "Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate" [yeast-030211-contam.fasta] SWE1 SGDID:S000003723, Chr X from 79262-76803, Genome Release 64-2-1, reverse complement, Verified ORF, "Protein kinase that regulates the G2/M transition; regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; phosphorylates conserved tyrosine residue in N-terminus of Hsp90 in cell-cycle associated manner, thus modulating the ability of Hsp90 to chaperone a selected clientele; homolog of S. pombe Wee1p; potential Cdc28p substrate" [20141208_orf_trans.fasta] YJL187C SGDID:S000003723, Chr X from 79262-76803, Genome Release 64-1-1, reverse complement, Verified ORF, "Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	819 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA ] cellular bud neck [IDA ]
Biological Process:	cell morphogenesis checkpoint [IDA][IEP][IMP] [NOT]G2/M transition size control checkpoint [IEP][IMP] G2/M transition of mitotic cell cycle [IDA][IMP][ISS] regulation of cell size [IMP] regulation of meiosis [IEP][IGI][IMP] regulation of cyclin-dependent protein kinase activity [IDA]
Molecular Function:	protein kinase activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSLDEDEED FEMLDTENLQ FMGKKMFGKQ AGEDESDDFA IGGSTPTNKL KFYPYSNNKL  60
   61 TRSTGTLNLS LSNTALSEAN SKFLGKIEEE EEEEEEGKDE ESVDSRIKRW SPFHENESVT 120
  121 TPITKRSAEK TNSPISLKQW NQRWFPKNDA RTENTSSSSS YSVAKPNQSA FTSSGLVSKM 180
  181 SMDTSLYPAK LRIPETPVKK SPLVEGRDHK HVHLSSSKNA SSSLSVSPLN FVEDNNLQED 240
  241 LLFSDSPSSK ALPSIHVPTI DSSPLSEAKY HAHDRHNNQT NILSPTNSLV TNSSPQTLHS 300
  301 NKFKKIKRAR NSVILKNREL TNSLQQFKDD LYGTDENFPP PIIISSHHST RKNPQPYQFR 360
  361 GRYDNDTDEE ISTPTRRKSI IGATSQTHRE SRPLSLSSAI VTNTTSAETH SISSTDSSPL 420
  421 NSKRRLISSN KLSANPDSHL FEKFTNVHSI GKGQFSTVYQ VTFAQTNKKY AIKAIKPNKY 480
  481 NSLKRILLEI KILNEVTNQI TMDQEGKEYI IDYISSWKFQ NSYYIMTELC ENGNLDGFLQ 540
  541 EQVIAKKKRL EDWRIWKIIV ELSLALRFIH DSCHIVHLDL KPANVMITFE GNLKLGDFGM 600
  601 ATHLPLEDKS FENEGDREYI APEIISDCTY DYKADIFSLG LMIVEIAANV VLPDNGNAWH 660
  661 KLRSGDLSDA GRLSSTDIHS ESLFSDITKV DTNDLFDFER DNISGNSNNA GTSTVHNNSN 720
  721 INNPNMNNGN DNNNVNTAAT KNRLILHKSS KIPAWVPKFL IDGESLERIV RWMIEPNYER 780
  781 RPTANQILQT EECLYVEMTR NAGAIIQEDD FGPKPKFFI

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		HAT1 HAT2 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 SWE1 YJR154W
View Details	Ho Y, et al. (2002)		AHC1 CLB2 COP1 HSL7 KEL1 SWE1 UBP15
View Details	Qiu et al. (2008)		ELM1 HSL1 SWE1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)
View Run	BOI1	Sample bob1 (2nd set) from october 2005	McCusker D, et al (2007)
View Run	MLP2	#29 Asynchronous Prep5-TiO2 Flowthrough	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	CDC24	SWE1	2	Drees BL, et al. (2001)
View Screen	BEM1	SWE1	2	Drees BL, et al. (2001)

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	SWE1	Sundin BA, et al. (2004)
View Data	SWE1	Sundin BA, et al. (2004)
View Data	SWE1	Sundin BA, et al. (2004)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..400]	deduced	N/A	No confident structure predictions are available.
2	View Details	[401..499] [513..529]	PSI-BLAST	261.218487	cAMP-dependent PK, catalytic subunit
3	View Details	[500..512] [530..748]	PSI-BLAST	261.218487	cAMP-dependent PK, catalytic subunit
4	View Details	[749..819]	deduced	N/A	Confident ab initio structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2