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Protein Overview: VCX1

General Information:
Name(s) found: VCX1 / YDL128W [SGD]
Description(s) found:
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  • gi|74623660|sp|Q99385.1|VCX1_YEAST RecName: Full=Vacuolar calcium ion transporter; AltName: Full=Vacuolar Ca(2+)/H(+) exchanger; AltName: Full=High copy number undoes manganese protein 1; AltName: Full=Manganese resistance 1 protein [NCBI NR]
  • gi|6320075|ref|NP_010155.1| Vacuolar H+/Ca2+ exchanger involved in control of cytosolic Ca2+ concentration; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter; Vcx1p [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S61933 Ca2+/H+-exchanging protein, vacuolar - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1431193|emb|CAA98696.1| VCX1 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1173485|gb|AAC49550.1| Hum1p [NCBI NR]
  • gi|1139591|gb|AAB60313.1| vacuolar H+/Ca2+ exchanger [NCBI NR]
  • Vacuolar calcium ion transporter OS=Saccharomyces cerevisiae GN=VCX1 PE=1 SV=1 [Swiss-Prot]
  • VCX1 Vacuolar Ca++/H+ exchanger [mips]
  • Vacuolar H+/Ca2+ exchanger involved in control of cytosolic Ca2+ concentration; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter [SGD]
  • VCX1, Chr IV from 232652-233887 [yeast_orfs2]
  • Chr IV from 232652-233887 [yeastorf3.fasta]
  • >Q99385 (Q99385) Chromosome IV reading frame ORF YDL128W [4932.FASTACCERV.txt]
  • VCX1 SGDID:S0002286, Chr IV from 232652-233887, Verified ORF [yeastflysequest.fasta]
  • Vacuolar H+/Ca2+ exchanger, has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter [Saccharomyces cerevisiae]gi|1431193|emb|CAA98696.1| VCX1 [Saccharomyces cerevisiae]gi|1173485|gb|AAC49550.1| Hum1pgi|1139591|gb|AAB603 [nrdb_11152004_Chlamydomonas]
  • (Q99385) VCX1 protein (Hum1p) (Vacuolar H+/Ca2+ exchanger) [cerv4932.FASTAC]
  • VCX1 SGDID:S000002286, Chr IV from 232652-233887, Verified ORF, "Vacuolar H+/Ca2+ exchanger involved in control of cytosolic Ca2+ concentration; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • vacuolar H+/Ca2+ exchanger [nr-271106-contam.fasta]
  • Vacuolar calcium ion transporter (Vacuolar Ca(2+)/H(+) exchanger) (High copy number undoes manganese protein 1) (Manganese resistance 1 protein) [nr-271106-contam.fasta]
  • Hum1p [nr-271106-contam.fasta]
  • Vacuolar H+/Ca2+ exchanger involved in control of cytosolic Ca2+ concentration; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter; Vcx1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • VCX1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Vacuolar calcium ion transporter OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=VCX1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • VCX1 SGDID:S000002286, Chr IV from 232652-233887, Genome Release 64-1-1, Verified ORF, "Vacuolar membrane antiporter with Ca2+/H+ and K+/H+ exchange activity, involved in control of cytosolic Ca2+ and K+ concentrations; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter" [yeast-030211-contam.fasta]
  • VCX1 SGDID:S000002286, Chr IV from 232652-233887, Genome Release 64-2-1, Verified ORF, "Vacuolar membrane antiporter with Ca2+/H+ and K+/H+ exchange activity; involved in control of cytosolic Ca2+ and K+ concentrations; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter" [20141208_orf_trans.fasta]
  • TR8009|c0_g1_i1|g.5558 ORF TR8009|c0_g1_i1|g.5558 TR8009|c0_g1_i1|m.5558 type:complete len:412 (+) TR8009|c0_g1_i1:128-1363(+) [Y12_S_cerevisiae-Sep2015-contam.fasta]
  • YDL128W SGDID:S000002286, Chr IV from 232652-233887, Genome Release 64-1-1, Verified ORF, "Vacuolar membrane antiporter with Ca2+/H+ and K+/H+ exchange activity, involved in control of cytosolic Ca2+ and K+ concentrations; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
  • asmbl_693|g.85 ORF asmbl_693|g.85 asmbl_693|m.85 type:complete len:412 (+) asmbl_693:117-1352(+) [Y12_Trinity_v2_2_0_PASA_6May2016-contam.fasta]
  • ID=asmbl_697|g.114 ORF ID=asmbl_697|g.114 ID=asmbl_697|m.114 type:complete len:412 (+) ID=asmbl_697:117-1352(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 411 amino acids

    Gene Ontology:
    Cellular Component: fungal-type vacuole [IDALink to PubMed article]
    Biological Process: [NOT]manganese ion transport [IDALink to PubMed article]
    calcium ion transport [IDALink to PubMed article][IMPLink to PubMed article]
    cellular calcium ion homeostasis [IMPLink to PubMed article]
    Molecular Function: calcium ion transmembrane transporter activity [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDATTPLLTV ANSHPARNPK HTAWRAAVYD LQYILKASPL NFLLVFVPLG LIWGHFQLSH  60
   61 TLTFLFNFLA IIPLAAILAN ATEELADKAG NTIGGLLNAT FGNAVELIVS IIALKKGQVR 120
  121 IVQASMLGSL LSNLLLVLGL CFIFGGYNRV QQTFNQTAAQ TMSSLLAIAC ASLLIPAAFR 180
  181 ATLPHGKEDH FIDGKILELS RGTSIVILIV YVLFLYFQLG SHHALFEQQE EETDEVMSTI 240
  241 SRNPHHSLSV KSSLVILLGT TVIISFCADF LVGTIDNVVE STGLSKTFIG LIVIPIVGNA 300
  301 AEHVTSVLVA MKDKMDLALG VAIGSSLQVA LFVTPFMVLV GWMIDVPMTL NFSTFETATL 360
  361 FIAVFLSNYL ILDGESNWLE GVMSLAMYIL IAMAFFYYPD EKTLDSIGNS L

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) BPT1 CCC1 COT1 CTR2 PMC1 SMF3 VCX1 VMA9

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data VCX1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..238] MSA 17.095982 View MSA. No confident structure predictions are available.
    2 View Details [239..411] Pfam 3.677781 Sodium/calcium exchanger protein No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle