Protein Overview: GTT1

General Information:
Name(s) found:	GTT1 / YIR038C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|731924\|sp\|P40582.1\|GST1_YEAST RecName: Full=Glutathione S-transferase 1; AltName: Full=GST-I [NCBI NR] gi\|6322229\|ref\|NP_012304.1\| ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p; Gtt1p [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S48500 hypothetical protein YIR038c - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|557844\|emb\|CAA86198.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] (P40582) Glutathione S-transferase I (EC 2.5.1.18) (GST-I) [Swiss-Prot] Glutathione S-transferase 1 OS=Saccharomyces cerevisiae GN=GTT1 PE=1 SV=1 [Swiss-Prot] GTT1 Glutathione S-transferase [mips] ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p [SGD] GTT1, Chr IX from 423806-424510, reverse complement [yeast_orfs2] Chr IX from 423806-424510, reverse complement [yeastorf3.fasta] Chr IX from 424510-423806, reverse complement [yeastorf5.fasta] GTT1 SGDID:S0001477, Chr IX from 424510-423806, reverse complement, Verified ORF [yeastflysequest.fasta] ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p [Saccharomyces cerevisiae]gi\|557844\|emb\|CAA86198.1\| unnamed [nrdb_11152004_Chlamydomonas] GTT1 SGDID:S000001477, Chr IX from 424510-423806, reverse complement, Verified ORF, "ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Glutathione S-transferase I (GST-I) [nr-271106-contam.fasta] ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p; Gtt1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] GTT1 SGDID:S000001477, Chr IX from 424510-423806, reverse complement, Verified ORF, "ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Glutathione S-transferase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GTT1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] GTT1 SGDID:S000001477, Chr IX from 424513-423809, Genome Release 64-1-1, reverse complement, Verified ORF, "ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p" [yeast-030211-contam.fasta] GTT1 SGDID:S000001477, Chr IX from 424513-423809, Genome Release 64-2-1, reverse complement, Verified ORF, "ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p" [20141208_orf_trans.fasta] YIR038C SGDID:S000001477, Chr IX from 424513-423809, Genome Release 64-1-1, reverse complement, Verified ORF, "ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	234 amino acids
Gene Ontology:
Cellular Component:	mitochondrion [IDA ] endoplasmic reticulum [IDA] mitochondrial outer membrane [IDA]
Biological Process:	glutathione metabolic process [IDA]
Molecular Function:	glutathione peroxidase activity [IDA] glutathione transferase activity [IDA][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLPIIKVHW LDHSRAFRLL WLLDHLNLEY EIVPYKRDAN FRAPPELKKI HPLGRSPLLE  60
   61 VQDRETGKKK ILAESGFIFQ YVLQHFDHSH VLMSEDADIA DQINYYLFYV EGSLQPPLMI 120
  121 EFILSKVKDS GMPFPISYLA RKVADKISQA YSSGEVKNQF DFVEGEISKN NGYLVDGKLS 180
  181 GADILMSFPL QMAFERKFAA PEDYPAISKW LKTITSEESY AASKEKARAL GSNF

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	ILM1	GTT1	2	Lockshon D, et al. (2006)
View Screen	GPI14	GTT1	2	Hazbun TR, et al. (2003)

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	GTT1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..89]	PSI-BLAST	50.09691	Class phi GST
2	View Details	[90..234]	PSI-BLAST	50.09691	Class phi GST

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
glutathione transferase activity	4.50796867464992	bayes_pls_golite062009
antioxidant activity	3.8464796631544	bayes_pls_golite062009
peroxidase activity	3.44705858438242	bayes_pls_golite062009
oxidoreductase activity, acting on peroxide as acceptor	3.44705858438242	bayes_pls_golite062009
glutathione binding	2.53131331487579	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	2.23310780102446	bayes_pls_golite062009
peroxiredoxin activity	2.12777217096121	bayes_pls_golite062009
glutathione peroxidase activity	2.012364779649	bayes_pls_golite062009
thioredoxin peroxidase activity	1.96134566495756	bayes_pls_golite062009
selenium binding	1.67987004910726	bayes_pls_golite062009
protein disulfide oxidoreductase activity	1.47769936616412	bayes_pls_golite062009
disulfide oxidoreductase activity	1.32811008894503	bayes_pls_golite062009
oxidoreductase activity	0.896889139171464	bayes_pls_golite062009
protein disulfide isomerase activity	0.866317336989678	bayes_pls_golite062009
intramolecular oxidoreductase activity, transposing S-S bonds	0.866317336989678	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	0.76684639032666	bayes_pls_golite062009
intramolecular oxidoreductase activity, interconverting keto- and enol-groups	0.748123488370707	bayes_pls_golite062009
catalytic activity	0.672192331361968	bayes_pls_golite062009
binding	0.274799360132997	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2