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Protein Overview: CYK3

General Information:
Name(s) found: CYK3 / YDL117W [SGD]
Description(s) found:
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  • gi|6320086|ref|NP_010166.1| SH3-domain protein located in the mother-bud neck and the cytokinetic actin ring; mutant phenotype and genetic interactions suggest a role in cytokinesis; Cyk3p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|55976291|sp|Q07533.1|CYK3_YEAST RecName: Full=Cytokinesis protein 3 [NCBI NR]
  • pir||S67660 hypothetical protein YDL117w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1431172|emb|CAA98685.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • Cytokinesis protein 3 OS=Saccharomyces cerevisiae GN=CYK3 PE=1 SV=1 [Swiss-Prot]
  • CYK3 SH3-domain protein located in the mother-bud neck and the cytokinetic actin ring, possibly involved in cytokinesis [mips]
  • SH3-domain protein located in the mother-bud neck and the cytokinetic actin ring; mutant phenotype and genetic interactions suggest a role in cytokinesis [SGD]
  • CYK3, Chr IV from 248580-251237 [yeast_orfs2]
  • Chr IV from 248580-251237 [yeastorf3.fasta]
  • >Q07533 (Q07533) Chromosome IV reading frame ORF YDL117W [4932.FASTACCERV.txt]
  • CYK3 SGDID:S0002275, Chr IV from 248581-251238, Verified ORF [yeastflysequest.fasta]
  • Cyk3p [Saccharomyces cerevisiae]gi|1431172|emb|CAA98685.1| unnamed protein product [Saccharomyces cerevisiae]gi|2131339|pir||S67660 hypothetical protein YDL117w - yeast (Saccharomyces cerevisiae) [nrdb_11152004_Chlamydomonas]
  • (Q07533) S.cerevisiae chromosome IV reading frame ORF YDL117w [cerv4932.FASTAC]
  • CYK3 SGDID:S000002275, Chr IV from 248581-251238, Verified ORF, "SH3-domain protein located in the mother-bud neck and the cytokinetic actin ring; mutant phenotype and genetic interactions suggest a role in cytokinesis" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Cytokinesis protein 3 [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • SH3-domain protein located in the mother-bud neck and the cytokinetic actin ring; mutant phenotype and genetic interactions suggest a role in cytokinesis; Cyk3p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Cytokinesis protein 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CYK3 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • CYK3 SGDID:S000002275, Chr IV from 248581-251238, Genome Release 64-1-1, Verified ORF, "SH3-domain protein located in the mother-bud neck and the cytokinetic actin ring; mutant phenotype and genetic interactions suggest a role in cytokinesis" [yeast-030211-contam.fasta]
  • CYK3 SGDID:S000002275, Chr IV from 248581-251238, Genome Release 64-2-1, Verified ORF, "SH3-domain protein located in the bud neck and cytokinetic actin ring; relocalizes from bud neck to nucleus upon DNA replication stress; activates the chitin synthase activity of Chs2p during cytokinesis; suppressor of growth and cytokinesis defects of chs2 phospho-mutants" [20141208_orf_trans.fasta]
  • YDL117W SGDID:S000002275, Chr IV from 248581-251238, Genome Release 64-1-1, Verified ORF, "SH3-domain protein located in the mother-bud neck and the cytokinetic actin ring; mutant phenotype and genetic interactions suggest a role in cytokinesis" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 885 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    cellular bud neck [IDALink to PubMed article]
    Biological Process: cytokinesis [IGILink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATNLTSLKP PFKVKARYGW SGQTKGDLGF LEGDIMEVTR IAGSWFYGKL LRNKKCSGYF  60
   61 PHNFVILLEE RLNSSTENGR QPSKIVESFE KSNKVVIPPV PSRYSDERPR PKKKLSSSMP 120
  121 NSPKKPVDSL TKARKAKSKE MVNEKNIYNT QSSRHHNNSA PNLPLASHSK PQVRNFEESM 180
  181 NNPLPPLPPL PDLDNMRKTD KRAPKKSYSA NDLHMARSSR EYNYYKDNQK FYDGFIPEKR 240
  241 YSLEEDSISS GLFSNSQYLN DSACSSENSF ALMSDFSATS AGSFARHKYA QSFSDSLQRS 300
  301 QNANGCSTKI NDSQEFGDSN ASSRNGKMGD ILRKIIIPKR NTNIYSSSVS SPKSPKAYPK 360
  361 LPDIQNLNLS ATPDEARDWI AVKCHLNRAR TLTKYDKHPR YMRALEENRD LILHPQDSIY 420
  421 NGLNTNEVKG NTKPGLVDVE LAELNIEYID KMTWKRCIRD GTMTLDSWAQ TTFSARYSTV 480
  481 LEKLRGIYIF CTEMFALTDD NGTSDFSAEP QNLEKILYRK HCTPYELTWL FKKLANSLGI 540
  541 TCEIVIGFLK TPSAINWEFK YNHCWLRILV NKEWRFIDVI LGNVTNPIHE FVNNRKIKKA 600
  601 ENSYFLMAPL EMIYTHIPPR EFEQHIVPSI DQLSALYLPL VFPSFFKNEL KLYKFSTALS 660
  661 FLEDSEIYEC SLEIPNDVEV FASVVIPTDN EEASSAYRNM ELALTQIKKQ KAESGRRIAL 720
  721 IKAVLPPNVN KGSLYIHSGV RGTQTSIANI HPLSMMVPLT HKGSNMKYEF VIKIPSESIQ 780
  781 KIELYIVEPQ SRYLFVGNEY SFEVIQSPSD GIVYSSDEGP NQNRKQPMAI KSPSGRVHEL 840
  841 VKSDPHFPYG TWKGSIKIKE PGVWSALVIA DSGIGWSVFA EWLCV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CYK3 FOX2
    View Details Ho Y, et al. (2002) ADR1 BMH1 BNR1 BOI2 CSR2 CYK3 GSY2 KCS1 NTH1 REG1 SOK1 STU1 SVL3 YFR017C YIL028W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run VAM3 Sample: HX11 - both fusion and trans-SNARE complex formation take place. Hao Xu, et al. (2010)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CYK3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..90] PSI-BLAST 5.69897 Carboxyl-terminal src kinase (csk)
    2 View Details [91..459] MSA 28.488997 View MSA. No confident structure predictions are available.
    3 View Details [460..621] ORFEUS 8.13 Arylamine N-acetyltransferase
    4 View Details [622..885] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • hydrolase activity
    		•  0.895753300445801 bayes_pls_golite062009
  • catalytic activity
    		•  0.452849626127585 bayes_pls_golite062009
  • binding
    		•  0.139322852139959 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle