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Protein Overview: YHB1

General Information:
Name(s) found: YHB1 / YGR234W [SGD]
Description(s) found:
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  • gi|88984161|sp|P39676.2|FHP_YEAST RecName: Full=Flavohemoprotein; AltName: Full=Flavohemoglobin; AltName: Full=Hemoglobin-like protein; AltName: Full=Nitric oxide dioxygenase; Short=NO oxygenase; Short=NOD [NCBI NR]
  • gi|886928|emb|CAA61184.1| ORF 399 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|6321673|ref|NP_011750.1| Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses; Yhb1p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|51013379|gb|AAT92983.1| YGR234W [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S57699 flavohemoglobin - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1323423|emb|CAA97262.1| YHB1 [Saccharomyces cerevisiae] [NCBI NR]
  • Flavohemoprotein OS=Saccharomyces cerevisiae GN=YHB1 PE=1 SV=2 [Swiss-Prot]
  • YHB1 Flavohemoglobin [mips]
  • Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses [SGD]
  • YHB1, Chr VII from 959898-961097 [yeast_orfs2]
  • Chr VII from 959898-961097 [yeastorf3.fasta]
  • Chr VII from 959905-961104 [yeastorf4.fasta]
  • YHB1 SGDID:S0003466, Chr VII from 959906-961105, Verified ORF [yeastflysequest.fasta]
  • YHB1 SGDID:S0003466, Chr VII from 959907-961106, Verified ORF [10112005cervSGD.fasta]
  • Yhb1p [Saccharomyces cerevisiae]gi|51013379|gb|AAT92983.1| YGR234W [Saccharomyces cerevisiae]gi|886928|emb|CAA61184.1| ORF 399 [Saccharomyces cerevisiae]gi|1323423|emb|CAA97262.1| YHB1 [Saccharomyces cerevisiae]gi|1362285|pir||S57699 flavohemoglobin - [nrdb_11152004_Chlamydomonas]
  • (Q6B1W6) YGR234W [cerv4932.FASTAC]
  • YHB1 SGDID:S000003466, Chr VII from 959908-961107, Verified ORF, "Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Flavohemoprotein (Hemoglobin-like protein) (Flavohemoglobin) (Nitric oxide dioxygenase) (NO oxygenase) (NOD) [nr-271106-contam.fasta]
  • ORF 399 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses; Yhb1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • YGR234W [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • YHB1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Flavohemoprotein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YHB1 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • YHB1 SGDID:S000003466, Chr VII from 959904-961103, Genome Release 64-1-1, Verified ORF, "Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses" [yeast-030211-contam.fasta]
  • YHB1 SGDID:S000003466, Chr VII from 959904-961103, Genome Release 64-2-1, Verified ORF, "Nitric oxide oxidoreductase; flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress" [20141208_orf_trans.fasta]
  • YGR234W SGDID:S000003466, Chr VII from 959904-961103, Genome Release 64-1-1, Verified ORF, "Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 399 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    mitochondrial matrix [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: response to stress [IDALink to PubMed articleLink to PubMed article]
    Molecular Function: nitric oxide reductase activity [IMPLink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLAEKTRSII KATVPVLEQQ GTVITRTFYK NMLTEHTELL NIFNRTNQKV GAQPNALATT  60
   61 VLAAAKNIDD LSVLMDHVKQ IGHKHRALQI KPEHYPIVGE YLLKAIKEVL GDAATPEIIN 120
  121 AWGEAYQAIA DIFITVEKKM YEEALWPGWK PFDITAKEYV ASDIVEFTVK PKFGSGIELE 180
  181 SLPITPGQYI TVNTHPIRQE NQYDALRHYS LCSASTKNGL RFAVKMEAAR ENFPAGLVSE 240
  241 YLHKDAKVGD EIKLSAPAGD FAINKELIHQ NEVPLVLLSS GVGVTPLLAM LEEQVKCNPN 300
  301 RPIYWIQSSY DEKTQAFKKH VDELLAECAN VDKIIVHTDT EPLINAAFLK EKSPAHADVY 360
  361 TCGSLAFMQA MIGHLKELEH RDDMIHYEPF GPKMSTVQV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CCT8 MKT1 YHB1
    View Details Gavin AC, et al. (2006) ACO1 ARO1 MDH1 RAD51 SSE1 YHB1
    View Details Gavin AC, et al. (2002) ARO1 ASC1 CCT8 CHC1 CLC1 CLU1 CPA2 GCN1 GCN20 GFA1 GUS1 HHF1, HHF2 HSC82 IDH2 ILV1 IRR1 KAP123 LYS12 MCD1 MKT1 NOP12 PFK1 RAD51 RAD52 RFA1 RPA135 RPB2 RPN9 RPT3 RPT6 RVB2 SCC4 SMC1 SMC3 TSA1 YHB1
    View Details Ho Y, et al. (2002) ADH2 ADK1 ADO1 AGX1 CDC16 CDC33 CNS1 DUG2 ECM10 EFB1 ERB1 FPR3 HHF1, HHF2 ILV5 INP52 KRE33 KRI1 LOC1 MES1 MKT1 MMS4 MUS81 NHP2 NOP12 NOP2 PCL7 PHO81 PHO85 PWP1 RAD53 RNH202 RNQ1 RPC10 RPF2 SAP190 SEC23 SEC53 TAF14 TEM1 TIF1, TIF2 UBI4 UTP22 VMA5 YHB1 YRA1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run TOR1 No Comments Reinke A, et al. (2004)
    View Run TOR2 No Comments Reinke A, et al. (2004)
    View Run LST8 No Comments Reinke A, et al. (2004)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi1 with gst from october 2005 McCusker D, et al (2007)
    View Run MLP2 #19 Asynchronous Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #27 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps3-5 Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)
    View Run MLP2 #04 Alpha Factor Prep2 Keck JM, et al. (2011)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #08 Alpha Factor Prep4-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #19b Asynchronous Prep1-new search criteria Keck JM, et al. (2011)
    View Run MLP2 #19a Asynchronous Prep1-new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data YHB1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..72]
    [94..131]    		 PSI-BLAST 711.512579 Flavohemoglobin, N-terminal domain; Flavohemoglobin, central domain; Flavohemoglobin, C-terminal domain
    2 View Details [73..93]
    [132..260]    		 PSI-BLAST 711.512579 Flavohemoglobin, N-terminal domain; Flavohemoglobin, central domain; Flavohemoglobin, C-terminal domain
    3 View Details [261..399] PSI-BLAST 711.512579 Flavohemoglobin, N-terminal domain; Flavohemoglobin, central domain; Flavohemoglobin, C-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxygen transporter activity
    		•  7.81281381234264 bayes_pls_golite062009
  • oxygen binding
    		•  3.78522064312431 bayes_pls_golite062009
  • hemoglobin binding
    		•  3.17505496298935 bayes_pls_golite062009
  • transporter activity
    		•  2.77225108027137 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.44807175467553 bayes_pls_golite062009
  • binding
    		•  1.56341797572673 bayes_pls_golite062009
  • catalytic activity
    		•  1.45374095556065 bayes_pls_golite062009
  • hemoglobin alpha binding
    		•  1.07662870695556 bayes_pls_golite062009
  • nitric-oxide synthase activity
    		•  0.943011064240739 bayes_pls_golite062009
  • transferase activity
    		•  0.708491789248912 bayes_pls_golite062009
  • riboflavin synthase activity
    		•  0.366634814975673 bayes_pls_golite062009
  • cofactor binding
    		•  0.365255270036622 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.27336340260908 bayes_pls_golite062009
  • coenzyme binding
    		•  0.270924422726986 bayes_pls_golite062009
  • protein binding
    		•  0.144900113694048 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle