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Protein Overview: PGK1

General Information:
Name(s) found: PGK1 / YCR012W [SGD]
Description(s) found:
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  • gi|14588927|emb|CAA42329.2| phosphoglycerate kinase [Saccharomyces cerevisiae] [NCBI NR]
  • gi|129930|sp|P00560.2|PGK_YEAST RecName: Full=Phosphoglycerate kinase [NCBI NR]
  • gi|1197055|gb|AAA88729.1| 3-phosphoglycerate kinase [Saccharomyces cerevisiae] [NCBI NR]
  • gi|10383781|ref|NP_009938.2| 3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis; Pgk1p [Saccharomyces cerevi [NCBI NR]
  • Phosphoglycerate kinase OS=Saccharomyces cerevisiae GN=PGK1 PE=1 SV=2 [Swiss-Prot]
  • PGK1 Phosphoglycerate kinase [mips]
  • 3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis [SGD]
  • PGK1, Chr III from 137740-138990 [yeast_orfs2]
  • Chr III from 137740-138990 [yeastorf3.fasta]
  • PGK1 SGDID:S0000605, Chr III from 137743-138993, Verified ORF [yeastflysequest.fasta]
  • 3-phosphoglycerate kinase [Saccharomyces cerevisiae]gi|14588927|emb|CAA42329.2| phosphoglycerate kinase [Saccharomyces cerevisiae]gi|1197055|gb|AAA88729.1| 3-phosphoglycerate kinasegi|129930|sp|P00560|PGK_YEAST Phosphoglycerate kinase [nrdb_11152004_Chlamydomonas]
  • PGK1 SGDID:S000000605, Chr III from 137743-138993, Verified ORF, "3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and glucone [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • PGK1 SGDID:S000000605, Chr III from 137744-138994, Verified ORF, "3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and glucone [yeast-contam.fasta]
  • phosphoglycerate kinase [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • 3-phosphoglycerate kinase [nr-271106-contam.fasta]
  • Phosphoglycerate kinase [nr-271106-contam.fasta]
  • 3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis; Pgk1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • PGK1 SGDID:S000000605, Chr III from 137744-138994, Verified ORF, "3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Phosphoglycerate kinase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PGK1 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • PGK1 SGDID:S000000605, Chr III from 137746-138996, Genome Release 64-1-1, Verified ORF, "3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis" [yeast-030211-contam.fasta]
  • PGK1 SGDID:S000000605, Chr III from 137746-138996, Genome Release 64-2-1, Verified ORF, "3-phosphoglycerate kinase; catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis" [20141208_orf_trans.fasta]
  • TR4464|c0_g1_i1|g.3157 ORF TR4464|c0_g1_i1|g.3157 TR4464|c0_g1_i1|m.3157 type:complete len:417 (+) TR4464|c0_g1_i1:59-1309(+) [Y12_S_cerevisiae-Sep2015-contam.fasta]
  • TR6919|c0_g1_i1|g.4949 ORF TR6919|c0_g1_i1|g.4949 TR6919|c0_g1_i1|m.4949 type:complete len:417 (+) TR6919|c0_g1_i1:45-1295(+) [DBVPG6044_S_cerevisiae-Sep2015-contam.fasta]
  • YCR012W SGDID:S000000605, Chr III from 137746-138996, Genome Release 64-1-1, Verified ORF, "3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
  • asmbl_9244|g.6635 ORF asmbl_9244|g.6635 asmbl_9244|m.6635 type:complete len:417 (+) asmbl_9244:74-1324(+) [Y12_Trinity_v2_2_0_PASA_6May2016-contam.fasta]
  • ID=asmbl_9234|g.5637 ORF ID=asmbl_9234|g.5637 ID=asmbl_9234|m.5637 type:complete len:417 (+) ID=asmbl_9234:83-1333(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
  • ID=asmbl_9252|g.5587 ORF ID=asmbl_9252|g.5587 ID=asmbl_9252|m.5587 type:complete len:417 (+) ID=asmbl_9252:74-1324(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 416 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    Biological Process: gluconeogenesis [IMPLink to PubMed article]
    glycolysis [IMPLink to PubMed article]
    Molecular Function: phosphoglycerate kinase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLSSKLSVQ DLDLKDKRVF IRVDFNVPLD GKKITSNQRI VAALPTIKYV LEHHPRYVVL  60
   61 ASHLGRPNGE RNEKYSLAPV AKELQSLLGK DVTFLNDCVG PEVEAAVKAS APGSVILLEN 120
  121 LRYHIEEEGS RKVDGQKVKA SKEDVQKFRH ELSSLADVYI NDAFGTAHRA HSSMVGFDLP 180
  181 QRAAGFLLEK ELKYFGKALE NPTRPFLAIL GGAKVADKIQ LIDNLLDKVD SIIIGGGMAF 240
  241 TFKKVLENTE IGDSIFDKAG AEIVPKLMEK AKAKGVEVVL PVDFIIADAF SADANTKTVT 300
  301 DKEGIPAGWQ GLDNGPESRK LFAATVAKAK TIVWNGPPGV FEFEKFAAGT KALLDEVVKS 360
  361 SAAGNTVIIG GGDTATVAKK YGVTDKISHV STGGGASLEL LEGKELPGVA FLSEKK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ENO2 FBA1 PGK1
    View Details Gavin AC, et al. (2006) CHS1 ENO2 PGK1
    View Details Gavin AC, et al. (2002) ADA2 ADH1 BLM10 CDC6 CMR1 COG3 COP1 CSE2 DNA2 ECM29 ENO2 FAB1 FBA1 GAL11 GCN5 GFA1 GLO3 GPT2 HDA1 HDA2 HDA3 HSC82 ILV1 KAP95 LCD1 MEC1 MED1 MED11 MED2 MED4 MED6 MED7 MED8 MGM101 MLH1 MLH2 MLP1 MPH1 MRPL6 MRPS28 MSH2 MSH3 MSH6 NAS6 NUT1 NUT2 OLA1 PGD1 PGK1 PMS1 PRE1 PRE10 PRE2 PRE3 PRE4 PRE5 PRE6 PRE7 PRE8 PRE9 PRO2 PUP3 RAD16 RAD23 RAD34 RAD4 RAD52 RET2 RET3 RFA1 RFA2 RFA3 RGR1 RIM1 RNH1 ROX3 RPG1 RPN10 RPN11 RPN12 RPN13 RPN3 RPN5 RPN6 RPN7 RPN8 RPN9 RPO21 RPT1 RPT2 RPT3 RPT4 RPT5 RPT6 RSC8 RVB2 SAM1 SCJ1 SCL1 SEC21 SEC26 SEC27 SEC28 SEH1 SGS1 SHS1 SIN4 SPF1 SPT7 SRB2 SRB4 SRB5 SRB6 SRB7 SRB8 SRO7 SRP1 SSE2 SSL1 SSN2 SSN3 SSN8 TAF6 TFA1 TFB1 TFB4 TIF1, TIF2 TOP3 TOS1 UBP6 VAS1 VPS1 YFL006W YHR122W YIL077C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run TOR1 No Comments Reinke A, et al. (2004)
    View Run TOR2 No Comments Reinke A, et al. (2004)
    View Run LST8 No Comments Reinke A, et al. (2004)
    View Run TOR2 No Comments Reinke A, et al. (2004)
    View Run CLB2 No Comments McCusker D, et al (2007)
    View Run BIR1 No Comments Widlund PO, et al. (2005)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run MIH1 experimental2 - mih1-2 McCusker D, et al (2007)
    View Run ASF1 3912: TAP-tagged, strain background includes hpc2(delta) Green EM, et al (2005)
    View Run RLF2 cac1: TAP-tagged Green EM, et al (2005)
    View Run VAM3 Sample: HX11 - both fusion and trans-SNARE complex formation take place. Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX14 - mixture in detergent (control). Hao Xu, et al. (2010)
    View Run MLP2 #19 Asynchronous Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #22 Asynchronous Prep2-IMAC Phosphopeptide enrichment B1-2 Keck JM, et al. (2011)
    View Run MLP2 #34 Asynchronous SPB prep Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #06 Alpha Factor Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #08 Alpha Factor Prep4-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #19b Asynchronous Prep1-new search criteria Keck JM, et al. (2011)
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #19a Asynchronous Prep1-new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PGK1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..190]
    [406..416]    		 PSI-BLAST 11000.0 Phosphoglycerate kinase
    2 View Details [191..405] PSI-BLAST 11000.0 Phosphoglycerate kinase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphoglycerate kinase activity
    		•  5.4060222740811 bayes_pls_golite062009
  • kinase activity
    		•  5.10875323814482 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.75644406547116 bayes_pls_golite062009
  • transferase activity
    		•  3.84971620558441 bayes_pls_golite062009
  • catalytic activity
    		•  2.30057758519011 bayes_pls_golite062009
  • phosphotransferase activity, carboxyl group as acceptor
    		•  2.28472985705972 bayes_pls_golite062009
  • binding
    		•  2.00400587462181 bayes_pls_golite062009
  • ATP binding
    		•  1.2270597395465 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.19223643201287 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.17740080861612 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.9898248694651 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.946046256290779 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.943434082819351 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.936146648259702 bayes_pls_golite062009
  • nucleotide binding
    		•  0.931721122227797 bayes_pls_golite062009
  • protein binding
    		•  0.206093694938779 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle