Protein Overview: PKP1

General Information:
Name(s) found:	PKP1 / YIL042C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|731802\|sp\|P40530.1\|PDK_YEAST RecName: Full=[Pyruvate dehydrogenase [lipoamide]] kinase, mitochondrial; Short=Pyruvate dehydrogenase kinase; AltName: Full=Protein kinase of PDH protein 1; Flags: Precursor [NCBI NR] gi\|6322147\|ref\|NP_012222.1\| Mitochondrial kinase, phosphorylates pyruvate dehydrogenase alpha subunit Pda1p; Pkp1p [Saccharomyces cerevisiae] [NCBI NR] gi\|600006\|emb\|CAA86909.1\| unknown [Saccharomyces cerevisiae] [NCBI NR] gi\|51012863\|gb\|AAT92725.1\| YIL042C [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S50696 hypothetical protein YIL042c - yeast (Saccharomyces cerevisiae) [NCBI NR] (P40530) Uncharacterized kinase YIL042C (EC 2.7.11.-) [Swiss-Prot] [Pyruvate dehydrogenase [lipoamide]] kinase, mitochondrial OS=Saccharomyces cerevisiae GN=PKP1 PE=1 SV=1 [Swiss-Prot] Putative mitochondrial kinase [mips] Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p [SGD] YIL042C, Chr IX from 275107-276291, reverse complement [yeast_orfs2] Chr IX from 275107-276291, reverse complement [yeastorf3.fasta] Chr IX from 276291-275107, reverse complement [yeastorf5.fasta] (P40530) Hypothetical 45.4 kDa protein in CBR5-NOT3 intergenic region [4932.FASTACCERV.txt] YIL042C SGDID:S0001304, Chr IX from 276291-275107, reverse complement, Uncharacterized ORF [yeastflysequest.fasta] Yil042cp [Saccharomyces cerevisiae]gi\|51012863\|gb\|AAT92725.1\| YIL042C [Saccharomyces cerevisiae]gi\|600006\|emb\|CAA86909.1\| unknown [Saccharomyces cerevisiae]gi\|731802\|sp\|P40530\|YIE2_YEAST Hypothetical 45.4 kDa protein in CBR5-NOT3 intergenic regiongi\|1 [nrdb_11152004_Chlamydomonas] YIL042C SGDID:S000001304, Chr IX from 276291-275107, reverse complement, Uncharacterized ORF, "Hypothetical protein" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] PKP1 SGDID:S000001304, Chr IX from 276291-275107, reverse complement, Verified ORF, "Mitochondrial kinase, phosphorylates pyruvate dehydrogenase alpha subunit Pda1p" [yeast-contam.fasta] PKP1 SGDID:S000001304, Chr IX from 276291-275107, reverse complement, Verified ORF, "Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] Mitochondrial kinase, phosphorylates pyruvate dehydrogenase alpha subunit Pda1p; Pkp1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] YIL042C [Saccharomyces cerevisiae] [nr-271106-contam.fasta] unknown [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Uncharacterized kinase YIL042C [nr-271106-contam.fasta] PKP1 SGDID:S000001304, Chr IX from 276291-275107, reverse complement, Verified ORF, "Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p" [yeast-bovrabprots.fasta] [chemostatdb.fasta] [Pyruvate dehydrogenase [lipoamide]] kinase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PKP1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] PKP1 SGDID:S000001304, Chr IX from 276292-275108, Genome Release 64-1-1, reverse complement, Verified ORF, "Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p" [yeast-030211-contam.fasta] [Pyruvate dehydrogenase (acetyl-transferring)] kinase 1, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PKP1 PE=1 SV=1 [YEAST.fasta.20131015] PKP1 SGDID:S000001304, Chr IX from 276292-275108, Genome Release 64-2-1, reverse complement, Verified ORF, "Mitochondrial protein kinase; involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p" [20141208_orf_trans.fasta] TR4390\|c0_g1_i1\|g.3089 ORF TR4390\|c0_g1_i1\|g.3089 TR4390\|c0_g1_i1\|m.3089 type:complete len:395 (+) TR4390\|c0_g1_i1:53-1237(+) [Y12_S_cerevisiae-Sep2015-contam.fasta] YIL042C SGDID:S000001304, Chr IX from 276292-275108, Genome Release 64-1-1, reverse complement, Verified ORF, "Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] asmbl_8735\|g.6567 ORF asmbl_8735\|g.6567 asmbl_8735\|m.6567 type:complete len:395 (+) asmbl_8735:62-1246(+) [Y12_Trinity_v2_2_0_PASA_6May2016-contam.fasta] ID=asmbl_8740\|g.5372 ORF ID=asmbl_8740\|g.5372 ID=asmbl_8740\|m.5372 type:complete len:395 (+) ID=asmbl_8740:62-1246(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	394 amino acids
Gene Ontology:
Cellular Component:	mitochondrion [IDA ][ISS]
Biological Process:	telomere maintenance [IMP] protein amino acid phosphorylation [IMP]
Molecular Function:	protein kinase activity [ISS] kinase activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MWKIMRSWKC GGMRWAHRQR PSHELLSQLS FDQHYKIRSN IELLIQDYAS KPIAPLNYEY  60
   61 FLQYRPPLTK KEEYMLTIKT INLLLSLTCK RLNAIQRLPY NAVINPHIER TNSLYLKSLQ 120
  121 TLLSIAYPYE LHNPPKIQAK FTELLDDHED AIVVLAKGLQ EIQSCYPKFQ ISQFLNFHLK 180
  181 ERITMKLLVT HYLSLMAQNK GDTNKRMIGI LHRDLPIAQL IKHVSDYVND ICFVKFNTQR 240
  241 TPVLIHPPSQ DITFTCIPPI LEYIMTEVFK NAFEAQIALG KEHMPIEINL LKPDDDELYL 300
  301 RIRDHGGGIT PEVEALMFNY SYSTHTQQSA DSESTDLPGE QINNVSGMGF GLPMCKTYLE 360
  361 LFGGKIDVQS LLGWGTDVYI KLKGPSKTAL LSKK

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	PKP1	Huh WK, et al. (2003)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..210]	PSI-BLAST	321.218487	Branched-chain alpha-ketoacid dehydrogenase kinase (BCK)
2	View Details	[211..394]	PSI-BLAST	321.218487	Branched-chain alpha-ketoacid dehydrogenase kinase (BCK)

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: PKP1

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: