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Protein Overview: MDJ1

General Information:
Name(s) found: MDJ1 / YFL016C [SGD]
Description(s) found:
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  • gi|836738|dbj|BAA09222.1| MDJ1 protein precursor [Saccharomyces cerevisiae] [NCBI NR]
  • gi|559936|emb|CAA86351.1| mdj1 [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S38898 heat shock protein MDJ1 precursor - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|462580|sp|P35191.1|MDJ1_YEAST RecName: Full=DnaJ homolog 1, mitochondrial; Flags: Precursor [NCBI NR]
  • gi|431910|emb|CAA82189.1| Mdj1p heat shock protein [Saccharomyces cerevisiae] [NCBI NR]
  • gi|14318504|ref|NP_116638.1| Protein involved in folding of mitochondrially synthesized proteins in the mitochondrial matrix; localizes to the mitochondrial inner membrane; member of the DnaJ family of molecular chaperones; Mdj1p [Saccharomyces cerevisiae [NCBI NR]
  • DnaJ homolog 1, mitochondrial OS=Saccharomyces cerevisiae GN=MDJ1 PE=1 SV=1 [Swiss-Prot]
  • MDJ1 Heat shock protein - chaperone [mips]
  • Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones [SGD]
  • MDJ1, Chr VI from 104695-106230, reverse complement [yeast_orfs2]
  • Chr VI from 104695-106230, reverse complement [yeastorf3.fasta]
  • Chr VI from 106230-104695, reverse complement [yeastorf5.fasta]
  • (P35191) MDJ1 protein, mitochondrial precursor [4932.FASTACCERV.txt]
  • MDJ1 SGDID:S0001878, Chr VI from 106230-104695, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Mdj1p [Saccharomyces cerevisiae]gi|559936|emb|CAA86351.1| mdj1 [Saccharomyces cerevisiae]gi|431910|emb|CAA82189.1| Mdj1p heat shock protein [Saccharomyces cerevisiae]gi|462580|sp|P35191|MDJ1_YEAST MDJ1 protein, mitochondrial precursorgi|481583|pir||S3 [nrdb_11152004_Chlamydomonas]
  • MDJ1 SGDID:S000001878, Chr VI from 106230-104695, reverse complement, Verified ORF, "Protein involved in folding of mitochondrially synthesized proteins in the mitochondrial matrix; localizes to the mitochondrial inner membrane; member of the DnaJ family [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • MDJ1 SGDID:S000001878, Chr VI from 106230-104695, reverse complement, Verified ORF, "Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • Mdj1p heat shock protein [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • mdj1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • MDJ1 protein precursor [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Protein involved in folding of mitochondrially synthesized proteins in the mitochondrial matrix; localizes to the mitochondrial inner membrane; member of the DnaJ family of molecular chaperones; Mdj1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • DnaJ homolog 1, mitochondrial precursor [nr-271106-contam.fasta]
  • MDJ1 SGDID:S000001878, Chr VI from 106230-104695, reverse complement, Verified ORF, "Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones" [yeast-bovrabprots.fasta]
  • MDJ1 SGDID:S000001878, Chr VI from 106230-104695, reverse complement, Verified ORF, "Protein involved in folding of mitochondrially synthesized proteins in the mitochondrial matrix; localizes to the mitochondrial inner membrane; member of the DnaJ family of molecular chaperones" [yeast-contam_custom.fasta]
  • [chemostatdb.fasta]
  • DnaJ homolog 1, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MDJ1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • MDJ1 SGDID:S000001878, Chr VI from 106236-104701, Genome Release 64-1-1, reverse complement, Verified ORF, "Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones" [yeast-030211-contam.fasta]
  • MDJ1 SGDID:S000001878, Chr VI from 106236-104701, Genome Release 64-2-1, reverse complement, Verified ORF, "Co-chaperone that stimulates HSP70 protein Ssc1p ATPase activity; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones" [20141208_orf_trans.fasta]
  • YFL016C SGDID:S000001878, Chr VI from 106236-104701, Genome Release 64-1-1, reverse complement, Verified ORF, "Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 511 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed article]
    mitochondrial inner membrane [IDALink to PubMed article]
    Biological Process: proteolysis [IMPLink to PubMed article]
    protein folding [IDALink to PubMed article]
    Molecular Function: chaperone binding [IMPLink to PubMed article]
    unfolded protein binding [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAFQQGVLSR CSGVFRHHVG HSRHINNILY RHAIAFASIA PRIPKSSFHT SAIRNNEAFK  60
   61 DPYDTLGLKK SATGAEIKKA YYKLAKKYHP DINKEPDAEK KFHDLQNAYE ILSDETKRQQ 120
  121 YDQFGPAAFG GGGAAGGAGG GSGSPFGSQF HDFSGFTSAG GSPFGGINFE DLFGAAFGGG 180
  181 GRGSGGASRS SSMFRQYRGD PIEIVHKVSF KDAVFGSKNV QLRFSALDPC STCSGTGMKP 240
  241 NTHKVSCSTC HGTGTTVHIR GGFQMMSTCP TCNGEGTMKR PQDNCTKCHG EGVQVNRAKT 300
  301 ITVDLPHGLQ DGDVVRIPGQ GSYPDIAVEA DLKDSVKLSR GDILVRIRVD KDPNFSIKNK 360
  361 YDIWYDKEIP ITTAALGGTV TIPTVEGQKI RIKVAPGTQY NQVISIPNMG VPKTSTIRGD 420
  421 MKVQYKIVVK KPQSLAEKCL WEALADVTND DMAKKTMQPG TAAGTAINEE ILKKQKQEEE 480
  481 KHAKKDDDNT LKRLENFITN TFRKIKGDKK N

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) MDJ1 RPL11B
    View Details Krogan NJ, et al. (2006) MDJ1 SCC2 SCC4
    View Details Ho Y, et al. (2002) ACC1 CCT6 CDC33 CPR6 DMC1 DPM1 FMP10 MDJ1 MTC5 NOP14 NPR2 POX1 RNQ1 RVB2 SEH1 THI21 TRP3 YHR033W
    View Details Qiu et al. (2008) HSP78 MDJ1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run TOR2 No Comments Reinke A, et al. (2004)
    View Run MIA40 No Comments Hazbun TR, et al. (2003)
    View Run LST8 No Comments Reinke A, et al. (2004)
    View Run TOR2 No Comments Reinke A, et al. (2004)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run BOI1 Sample bob1 (2nd set) from october 2005 McCusker D, et al (2007)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data MDJ1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..180] PSI-BLAST 169.0 DnaJ chaperone, N-terminal (J) domain
    2 View Details [181..296] PSI-BLAST 142.64593 Cysteine-rich domain of the chaperone protein DnaJ.
    3 View Details [297..511] PSI-BLAST 22.30103 Heat shock protein 40 Sis1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • unfolded protein binding
    		•  3.04403163860617 bayes_pls_golite062009
  • chaperone binding
    		•  2.86745334638583 bayes_pls_golite062009
  • protein binding
    		•  2.65982681685488 bayes_pls_golite062009
  • binding
    		•  2.63138872417193 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.31739509739943 bayes_pls_golite062009
  • heat shock protein binding
    		•  2.17994194200939 bayes_pls_golite062009
  • DNA binding
    		•  1.88444505115207 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.73387701301727 bayes_pls_golite062009
  • transporter activity
    		•  1.29863098651348 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.927337691912581 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.812144232432417 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.675735261884317 bayes_pls_golite062009
  • protein transporter activity
    		•  0.599800483479766 bayes_pls_golite062009
  • Hsp70 protein binding
    		•  0.541755903922701 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.130185025729857 bayes_pls_golite062009
  • catalytic activity
    		•  0.106988907594358 bayes_pls_golite062009
    2
    Term Confidence Notes
  • binding
    		•  2.7298921704023 bayes_pls_golite062009
  • protein binding
    		•  2.6297172985864 bayes_pls_golite062009
  • unfolded protein binding
    		•  2.04158808514315 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.594882036388263 bayes_pls_golite062009
  • receptor binding
    		•  0.395342079633271 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.301226589648736 bayes_pls_golite062009
  • protein disulfide isomerase activity
    		•  0.290861970307477 bayes_pls_golite062009
  • intramolecular oxidoreductase activity, transposing S-S bonds
    		•  0.290861970307477 bayes_pls_golite062009
  • catalytic activity
    		•  0.276917867171685 bayes_pls_golite062009
  • intramolecular oxidoreductase activity, interconverting keto- and enol-groups
    		•  0.0964866497718595 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.68

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle