Protein Overview: CDC19

General Information:
Name(s) found:	CDC19 / YAL038W [SGD]
Description(s) found: SHOW ONLY BEST	pir\|\|KIBYP pyruvate kinase (EC 2.7.1.40) - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|6319279\|ref\|NP_009362.1\| Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration; Cdc19p [Saccharomyces cerevisiae] [NCBI NR] gi\|63028851\|gb\|AAY27292.1\| CDC19 [Saccharomyces cerevisiae] [NCBI NR] gi\|63028849\|gb\|AAY27291.1\| CDC19 [Saccharomyces cerevisiae] [NCBI NR] gi\|63028847\|gb\|AAY27290.1\| CDC19 [Saccharomyces cerevisiae] [NCBI NR] gi\|63028845\|gb\|AAY27289.1\| CDC19 [Saccharomyces cerevisiae] [NCBI NR] gi\|63028843\|gb\|AAY27288.1\| CDC19 [Saccharomyces cerevisiae] [NCBI NR] gi\|63028841\|gb\|AAY27287.1\| CDC19 [Saccharomyces cerevisiae] [NCBI NR] gi\|63028839\|gb\|AAY27286.1\| CDC19 [Saccharomyces cerevisiae] [NCBI NR] gi\|63028837\|gb\|AAY27285.1\| CDC19 [Saccharomyces cerevisiae] [NCBI NR] gi\|63028835\|gb\|AAY27284.1\| CDC19 [Saccharomyces cerevisiae] [NCBI NR] gi\|63028833\|gb\|AAY27283.1\| CDC19 [Saccharomyces cerevisiae] [NCBI NR] gi\|63028831\|gb\|AAY27282.1\| CDC19 [Saccharomyces cerevisiae] [NCBI NR] gi\|63028829\|gb\|AAY27281.1\| CDC19 [Saccharomyces cerevisiae] [NCBI NR] gi\|63028827\|gb\|AAY27280.1\| CDC19 [Saccharomyces cerevisiae] [NCBI NR] gi\|63028825\|gb\|AAY27279.1\| CDC19 [Saccharomyces cerevisiae] [NCBI NR] gi\|63028823\|gb\|AAY27278.1\| CDC19 [Saccharomyces cerevisiae] [NCBI NR] gi\|63028821\|gb\|AAY27277.1\| CDC19 [Saccharomyces cerevisiae] [NCBI NR] gi\|63028819\|gb\|AAY27276.1\| CDC19 [Saccharomyces cerevisiae] [NCBI NR] gi\|63028817\|gb\|AAY27275.1\| CDC19 [Saccharomyces cerevisiae] [NCBI NR] gi\|63028815\|gb\|AAY27274.1\| CDC19 [Saccharomyces cerevisiae] [NCBI NR] gi\|63028813\|gb\|AAY27273.1\| CDC19 [Saccharomyces cerevisiae] [NCBI NR] gi\|63028811\|gb\|AAY27272.1\| CDC19 [Saccharomyces cerevisiae] [NCBI NR] gi\|63028809\|gb\|AAY27271.1\| CDC19 [Saccharomyces cerevisiae] [NCBI NR] gi\|63028807\|gb\|AAY27270.1\| CDC19 [Saccharomyces cerevisiae] [NCBI NR] gi\|63028805\|gb\|AAY27269.1\| CDC19 [Saccharomyces cerevisiae] [NCBI NR] gi\|63028803\|gb\|AAY27268.1\| CDC19 [Saccharomyces cerevisiae] [NCBI NR] gi\|63028801\|gb\|AAY27267.1\| CDC19 [Saccharomyces cerevisiae] [NCBI NR] gi\|63028799\|gb\|AAY27266.1\| CDC19 [Saccharomyces cerevisiae] [NCBI NR] gi\|63028797\|gb\|AAY27265.1\| CDC19 [Saccharomyces cerevisiae] [NCBI NR] gi\|63028795\|gb\|AAY27264.1\| CDC19 [Saccharomyces cerevisiae] [NCBI NR] gi\|595546\|gb\|AAC04993.1\| Cdc19p: pyruvate kinase [Saccharomyces cerevisiae] [NCBI NR] gi\|5265\|emb\|CAA32573.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] gi\|51013665\|gb\|AAT93126.1\| YAL038W [Saccharomyces cerevisiae] [NCBI NR] gi\|3212331\|pdb\|1A3X\|B Chain B, Pyruvate Kinase From Saccharomyces Cerevisiae Complexed With Pg, Mn2+ And K+ [NCBI NR] gi\|3212330\|pdb\|1A3X\|A Chain A, Pyruvate Kinase From Saccharomyces Cerevisiae Complexed With Pg, Mn2+ And K+ [NCBI NR] gi\|3212329\|pdb\|1A3W\|B Chain B, Pyruvate Kinase From Saccharomyces Cerevisiae Complexed With Fbp, Pg, Mn2+ And K+ [NCBI NR] gi\|3212328\|pdb\|1A3W\|A Chain A, Pyruvate Kinase From Saccharomyces Cerevisiae Complexed With Fbp, Pg, Mn2+ And K+ [NCBI NR] gi\|125609\|sp\|P00549.2\|KPYK1_YEAST RecName: Full=Pyruvate kinase 1; Short=PK 1 [NCBI NR] Pyruvate kinase 1 OS=Saccharomyces cerevisiae GN=PYK1 PE=1 SV=2 [Swiss-Prot] (P00549) Pyruvate kinase 1 (EC 2.7.1.40) (PK 1) [Swiss-Prot] CDC19 Pyruvate kinase [mips] Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration [SGD] CDC19, Chr I from 71788-73290 [yeast_orfs2] Chr I from 71788-73290 [yeastorf3.fasta] CDC19 SGDID:S0000036, Chr I from 71789-73291, Verified ORF [yeastflysequest.fasta] CDC19 SGDID:S0000036, Chr I from 71787-73289, Verified ORF [10112005cervSGD.fasta] Cdc19p [Saccharomyces cerevisiae]gi\|51013665\|gb\|AAT93126.1\| YAL038W [Saccharomyces cerevisiae]gi\|5265\|emb\|CAA32573.1\| unnamed protein product [Saccharomyces cerevisiae]gi\|66859\|pir\|\|KIBYP pyruvate kinase (EC 2.7.1.40) - yeast (Saccharomyces cerevisiae) [nrdb_11152004_Chlamydomonas] CDC19 SGDID:S000000036, Chr I from 71787-73289, Verified ORF, "Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] CDC19 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] YAL038W [Saccharomyces cerevisiae] [nr-271106-contam.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration; Cdc19p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Chain A, Pyruvate Kinase From Saccharomyces Cerevisiae Complexed With Fbp, Pg, Mn2+ And K+ [nr-271106-contam.fasta] Chain A, Pyruvate Kinase From Saccharomyces Cerevisiae Complexed With Pg, Mn2+ And K+ [nr-271106-contam.fasta] Cdc19p: pyruvate kinase [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Chain B, Pyruvate Kinase From Saccharomyces Cerevisiae Complexed With Pg, Mn2+ And K+ [nr-271106-contam.fasta] Chain B, Pyruvate Kinase From Saccharomyces Cerevisiae Complexed With Fbp, Pg, Mn2+ And K+ [nr-271106-contam.fasta] Pyruvate kinase 1 (PK 1) [nr-271106-contam.fasta] [chemostatdb.fasta] Pyruvate kinase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CDC19 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] CDC19 SGDID:S000000036, Chr I from 71786-73288, Genome Release 64-1-1, Verified ORF, "Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration" [yeast-030211-contam.fasta] CDC19 SGDID:S000000036, Chr I from 71786-73288, Genome Release 64-2-1, Verified ORF, "Pyruvate kinase; functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration; regulated via allosteric activation by fructose bisphosphate; CDC19 has a paralog, PYK2, that arose from the whole genome duplication" [20141208_orf_trans.fasta] TR8137\|c0_g1_i1\|g.5632 ORF TR8137\|c0_g1_i1\|g.5632 TR8137\|c0_g1_i1\|m.5632 type:complete len:501 (+) TR8137\|c0_g1_i1:36-1538(+) [Y12_S_cerevisiae-Sep2015-contam.fasta] TR8686\|c0_g1_i1\|g.6149 ORF TR8686\|c0_g1_i1\|g.6149 TR8686\|c0_g1_i1\|m.6149 type:complete len:501 (+) TR8686\|c0_g1_i1:141-1643(+) [DBVPG6044_S_cerevisiae-Sep2015-contam.fasta] YAL038W SGDID:S000000036, Chr I from 71786-73288, Genome Release 64-1-1, Verified ORF, "Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] asmbl_9625\|g.6955 ORF asmbl_9625\|g.6955 asmbl_9625\|m.6955 type:complete len:501 (+) asmbl_9625:138-1640(+) [DBVPG6044_Trinity_v2_2_0_PASA_6May2016-contam.fasta] asmbl_9577\|g.6916 ORF asmbl_9577\|g.6916 asmbl_9577\|m.6916 type:complete len:501 (+) asmbl_9577:87-1589(+) [Y12_Trinity_v2_2_0_PASA_6May2016-contam.fasta] ID=asmbl_9599\|g.5889 ORF ID=asmbl_9599\|g.5889 ID=asmbl_9599\|m.5889 type:complete len:501 (+) ID=asmbl_9599:138-1640(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta] ID=asmbl_9583\|g.5803 ORF ID=asmbl_9583\|g.5803 ID=asmbl_9583\|m.5803 type:complete len:501 (+) ID=asmbl_9583:87-1589(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	500 amino acids
Gene Ontology:
Cellular Component:	cytosol [TAS]
Biological Process:	glycolysis [IMP] pyruvate metabolic process [IMP]
Molecular Function:	pyruvate kinase activity [IDA][IMP]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRLERLTSL NVVAGSDLRR TSIIGTIGPK TNNPETLVAL RKAGLNIVRM NFSHGSYEYH  60
   61 KSVIDNARKS EELYPGRPLA IALDTKGPEI RTGTTTNDVD YPIPPNHEMI FTTDDKYAKA 120
  121 CDDKIMYVDY KNITKVISAG RIIYVDDGVL SFQVLEVVDD KTLKVKALNA GKICSHKGVN 180
  181 LPGTDVDLPA LSEKDKEDLR FGVKNGVHMV FASFIRTAND VLTIREVLGE QGKDVKIIVK 240
  241 IENQQGVNNF DEILKVTDGV MVARGDLGIE IPAPEVLAVQ KKLIAKSNLA GKPVICATQM 300
  301 LESMTYNPRP TRAEVSDVGN AILDGADCVM LSGETAKGNY PINAVTTMAE TAVIAEQAIA 360
  361 YLPNYDDMRN CTPKPTSTTE TVAASAVAAV FEQKAKAIIV LSTSGTTPRL VSKYRPNCPI 420
  421 ILVTRCPRAA RFSHLYRGVF PFVFEKEPVS DWTDDVEARI NFGIEKAKEF GILKKGDTYV 480
  481 SIQGFKAGAG HSNTLQVSTV

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	(MIPS) Mewes HW, et al. (2004)		CDC19 PYK2

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	TOR1	No Comments	Reinke A, et al. (2004)
View Run	TOR2	No Comments	Reinke A, et al. (2004)
View Run	LST8	No Comments	Reinke A, et al. (2004)
View Run	TOR2	No Comments	Reinke A, et al. (2004)
View Run	KOG1	No Comments	Reinke A, et al. (2004)
View Run	CLB2	No Comments	McCusker D, et al (2007)
View Run	CLB2	No Comments	McCusker D, et al (2007)
View Run	SEC10	No Comments	De Craene, J., et al. (2006)
View Run	BIR1	No Comments	Widlund PO, et al. (2005)
View Run	DAD1	Dam1 complex purified from yeast with Dad1-TAP	Shimogawa MM, et al. (2006)
View Run	RPA135	his-HA tag on RPA135	Schneider, DA, et al. (2006)
View Run	RPA135	his-HA tag on RPA135	Schneider, DA, et al. (2006)
View Run	RPA135	his-HA tag on RPA135	Schneider, DA, et al. (2006)
View Run	RPA135	his-HA tag on RPA135	Schneider, DA, et al. (2006)
View Run	HIR2	No Comments	Green EM, et al (2005)
View Run	DAD1	Dam1-765 complex purified from yeast with Dad1-TAP	Shimogawa MM, et al. (2006)
View Run	ASF1	3912: TAP-tagged, strain background includes hpc2(delta)	Green EM, et al (2005)
View Run	RLF2	cac1: TAP-tagged	Green EM, et al (2005)
View Run	DAD1	Dam1-765 complex purified from yeast with Dad1-TAP	Shimogawa MM, et al. (2006)
View Run	DAD1	Dam1 complex purified from yeast with Dad1-TAP	Shimogawa MM, et al. (2006)
View Run	RLF2	phosphorylation data - cascade search	Green EM, et al (2005)
View Run	RLF2	identification data - first search in cascade	Green EM, et al (2005)
View Run	ZDS1	Sample 2- cpn2 from june 2005	McCusker D, et al (2007)
View Run	ZDS1	Sample 3 - cpn + atp, from june 2005	McCusker D, et al (2007)
View Run	BOI1	Sample boi 1 with ha tag from october 2005	McCusker D, et al (2007)
View Run	BOI1	Sample boi1 with gst from october 2005	McCusker D, et al (2007)
View Run	BOI2	Boi 2 gst control	McCusker D, et al (2007)
View Run	VAM3	sample: hx1	Hao Xu, et al. (2010)
View Run	VAM3	sample: hx2	Hao Xu, et al. (2010)
View Run	VAM3	sample: hx3	Hao Xu, et al. (2010)
View Run	VAM3	sample: hx4	Hao Xu, et al. (2010)
View Run	VAM3	Sample: HX11 - both fusion and trans-SNARE complex formation take place.	Hao Xu, et al. (2010)
View Run	VAM3	Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control).	Hao Xu, et al. (2010)
View Run	VAM3	Sample: HX13 - trans-SNARE complex forms but fusion is blocked.	Hao Xu, et al. (2010)
View Run	VAM3	Sample: HX14 - mixture in detergent (control).	Hao Xu, et al. (2010)
View Run	VAM3	hx21: both fusion and trans-SNARE complex formation take place. Investigating Vam3p, Nyv1p and their partners in trans-SNARE complex	Hao Xu, et al. (2010)
View Run	VAM3	hx23: mixture in detergent (control) Investigating Vam3p, Nyv1p and their partners in trans-SNARE complex	Hao Xu, et al. (2010)
View Run	MLP2	#19 Asynchronous Prep1-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#20 Asynchronous Prep1-TiO2 Phosphopeptide enrichment, PartB	Keck JM, et al. (2011)
View Run	MLP2	#25 Asynchronous Prep3-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2	Keck JM, et al. (2011)
View Run	MLP2	#22 Asynchronous Prep2-IMAC Phosphopeptide enrichment B1-2	Keck JM, et al. (2011)
View Run	MLP2	#34 Asynchronous SPB prep	Keck JM, et al. (2011)
View Run	MLP2	#32 Asynchronous Prep-No Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#31 Asynchronous Prep (Protease cleavage)	Keck JM, et al. (2011)
View Run	MLP2	#04 Alpha Factor Prep2	Keck JM, et al. (2011)
View Run	MLP2	#03 Alpha Factor Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#14 Mitotic Prep2-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#13 Mitotic Prep2-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#12 Mitotic Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#10 Mitotic Prep1-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#02 Alpha Factor Prep1-TiO2 enriched, new search criteria	Keck JM, et al. (2011)
View Run	MLP2	#30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#11 Mitotic Prep1-TiO2 enriched, new search criteria	Keck JM, et al. (2011)
View Run	MLP2	#06 Alpha Factor Prep3-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#08 Alpha Factor Prep4-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#19b Asynchronous Prep1-new search criteria	Keck JM, et al. (2011)
View Run	None Entered	#17 Mitotic Prep3-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#19a Asynchronous Prep1-new search criteria	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	CDC19	Huh WK, et al. (2003)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..89] [186..360]	PSI-BLAST	10180.0	Pyruvate kinase (PK); Pyruvate kinase, N-terminal domain; Pyruvate kinase, C-terminal domain
2	View Details	[90..185] [361..500]	PSI-BLAST	10180.0	Pyruvate kinase (PK); Pyruvate kinase, N-terminal domain; Pyruvate kinase, C-terminal domain

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.97

Protein Overview: CDC19

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: