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Protein Overview: YRB2

General Information:
Name(s) found: YRB2 / YIL063C [SGD]
Description(s) found:
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  • gi|731821|sp|P40517.1|YRB2_YEAST RecName: Full=Ran-specific GTPase-activating protein 2; AltName: Full=Ran-binding protein 2; Short=RANBP2 [NCBI NR]
  • gi|6322126|ref|NP_012201.1| Protein of unknown function involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; is not essen [NCBI NR]
  • pir||S48416 hypothetical protein YIL063c - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|557806|emb|CAA86160.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • gi|45269649|gb|AAS56205.1| YIL063C [Saccharomyces cerevisiae] [NCBI NR]
  • Ran-specific GTPase-activating protein 2 OS=Saccharomyces cerevisiae GN=YRB2 PE=1 SV=1 [Swiss-Prot]
  • YRB2 Ran-GTPase-binding protein involved in nuclear protein export [mips]
  • Protein of unknown function involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; is not essential [SGD]
  • YRB2, Chr IX from 242758-243741, reverse complement [yeast_orfs2]
  • Chr IX from 242758-243741, reverse complement [yeastorf3.fasta]
  • Chr IX from 243741-242758, reverse complement [yeastorf5.fasta]
  • (P40517) Ran-specific GTPase-activating protein 2 (Ran binding protein 2) (RANBP2) [4932.FASTACCERV.txt]
  • YRB2 SGDID:S0001325, Chr IX from 243741-242758, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Ran-GTPase-binding protein involved in nuclear export; nuclear protein, interacts with Gsp1p and Crm1p [Saccharomyces cerevisiae]gi|557806|emb|CAA86160.1| unnamed protein product [Saccharomyces cerevisiae]gi|626331|pir||S48416 hypothetical protein YIL06 [nrdb_11152004_Chlamydomonas]
  • YRB2 SGDID:S000001325, Chr IX from 243741-242758, reverse complement, Verified ORF, "Protein of unknown function involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; inter [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Ran-specific GTPase-activating protein 2 (Ran-binding protein 2) (RANBP2) [nr-271106-contam.fasta]
  • Protein of unknown function involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; is not essential; Yrb2p [Saccharomyces c [nr-271106-contam.fasta]
  • YIL063C [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • YRB2 SGDID:S000001325, Chr IX from 243741-242758, reverse complement, Verified ORF, "Protein of unknown function involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; is not essential" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Ran-specific GTPase-activating protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YRB2 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • YRB2 SGDID:S000001325, Chr IX from 243744-242761, Genome Release 64-1-1, reverse complement, Verified ORF, "Protein of unknown function involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; is not essential" [yeast-030211-contam.fasta]
  • YRB2 SGDID:S000001325, Chr IX from 243744-242761, Genome Release 64-2-1, reverse complement, Verified ORF, "Protein of unknown function; involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; relocalizes to the cytosol in response to hypoxia; not essential for viability" [20141208_orf_trans.fasta]
  • YIL063C SGDID:S000001325, Chr IX from 243744-242761, Genome Release 64-1-1, reverse complement, Verified ORF, "Protein of unknown function involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; is not essential" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 327 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article]
    nuclear pore [IDALink to PubMed article]
    Biological Process: ribosomal small subunit export from nucleus [IMPLink to PubMed article]
    protein export from nucleus [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSETNGGNAA RENSEVKQTA VENPIDKLDG TPKRPREKDQ DEQAEETSDK SEAPNKNDEE  60
   61 KKEEGKKDQE PSHKKIKVDD GKTVESGIVE DDKKEDKFVF GAASKFGTGF GVAKKDTKDG 120
  121 DATTSTESLP ASDSKTKKPF AFGSGLSFGS GFNILKNKTE NNSESEKKAT DVDKDKVHSG 180
  181 SEQLANASED TKDKPKPLKL QKQEVKSGEE SEECIYQVNA KLYQLSNIKE GWKERGVGII 240
  241 KINKSKDDVE KTRIVMRSRG ILKVILNIQL VKGFTVQKGF TGSLQSEKFI RLLAVDDNGD 300
  301 PAQYAIKTGK KETTDELYNI IVKSVPK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ALA1 ARO1 DUG1 GDH1 HIS4 HIS6 HRD1 MET6 OYE2 RAD14 SCP160 SPE3 SPE4 TIM11 URA6 YLF2 YRB2
    View Details Ho Y, et al. (2002) CRM1 DIA4 PRS5 YDR131C YRB2

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data YRB2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..113] ORFEUS 7.87 No description for 1l8mA was found.
    2 View Details [114..189] ORFEUS 7.87 No description for 1l8mA was found.
    3 View Details [190..327] PSI-BLAST 105.39794 Nuclear pore complex protein Nup358

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  3.29080729281876 bayes_pls_golite062009
  • protein binding
    		•  2.12168271674167 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.10584700564436 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.85794418941003 bayes_pls_golite062009
  • DNA binding
    		•  1.77960272183811 bayes_pls_golite062009
  • transporter activity
    		•  1.28986800087234 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.15625292719687 bayes_pls_golite062009
  • signal transducer activity
    		•  1.15625292719687 bayes_pls_golite062009
  • Ran GTPase binding
    		•  1.07023555877478 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.79883446648737 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.74133713912741 bayes_pls_golite062009
  • actin binding
    		•  0.57235223545021 bayes_pls_golite062009
  • receptor activity
    		•  0.369903612832044 bayes_pls_golite062009
  • histone binding
    		•  0.359498460253937 bayes_pls_golite062009
  • protein domain specific binding
    		•  0.18356841109571 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.159652062741581 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0611639610381174 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0524559849408587 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.0498422520006935 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle