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Protein Overview: MET6

General Information:
Name(s) found: MET6 / YER091C [SGD]
Description(s) found:
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  • gi|976441|gb|AAB60301.1| N5-methyltetrahydrofolate homocysteine methyltransferase [NCBI NR]
  • gi|88910025|gb|ABD57966.1| methionine synthase [Saccharomyces cerevisiae] [NCBI NR]
  • gi|88910023|gb|ABD57965.1| methionine synthase [Saccharomyces cerevisiae] [NCBI NR]
  • gi|730018|sp|P05694.4|METE_YEAST RecName: Full=5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; AltName: Full=Methionine synthase, vitamin-B12 independent isozyme; AltName: Full=Cobalamin-independent methionine synthase; AltName: Ful [NCBI NR]
  • gi|6320936|ref|NP_011015.1| Cobalamin-independent methionine synthase, involved in amino acid biosynthesis; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs; Met6p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|603329|gb|AAB64646.1| Met6p: 5-methyltetrahydropteroyl triglutamate--homocysteine methyltransferase [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S50594 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase (EC 2.1.1.14) - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase OS=Saccharomyces cerevisiae GN=MET6 PE=1 SV=4 [Swiss-Prot]
  • MET6 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase [mips]
  • Cobalamin-independent methionine synthase, involved in methionine biosynthesis and regeneration; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs [SGD]
  • MET6, Chr V from 339860-342163, reverse complement [yeast_orfs2]
  • Chr V from 339860-342163, reverse complement [yeastorf3.fasta]
  • Chr V from 342163-339860, reverse complement [yeastorf5.fasta]
  • MET6 SGDID:S0000893, Chr V from 342163-339860, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Cobalamin-independent methionine synthase, involved in amino acid biosynthesis; also called N5-methyltetrahydrofolate homocysteine methyltransferase or 5-methyltetrahydropteroyltriglutamate homocysteine methyltransferase [Saccharomyces cerevisiae]gi|7300 [nrdb_11152004_Chlamydomonas]
  • MET6 SGDID:S000000893, Chr V from 342163-339860, reverse complement, Verified ORF, "Cobalamin-independent methionine synthase, involved in amino acid biosynthesis; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to ba [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • MET6 SGDID:S000000893, Chr V from 342163-339860, reverse complement, Verified ORF, "Cobalamin-independent methionine synthase, involved in methionine biosynthesis and regeneration; requires a minimum of two glutamates on the methyltetrahydrofolate substra [SGD_S-cerevisiae_na_05-08-2009_con_reversed.fasta]
  • methionine synthase [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Met6p: 5-methyltetrahydropteroyl triglutamate--homocysteine methyltransferase [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (Methionine synthase, vitamin-B12 independent isozyme) (Cobalamin-independent methionine synthase) (Delta-P8 protein) [nr-271106-contam.fasta]
  • Cobalamin-independent methionine synthase, involved in amino acid biosynthesis; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs; Met6p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • N5-methyltetrahydrofolate homocysteine methyltransferase [nr-271106-contam.fasta]
  • MET6 SGDID:S000000893, Chr V from 342163-339860, reverse complement, Verified ORF, "Cobalamin-independent methionine synthase, involved in amino acid biosynthesis; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs" [yeast-bovrabprots.fasta]
  • MET6 SGDID:S000000893, Chr V from 342163-339860, reverse complement, Verified ORF, "Cobalamin-independent methionine synthase, involved in methionine biosynthesis and regeneration; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs" [scerevisihumanrev.fasta]
  • [chemostatdb.fasta]
  • 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MET6 PE=1 SV=4 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • MET6 SGDID:S000000893, Chr V from 342167-339864, Genome Release 64-1-1, reverse complement, Verified ORF, "Cobalamin-independent methionine synthase, involved in methionine biosynthesis and regeneration; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs" [yeast-030211-contam.fasta]
  • MET6 SGDID:S000000893, Chr V from 342167-339864, Genome Release 64-2-1, reverse complement, Verified ORF, "Cobalamin-independent methionine synthase; involved in methionine biosynthesis and regeneration; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs" [20141208_orf_trans.fasta]
  • YER091C SGDID:S000000893, Chr V from 342167-339864, Genome Release 64-1-1, reverse complement, Verified ORF, "Cobalamin-independent methionine synthase, involved in methionine biosynthesis and regeneration; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 767 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: methionine biosynthetic process [IMPLink to PubMed article]
    Molecular Function: 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVQSAVLGFP RIGPNRELKK ATEGYWNGKI TVDELFKVGK DLRTQNWKLQ KEAGVDIIPS  60
   61 NDFSFYDQVL DLSLLFNVIP DRYTKYDLSP IDTLFAMGRG LQRKATETEK AVDVTALEMV 120
  121 KWFDSNYHYV RPTFSKTTQF KLNGQKPVDE FLEAKELGIH TRPVLLGPVS YLFLGKADKD 180
  181 SLDLEPLSLL EQLLPLYTEI LSKLASAGAT EVQIDEPVLV LDLPANAQAA IKKAYTYFGE 240
  241 QSNLPKITLA TYFGTVVPNL DAIKGLPVAA LHVDFVRAPE QFDEVVAAIG NKQTLSVGIV 300
  301 DGRNIWKNDF KKSSAIVNKA IEKLGADRVV VATSSSLLHT PVDLNNETKL DAEIKGFFSF 360
  361 ATQKLDEVVV ITKNVSGQDV AAALEANAKS VESRGKSKFI HDAAVKARVA SIDEKMSTRA 420
  421 APFEQRLPEQ QKVFNLPLFP TTTIGSFPQT KDIRINRNKF NKGTISAEEY EKFINSEIEK 480
  481 VIRFQEEIGL DVLVHGEPER NDMVQYFGEQ INGYAFTVNG WVQSYGSRYV RPPIIVGDLS 540
  541 RPKAMSVKES VYAQSITSKP VKGMLTGPIT CLRWSFPRDD VDQKTQAMQL ALALRDEVND 600
  601 LEAAGIKVIQ VDEPALREGL PLREGTERSA YYTWAAEAFR VATSGVANKT QIHSHFCYSD 660
  661 LDPNHIKALD ADVVSIEFSK KDDANYIAEF KNYPNHIGLG LFDIHSPRIP SKDEFIAKIS 720
  721 TILKSYPAEK FWVNPDCGLK TRGWEETRLS LTHMVEAAKY FREQYKN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ALA1 ARO1 DUG1 GDH1 HIS4 HIS6 HRD1 MET6 OYE2 RAD14 SCP160 SPE3 SPE4 TIM11 URA6 YLF2 YRB2
    View Details Gavin AC, et al. (2006) MET6 TKL1
    View Details Ho Y, et al. (2002) AAT2 ACH1 ACO1 AFR1 AHP1 ARC1 ARF1 ATP3 CAR2 CCT6 CDC12 CDC14 CDC33 CLU1 COF1 COR1 CPR1 CYR1 CYS4 DOG1 DOG2 EGD1 EGD2 ERB1 ERG13 ERG6 FPR1 FRS2 GND1 GND2 GRX1 GUS1 HAS1 HEF3 HHF1, HHF2 HXT7 IMD4 LRO1 LSP1 MET6 MRT4 MSK1 MUB1 NOC2 NOC3 NOG1 NSA1 NTF2 NUG1 OLA1 OYE2 PFK1 PIL1 PRM2 PRP43 PYC1 RGD1 RNR2 RSN1 SAH1 SCP160 SCS2 SEC53 SEN15 SES1 SNU13 SOD1 SPB4 SSQ1 TEF4 THS1 TIF1, TIF2 TIF6 TMA19 TSA2 UBA1 UBR2 VMA22 VMA4 VMA5 WTM1 YNK1 YTM1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run PGA1 No Comments Hazbun TR, et al. (2003)
    View Run KOG1 No Comments Reinke A, et al. (2004)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #04 Alpha Factor Prep2 Keck JM, et al. (2011)
    View Run MLP2 #14 Mitotic Prep2-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data MET6 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..104] MSA 1.042975 View MSA. No confident structure predictions are available.
    2 View Details [105..401] deduced N/A No confident structure predictions are available.
    3 View Details [402..440]
    [674..767]    		 ORFEUS 11.96 Uroporphyrinogen decarboxylase, UROD
    4 View Details [441..673] ORFEUS 11.96 Uroporphyrinogen decarboxylase, UROD

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity
    		•  6.40786073037099 bayes_pls_golite062009
  • 5-methyltetrahydropteroyltri-L-glutamate-dependent methyltransferase activity
    		•  6.40786073037099 bayes_pls_golite062009
  • uroporphyrinogen decarboxylase activity
    		•  3.13638443707338 bayes_pls_golite062009
  • S-methyltransferase activity
    		•  3.0142199413027 bayes_pls_golite062009
  • catalytic activity
    		•  2.37862248560593 bayes_pls_golite062009
  • binding
    		•  1.590130518929 bayes_pls_golite062009
  • carbon-carbon lyase activity
    		•  1.54242506764415 bayes_pls_golite062009
  • carboxy-lyase activity
    		•  1.52150758949987 bayes_pls_golite062009
  • lyase activity
    		•  0.825209465219608 bayes_pls_golite062009
  • protein binding
    		•  0.21865699924356 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle