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Protein Overview: TBS1

General Information:
Name(s) found: TBS1 / YBR150C [SGD]
Description(s) found:
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  • gi|6319626|ref|NP_009708.1| Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Tbs1p [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S46021 probable regulatory protein YBR150c - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|586293|sp|P38114.1|TBS1_YEAST RecName: Full=Uncharacterized transcriptional regulatory protein TBS1; AltName: Full=Thiabendazole sensitive protein 1 [NCBI NR]
  • gi|536476|emb|CAA85108.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • Uncharacterized transcriptional regulatory protein YBR150C OS=Saccharomyces cerevisiae GN=YBR150C PE=1 SV=1 [Swiss-Prot]
  • Uncharacterized transcriptional regulatory protein TBS1 OS=Saccharomyces cerevisiae GN=TBS1 PE=1 SV=1 [Swiss-Prot]
  • TBS1 Zn-finger transcription factor protein [mips]
  • Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [SGD]
  • TBS1, Chr II from 541167-544451, reverse complement [yeast_orfs2]
  • Chr II from 541167-544451, reverse complement [yeastorf3.fasta]
  • Chr II from 541166-544450, reverse complement [yeastorf4.fasta]
  • Chr II from 544448-541164, reverse complement [yeastorf5.fasta]
  • (P38114) Putative 126.9 kDa transcriptional regulatory protein in YSW1-RIB7 intergenic region [4932.FASTACCERV.txt]
  • TBS1 SGDID:S0000354, Chr II from 544449-541165, reverse complement, Verified ORF [yeastflysequest.fasta]
  • TBS1 SGDID:S0000354, Chr II from 544487-541203, reverse complement, Verified ORF [10112005cervSGD.fasta]
  • Probable Zn-finger protein [Saccharomyces cerevisiae]gi|536476|emb|CAA85108.1| unnamed protein product [Saccharomyces cerevisiae]gi|626835|pir||S46021 probable regulatory protein YBR150c - yeast (Saccharomyces cerevisiae)gi|586293|sp|P38114|YB00_YEAST [nrdb_11152004_Chlamydomonas]
  • TBS1 SGDID:S000000354, Chr II from 544487-541203, reverse complement, Verified ORF, "Probable Zn-finger protein" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • TBS1 SGDID:S000000354, Chr II from 544487-541203, reverse complement, Verified ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • Probable transcriptional regulatory protein YBR150C [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Probable Zn-finger protein; Tbs1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Uncharacterized transcriptional regulatory protein TBS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TBS1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • TBS1 SGDID:S000000354, Chr II from 544493-541209, Genome Release 64-1-1, reverse complement, Verified ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" [yeast-030211-contam.fasta]
  • TBS1 SGDID:S000000354, Chr II from 544493-541209, Genome Release 64-2-1, reverse complement, Verified ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; TBS1 has a paralog, HAL9, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
  • YBR150C SGDID:S000000354, Chr II from 544493-541209, Genome Release 64-1-1, reverse complement, Verified ORF, "Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 1094 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    Biological Process: biological_process [ND]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNMDSGITSS HGSMDKTQKQ SSEWAANQKH NQRVENTRVL MGPAVPAMPP VPSNFPPVPT  60
   61 GTIMSPQLSP FPDHRLRHHP LAHMMPADKN FLAYNMESFK SRVTKACDYC RKRKIRCTEI 120
  121 EPISGKCRNC IKYNKDCTFH FHEELKRRRE EALNNKGNGK SVKKPRLDKE NKFKDENFDI 180
  181 AVRSRNTSST DSSPKLHTNL SQEYIGVSAG KSASDKEDTW PDFVPIDRTV LEKIELNHTK 240
  241 VAGKVFVLEE ICKNMKGTIE KLAEKSKIDV IDKEYMKRPK RKQYSKALLT KQKMFHFRQN 300
  301 VLSHLTDEEF LSPINEMFTT TFKYSILQTK LVLDFSFRSA SSPSSDNILY PLPRLAIAKR 360
  361 LLKNIKCPSL ASLLHIVDVD QCLQFADVHF DPAKGRLTSS QAFLLNICLC LGATVTNFEE 420
  421 KQELVDEDNH ETYYFEKFEL WRLRSFTFLN SVYYYHKLSV ARADMTALKA LLLLAKFAQQ 480
  481 KISASSAVKV LSVAIKVALD LRLNLHSTYE DLELDEIIKR RRLWCYCFST DKFFSVVLSR 540
  541 PPFLKEENTD VLTDESYVEL FRDKILPNLS IKYDDSKLEG VKDIVSVVNL LANHLEYVPY 600
  601 IQSYFLSRLS LIESQIYYSC FSIRTTLDDT LDEIIENVLE NQKALDRMRD DLPTILSLEN 660
  661 YKENMRILSL DSSKLDFEVS CCTTILLHLR WYHQKITLSL FVISIIGDNL DQRESSRHDI 720
  721 AEIIRRSRLD FKRNCIEVLN ILKDFEYYPT VQNEFLYFSL TTVFSMFLYL SEIMVNDEHA 780
  781 METGYIIGLL RDTHTRMLGS EERCLSVHNL KWQTSLFFYT FFLRSTMEKF NLTSKYAKFY 840
  841 AFDSNYYEGV LNRLVKHTRE SKDDMVELLK TSFINKEKMA AFGSFVTEDQ EKMEVSFNIF 900
  901 NEITIQDLNF LQFSSIPKLW ENKTLEPGEE YHHSNGTNTD NNETTGADDT DDNNNNNNNN 960
  961 NKNGNNSSST INNNNNNYSN SNNNDNDNNI NDDDDDDDDD DDDDDDDDDD DDNDDDYSNN1020
 1021 GADDDEEDDD YDRSLFPTGL ASLLDASYPE RTANDYRDEN EQSNKLFEKI EGHLEHGVFF1080
 1081 YDRDFFFKNV CVKM

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) MDN1 TBS1
    View Details Ho Y, et al. (2002) ACC1 ACH1 ADH2 ADR1 GCD11 GFA1 GND1 GUS1 IDH2 ISA2 MDH1 MET18 NGL2 PYC1 PYC2 RET1 RPA135 RPA190 RPA49 RPB5 RPC19 RPC25 RPC34 RPC40 RPC82 RPN3 RPO26 RPO31 RVS167 SEC27 TBS1 TFP1 TSA2 YFL042C YHR112C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data TBS1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..57] deduced N/A Confident ab initio structure predictions are available.
    2 View Details [58..178] PSI-BLAST 44.512579 CD2-Lac9
    3 View Details [179..338] deduced N/A No confident structure predictions are available.
    4 View Details [339..624] MSA 5.096995 View MSA. No confident structure predictions are available.
    5 View Details [625..915] deduced N/A No confident structure predictions are available.
    6 View Details [916..975] ORFEUS 7.16 No description for 1l8mA was found.
    7 View Details [976..1094] ORFEUS 7.16 No description for 1l8mA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • nucleic acid binding
    		•  2.55832554210202 bayes_pls_golite062009
  • DNA binding
    		•  2.48009340951204 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.39344671016496 bayes_pls_golite062009
  • binding
    		•  2.32645838605286 bayes_pls_golite062009
  • transcription factor activity
    		•  1.25308658158845 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.75311920044374 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.68524247899289 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.53107237892739 bayes_pls_golite062009
    3
    Term Confidence Notes
  • nucleic acid binding
    		•  2.36440811505803 bayes_pls_golite062009
  • DNA binding
    		•  2.25848660128916 bayes_pls_golite062009
  • binding
    		•  2.23525969523197 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.17762225700059 bayes_pls_golite062009
  • transcription factor activity
    		•  1.07713564675134 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.523017357555093 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.479128525355337 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.176810808981692 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle