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Protein Overview: TRM7

General Information:
Name(s) found: TRM7 / YBR061C [SGD]
Description(s) found:
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  • gi|6319535|ref|NP_009617.1| 2'-O-ribose methyltransferase, methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop; Trm7p [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S45919 hypothetical protein YCL054W homolog YBR061c - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|586500|sp|P38238.1|TRM7_YEAST RecName: Full=tRNA (uridine-2'-O-)-methyltransferase TRM7 [NCBI NR]
  • gi|536303|emb|CAA85004.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • (P38238) Putative ribosomal RNA methyltransferase YBR061c (EC 2.1.1.-) (rRNA (uridine-2'-O-)-methyltransferase) [Swiss-Prot]
  • tRNA (uridine-2'-O-)-methyltransferase TRM7 OS=Saccharomyces cerevisiae GN=TRM7 PE=1 SV=1 [Swiss-Prot]
  • TRM7 2-O-ribose tRNA anticodon loop methyltransferase [mips]
  • 2'-O-ribose methyltransferase, methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop [SGD]
  • YBR061C, Chr II from 364746-365678, reverse complement [yeast_orfs2]
  • Chr II from 364746-365678, reverse complement [yeastorf3.fasta]
  • Chr II from 365678-364746, reverse complement [yeastorf5.fasta]
  • TRM7 SGDID:S0000265, Chr II from 365679-364747, reverse complement, Verified ORF [yeastflysequest.fasta]
  • TRM7 SGDID:S0000265, Chr II from 365717-364785, reverse complement, Verified ORF [10112005cervSGD.fasta]
  • 2'-O-ribose methyltransferase, methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop [Saccharomyces cerevisiae]gi|536303|emb|CAA85004.1| unnamed protein product [Saccharomyces cerevisiae]gi|626560|pir||S45919 hypoth [nrdb_11152004_Chlamydomonas]
  • TRM7 SGDID:S000000265, Chr II from 365717-364785, reverse complement, Verified ORF, "2'-O-ribose methyltransferase, methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • 2'-O-ribose methyltransferase, methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop; Trm7p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • tRNA (uridine-2'-O-)-methyltransferase TRM7 [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TRM7 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • TRM7 SGDID:S000000265, Chr II from 365719-364787, Genome Release 64-1-1, reverse complement, Verified ORF, "2'-O-ribose methyltransferase, methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop" [yeast-030211-contam.fasta]
  • TRM7 SGDID:S000000265, Chr II from 365719-364787, Genome Release 64-2-1, reverse complement, Verified ORF, "2'-O-ribose methyltransferase; methylates the 2'-O-ribose of tRNA-Phe, tRNA-Trp, and tRNA-Leu at positions C32 and N34 of the tRNA anticodon loop; crucial biological role likely modification of tRNA-Phe; interacts with Trm732p and Rtt10p in 2'-O-methylation of C32 and N34 substrate tRNAs, respectively" [20141208_orf_trans.fasta]
  • TR8658|c0_g1_i1|g.6004 ORF TR8658|c0_g1_i1|g.6004 TR8658|c0_g1_i1|m.6004 type:complete len:311 (+) TR8658|c0_g1_i1:72-1004(+) [Y12_S_cerevisiae-Sep2015-contam.fasta]
  • YBR061C SGDID:S000000265, Chr II from 365719-364787, Genome Release 64-1-1, reverse complement, Verified ORF, "2'-O-ribose methyltransferase, methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
  • ID=asmbl_5012|g.2919 ORF ID=asmbl_5012|g.2919 ID=asmbl_5012|m.2919 type:complete len:311 (+) ID=asmbl_5012:71-1003(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 310 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: tRNA methylation [IDALink to PubMed article]
    translation [IMPLink to PubMed article]
    Molecular Function: tRNA methyltransferase activity [IDALink to PubMed article][IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGKSSKDKRD LYYRKAKEQG YRARSAFKLL QLNDQFHFLD DPNLKRVVDL CAAPGSWSQV  60
   61 LSRKLFDESP SSDKEDRKIV SVDLQPMSPI PHVTTLQADI THPKTLARIL KLFGNEKADF 120
  121 VCSDGAPDVT GLHDLDEYVQ QQLIMSALQL TACILKKGGT FVAKIFRGRD IDMLYSQLGY 180
  181 LFDKIVCAKP RSSRGTSLEA FIVCLGYNPP SNWTPKLDVN TSVDEFFQGC FLNKLCISDK 240
  241 LSHWNEEERN IAEFMACGSL QSFDSDATYH DLPSSVAGTS SSLDPVQSPT NPPYKKALEL 300
  301 KRSGKLTRSV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CLB1 CUE5 LSB3 RTT10 TRM7 YMR259C YSC84

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RLF2 cac1: TAP-tagged Green EM, et al (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data TRM7 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..213] PSI-BLAST 270.0 RNA methyltransferase FtsJ
    2 View Details [214..310] MSA 2.138992 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • methyltransferase activity
    		•  4.15445027778357 bayes_pls_golite062009
  • rRNA methyltransferase activity
    		•  4.09362182773099 bayes_pls_golite062009
  • N-methyltransferase activity
    		•  4.07806017452628 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  4.07153733729662 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  3.92746815303714 bayes_pls_golite062009
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  3.39429041855776 bayes_pls_golite062009
  • RNA methyltransferase activity
    		•  3.07428840534971 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  2.99461585647365 bayes_pls_golite062009
  • transferase activity
    		•  2.926540904444 bayes_pls_golite062009
  • tRNA methyltransferase activity
    		•  2.5931020126592 bayes_pls_golite062009
  • protein-arginine N-methyltransferase activity
    		•  2.41876112831625 bayes_pls_golite062009
  • arginine N-methyltransferase activity
    		•  2.41876112831625 bayes_pls_golite062009
  • DNA-methyltransferase activity
    		•  2.18991764495147 bayes_pls_golite062009
  • histone-arginine N-methyltransferase activity
    		•  2.04296107639729 bayes_pls_golite062009
  • tRNA (cytosine)-methyltransferase activity
    		•  1.88889414729709 bayes_pls_golite062009
  • tRNA (cytosine-5-)-methyltransferase activity
    		•  1.88889414729709 bayes_pls_golite062009
  • rRNA (adenine) methyltransferase activity
    		•  1.83964463328968 bayes_pls_golite062009
  • rRNA (adenine-N6,N6-)-dimethyltransferase activity
    		•  1.75675289134467 bayes_pls_golite062009
  • protein-arginine omega-N monomethyltransferase activity
    		•  1.66871163498737 bayes_pls_golite062009
  • tRNA (adenine-N1-)-methyltransferase activity
    		•  1.29759910099835 bayes_pls_golite062009
  • tRNA (adenine)-methyltransferase activity
    		•  1.29759910099835 bayes_pls_golite062009
  • catalytic activity
    		•  1.25333584501255 bayes_pls_golite062009
  • histone methyltransferase activity (H4-R3 specific)
    		•  1.1103522853299 bayes_pls_golite062009
  • rRNA (guanine) methyltransferase activity
    		•  1.10713374933008 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.914549843668268 bayes_pls_golite062009
  • protein-arginine omega-N asymmetric methyltransferase activity
    		•  0.89325812193225 bayes_pls_golite062009
  • DNA binding
    		•  0.71058003448013 bayes_pls_golite062009
  • site-specific DNA-methyltransferase (adenine-specific) activity
    		•  0.703178429468566 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.698509190696763 bayes_pls_golite062009
  • RNA binding
    		•  0.417524996559564 bayes_pls_golite062009
  • binding
    		•  0.383237930789959 bayes_pls_golite062009
  • protein-arginine omega-N symmetric methyltransferase activity
    		•  0.364369105571521 bayes_pls_golite062009
  • O-methyltransferase activity
    		•  0.250946859465502 bayes_pls_golite062009
  • rRNA (guanine-N1-)-methyltransferase activity
    		•  0.234572322347698 bayes_pls_golite062009
  • tRNA (guanine) methyltransferase activity
    		•  0.203168546434167 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle